Tag: "systemic" at biology news

Enzyme delivered in smaller package protects cells from radiation damage

...d in preparation for a potential clinical trial of systemic MnSOD in humans, the University of Pittsburgh and ...d give patients receiving total body radiation for systemic cancers better long-term outcomes. This also has implications for the prophylactic protection of tho...

Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model

...cant recovery of intracavernous pressure (ICP) and systemic arterial pressure (AP) compared with rats treated with the control virus or untreated mice with ED. Rats treated with HSV-neurturin also exhibited significant recovery of ICP and AP compared with the control or untreated mice at four weeks after trea...

Studies to find better ways to preserve human eggs, ovarian tissue under way

...other cancers often leaves women infertile because systemic chemotherapy and more focused radiation therapy, designed to kill rapidly spreading cancer cells, also can destroy dynamic reproductive tissue. “I don’t think when you are faced with the reality that you may die, your fertility is the most import...

Human stem cell treatment restores motor function in paralyzed rats

...t for debilitating muscle spasticity is continuous systemic or spinal drug treatments using implanted pumps. These approaches, while effective to a degree, are often accompanied by side effects and eventual drug tolerance that lessens their efficacy. “These research findings could offer great hope to peop...

Keeping the immune system from starting a 'food fight'

...ays and inhibition of insulin action, resulting in systemic metabolic deterioration over the long term," he continued....

Dealing deadly cancers a knockout punch

...r, Phase II study follows successful completion of systemic administration trials with Reolysin in the U.K. and the U.S. This will be the second of several Phase II trials Oncolytics plans for 2007. The Company also has a collaborative agreement with the U.S. National Cancer Institute to conduct multiple cl...

Researchers design pulsed mircrojet system to deliver protein drugs without pain or bruising

...be used to effectively deliver drugs for local and systemic applications without using needles. "The microjet system delivers precise doses into superficial skin layers, thereby mitigating pain," says Samir Mitragotri, a professor of chemical engineering at UCSB and a lead author of the paper. The system ...

UTSA researchers examine effects of global warming on Antarctic

...we're only seeing these regional changes and not a systemic decline in the amount of ice cover, it is still significant in terms of the way the regions are responding and we're finding that it's linked to global change in the atmosphere." The Antarctic trip, the first for both Xie and Cicek is not the las...

Antifungal drug kills TB bug

...ready target P450s as a way to treat, for example, systemic and more superficial infections caused by fungi such as Candida albicans (the causative agent of thrush). "The class of drugs called azoles are able to kill off fungal infections by blocking the actions of one of its P450s that is essential for ma...

Twin studies reveal genetic components leading to cardiac and kidney disease

...as identified three genes that are correlated with systemic inflammation. This study indicates a strong effect of heredity in the occurrence of C-reactive protein or CRP, a blood protein that serves as a marker for inflammation. Its presence indicates a heightened state of inflammation in the body and can in...

Cancer researchers add spice to research against rare neuromuscular disease

...r," said Chang. "But this can cause many unwanted, systemic side effects. We take another approach: Instead of taking away the substances that turn on the receptor, we look for ways to attack the faulty receptor directly. In this experiment, for instance, the mice treated with ASC-J9 have normal fertility and...

A revolution in the monitoring of unborn babies

...tions like diabetes, autoimmune conditions such as systemic lupus erythematosus and Sjogren’s syndrome and obstetric cholestasis. It will also be useful in monitoring fetuses identified as growing poorly or where it is suspected that the placenta is unhealthy and hence the fetus may become compromised due to ...

Protein may hold key to decreasing organ dysfunction rates in heart transplants

...ggesting the protein's possible involvement in the systemic response to IR. "The major goal of our research activities is therefore to understand the exact mechanisms of this injury concomitant to organ transplantation," notes Aigner, stressing the value of this research to the development of new treatment op...

Minuscule molecules pack a powerful punch

...issue, with scarring that is similar to some human systemic autoimmune disorders. To uncover how miR-155 might cause such widespread disruption of the immune system, the team used genomic studies to identify protein genes whose activity was controlled by miR-155 in T-cells. Activity of more than 150 genes,...

St. Jude announces breakthrough in eye cancer treatment

...ment of a drug at the site of disease, rather than systemic treatment. In systemic treatment, such as chemotherapy, a drug is infused into the body through a vein and then circulates,...

OHSU researchers demonstrate how white blood cells cannibalize virus-infected cells

...ew research shows this can happen in response to a systemic viral infection. "If you use a fluorescent dye to stain infected cells, you can literally watch T-cells consume membranes and outer surfaces of diseased cells. As they destroy and cannibalize the fluorescently labeled cells, they become labeled wit...

Gene chip technology shows potential for identifying life-threatening blood infection

...on. Early symptoms of sepsis and non-infectious systemic inflammation are subtle and similar - fever and an...Currently, a diagnosis of sepsis or non-infectious systemic inflammation is made by sending cultures of patients' blood, sputum, or urine to the laboratory for ...

Gene therapy study takes aim at prostate cancer

...ints in the body. "We hope that by generating a systemic immune response, we are enabling the body to destroy prostate cancer cells that have moved elsewhere," he said. Kadmon and his colleagues plan to test six different doses of the gene. The gene therapy involves attaching an inactivated adenovirus (r...

A new jump start for aging blood vessels

...as TNFa released into the blood, where it can have systemic effects, but it is also expressed within blood vessel walls, where it can exert specific local effects. Lastly, administration of TNFa to young arteries reproduced the features of vascular aging, such as blood vessel dysfunction and cell death, fu...

Blood-compatible nanoscale materials possible using heparin

... dialyzer could potentially eliminate the need for systemic administration of heparin to the patient during kidney dialysis, the researchers say. The heparin-coated membranes are described in a paper titled "Ionic Liquid-Derived Blood Compatible Membranes for Kidney Dialysis," published online Apr. 24 in ad...

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