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Tag: "susceptibility" at biology news

Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

...t deficient DNA repair capacity is associated with susceptibility to breast cancer and may be a valuable in vitro biomarker to identify high-risk subjects, especially in familial breast cancer families," the authors write. "It is unclear at this time whether there are any interventions that could alter DNA repair c...

Source of molecular triggers in cutaneous T cell lymphoma identified

... T cells to microbial agents. This may explain the susceptibility of patients with extensive CTCL to opportunistic infections. "Through understanding T cell and dendritic cell interactions, we may gain the ability to manage a spectrum of maladies ranging from cancer to disorders of immune regulation," said Edelson...

Topical treatment shown to inhibit HIV and herpes simplex virus infection

... inflammatory responses could potentially increase susceptibility to HIV and limit any protective effect of microbicides." said Betsy Herold, M.D., Professor of Medicine and Chief of Pediatric Infectious Disease at Mount Sinai and the senior investigator on this study. "We are currently conducting a 14-day study to...

Female sex hormones play a vital role in defense against sexually transmitted diseases

..., show that sex hormones have a profound effect on susceptibility of female mice to the herpes simplex virus, type 2...emale mice, sex hormones have a profound effect on susceptibility to sexually transmitted infections as well as on the body's defense mechanisms against them." One o...

Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance

...ting diseases, to being able to predicting disease susceptibility and an individual's response to drugs," said Patrick Kelly, European Site Manager and Vice President, Affymetrix. "This is what personalized medicine is all about -- enabling clinicians to detect diseases earlier and manage them more effectively. We ...

Rats infected as newborns grew up vulnerable to memory problems during an immune challenge

...al stressors before or just after birth may foster susceptibility to neuropsychiatric and neurodegenerative diseases. For example, prenatal viral infection has been implicated in schizophrenia, autism and cerebral palsy; bacterial infection is a risk factor for Parkinson's disease. Up to 20 percent of pregnancies h...

Increased risk of osteoporosis associated with gene that one in five people have

... people have a genetic variation that may increase susceptibility to osteoporosis, a new study reveals. Researchers at Washington University School of Medicine in St. Louis demonstrated that in women the variant gene speeds up the breakdown of estrogen and is associated with low density in the bones of the hip. Th...

Reservoirs may accelerate the spread of invasive aquatic species, researchers say

...ggests that these characteristics will enhance the susceptibility of reservoirs to invasion. Because reservoirs are more saline that freshwater lakes, Havel, Lee, and Vander Zanden propose they could provide a haven that helps invaders from saline and brackish habitats adapt to fresh water. Several invasive specie...

Harmful chemicals may reprogram gene response to estrogen

...the uterus can interact with a preexisting genetic susceptibility to increase the risk of disease," said Walker. "We are looking at a new kind of gene-environment interaction that determines who gets cancer and who doesn't." According to Walker, the increase in frequency and size of the uterine tumors is due to DE...

Emergence of cancer as major cause of childhood death in developing countries is not being adequately addressed

...etic background, environment and lifestyle play in susceptibility to cancer and pathogenesis of particular cancers. Such studies would be easier to conduct if pediatric cancer units are created in resource-poor nations and if their development promotes international cell and tissue banks and the ability to collect ...

UNC launches study of liver injury caused by drugs

...identified by DILIN research will provide clues to susceptibility to the many diseases that represent an interaction with the environment." ...

Chimp genome reveals a retroviral invasion

...d overlap. It could be that African apes evolved a susceptibility to infection, for example, or that humans and Asian apes evolved resistance. A better understanding of the evolutionary history and population genetics of great apes will help identify the most likely scenarios. And knowing how these retroviral eleme...

Ebola virus: from wildlife to dogs

...xistence within this fauna of different degrees of susceptibility to Ebola and, possibly, of strains of various levels of virulence. However, most large primates, once infected, soon die of the disease. Their bodies then become a potential source of contamination for humans, but also for certain domestic animals. E...

Excess liver gene protects against high-fat diet

...tors might lead to differences among them in their susceptibility to high cholesterol and heart disease in a manner dependent on diet. Furthermore, drugs that modulate LXRa activity may have potential as therapies for lipid disorders and atherosclerosis, the group said. "The high-cholesterol, high-fat Western diet...

Any exposure to tobacco smoke during pregnancy is risky

...xposed fetus, affecting survival, birth weight and susceptibility to disease, including cancer." This is a startlingly different conclusion than that reached by three previous studies looking at the potential effects of tobacco smoke exposure to babies in the womb, one of which Dr. Grant co-authored. The primary p...

Depression gene may weaken mood-regulating circuit

...an study suggests that a suspect gene may increase susceptibility to anxiety and depression* by weakening a circuit for processing negative emotion. People with the depression-linked gene variant showed less gray matter and weaker connections in the mood-regulating circuit. How well the circuit was connected accoun...

Achilles heel of the herpes virus possibly found

...h. Its complications can kill, and it may increase susceptibility to many nerve and brain disorders. But until now, scientists haven't fully understood how the herpes simplex virus (HSV) manages to do all of this. And that has stood in the way of developing more targeted, effective treatments against it to help th...

Size matters: Preventing large mammal extinction

...ge to contend with, significantly increasing their susceptibility to extinction. "In a world dominated by people, being big is substantially more of a disadvantage than we realised, which implies that the conservation of large mammals should assume a particular urgency," said Dr Marcel Cardillo of Imperial College...

A novel virus for croup

...ave reported trends in croup, such as the relative susceptibility of boys to the disease, its peak occurrence in the second year of life and its predominance in late autumn and earlier winter, that are matched by patterns of HCoV-NL63 occurrence. This systematic association of croup with HCoV-NL63 is particularly...

Researchers Discover Gene That Determines Asthma Susceptibility By Regulating Inflammation

...ne, Nrf2, plays a critical role in determining the susceptibility to asthma. A research team led by Shyam Biswal, Ph...ty regulated by Nrf2 may be a major determinant of susceptibility to allergen-mediated asthma,?says Biswal. “Nrf2 regulated pathways seem to intervene inflammation at...

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