Shorter colds, milder flu may follow from newly revealed immune mechanism
...halt the infection. Balancing these cell death and survival pathways can determine whether the virus or the ho...some of the first downstream signals that convey a survival message," Holtzman says. "Now, we aim to define more specific signaling proteins that allow the cel...Gene therapy potential for treatment of pancreatic cancer
...ents are still alive five years after diagnosis, a survival rate that has remained static for the past three decades. Currently, the only viable treatment is surgery. Radiotherapy and chemotherapy have little impact on the disease. The research team investigated the potential of the protein vasostatin to su...Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
...ents are still alive five years after diagnosis, a survival rate that has remained static for the past three decades. Currently, the only viable treatment is surgery. Radiotherapy and chemotherapy have little impact on the disease. The research team investigated the potential of the protein vasostatin to su...Compound from marine bacteria shows potential as multiple myeloma therapy
...umor cells, NPI-0052 was well tolerated, prolonged survival and significantly reduced the rate of cancer recurrences. Because NPI-0052 and bortezomib block the proteasome in different ways, the researchers tested them together on myeloma cells. They found that the cancer cells were killed more effectively by ...Molecular research suggest shift needed in how some drugs are created
...y DNA in all living things -- that are crucial for survival against pathogens such as bacteria and fungi. Deficiencies in the system or an over-active response can set the stage for various infections, septic shock and numerous autoimmune disorders. Since researchers at the University of Texas Southwestern i...Islands in the Genome Promote Speciation
... genetic conditions that are not favorable for the survival of hybrid progeny in nature. To study the genetic underpinnings of speciation, the researchers used DNA microarrays to identify global differences in the mosquito genomes. Using a combination of gene chips, statistics, and computational biology, Tur...Adult stem cells aid recovery in animal model of cerebral palsy
... genetic conditions that are not favorable for the survival of hybrid progeny in nature. To study the genetic underpinnings of speciation, the researchers used DNA microarrays to identify global differences in the mosquito genomes. Using a combination of gene chips, statistics, and computational biology, Tur...Implantable pumps extend lives of patients too sick for transplant
...nd that patients who received LVADs had an average survival time of 10.3 months, compared to 3.1 months for th...roduced by WorldHeart, Oakland, Calif. "While the survival time for those patients receiving LVADs was more than three times longer, we even had two patients w...Brainstem blocks pain to protect key behaviors
... eating, drinking and urinating, are so crucial to survival that the brains of all vertebrates contain clusters of nerve cells that can suppress pain long enough to allow the animal to eat, drink -- or pee -- in peace. A report from researchers at the University of Chicago, published early online in the Pr......nvestigating the microbial genes important for the survival and growth of the salmonella pathogen during infection is using this knowledge to generate mutant bacterial strains that may be useful as vaccines. Experiments under way have shown several mutant bacterial strains to be highly effective as vaccines. ...Engineered Stem Cells Show Promise For Sneaking Drugs Into The Brain
... factor in quantities sufficient for improving the survival and function of the defective cells at the root of Parkinson's. "This work shows that stem cells can be used as drug delivery vehicles in the brain," says Svendsen, a professor of anatomy whose laboratory is at the UW-Madison Waisman Center. The ne...UCLA discovery will aid in treatment of patients with a deadly brain cancer
...uch more toxic and less beneficial. With the short survival times associated with glioblastoma, that is critic... will be diagnosed in Americans this year. Average survival is less than a year, according to the American Cancer Society. Although treatment may prolong life, ...Mutations in the BRAF gene predict sensitivity to a novel class of cancer drugs
...rotein that plays a central role in the growth and survival of cancer cells and is mutated in the majority of patients with melanoma and in a minority of patients with colon, breast, and lung cancers. The findings, available in an advance online publication of Nature, represent a potential targeted therapy ta...HIV-infected adults in Botswana respond positively to ARV therapy public treatment program
...laboratory outcomes and two years of follow-up for survival estimates, the majority of enrolled patients on ARV treatment experienced favorable clinical outcomes, including improved CD4 counts, decreased viral load and weight gain comparable with other successful care and treatment programs in the developed w...New Therapeutic Target Identified In Inherited Brain Tumor Disorder
...laboratory outcomes and two years of follow-up for survival estimates, the majority of enrolled patients on ARV treatment experienced favorable clinical outcomes, including improved CD4 counts, decreased viral load and weight gain comparable with other successful care and treatment programs in the developed w...Largest computational biology simulation mimics life’s most essential nanomachine
...laboratory outcomes and two years of follow-up for survival estimates, the majority of enrolled patients on ARV treatment experienced favorable clinical outcomes, including improved CD4 counts, decreased viral load and weight gain comparable with other successful care and treatment programs in the developed w...Gene expression profile helps predict chemotherapy response in ovarian cancer patients
... Prognostic Profile (OCPP), which is predictive of survival in patients with advanced ovarian cancer. (These study results appear in the December 2004 issue of the JCO.) Their work makes use of a DNA technology known as microarray analysis, in which genes expressed by cancer cells are labeled and applied to ...Odd energy mechanism in bacteria analyzed
...tand how it is activated, its role in the life and survival of SAR11, and how it affects ocean ecology.The fin...wever, seems to have a subtle role in the life and survival of SAR11, and appears to be an auxiliary system to aid cell survival." The level of interest in SAR...Researchers uncover mechanisms of estrogen in promoting cell death in breast cancer
...dy. Many breast cancer cells require estrogen for survival (called estrogen receptor–positive breast cancers), and apoptosis of such cells can be induced with treatments that block estrogen, such as tamoxifen, fulvestrant, or aromatase inhibitors. Paradoxically, some cells can become adapted to survive when ...... should recognise the role played by amoeba in the survival of MRSA, and evaluate control procedures accordingly," said Professor Mike Brown from the Department of Pharmacy and Pharmacology at the University of Bath. "Until now this source of MRSA has been totally unrecognised. This is a non-patient source o...