Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance
...But no treatment can substantially enhance patient survival once metastasis has occurred." To simulate the environment in which melanoma naturally arises, the research team introduced one or more cancer-associated genes into human melanocytes, the pigment-producing cells that normally reside in the deepest l...Duke Experiments Boost Radiation's Cancer-Killing Effects
...ith radiation and then blocking their blood vessel survival and re-growth by inhibiting HIF-1," said Moeller. Conversely, when the scientists blocked HIF-1 before radiation, there was no overall inhibition of tumor growth. The tumor's center became "necrotic" or populated with dead cells, but the perimeter o...IBM Transforms the Art of Scientific Expeditions
...ith radiation and then blocking their blood vessel survival and re-growth by inhibiting HIF-1," said Moeller. Conversely, when the scientists blocked HIF-1 before radiation, there was no overall inhibition of tumor growth. The tumor's center became "necrotic" or populated with dead cells, but the perimeter o...Monkeying around to improve organ transplantation
...his approach can induce indefinite organ allograft survival in vivo, in six rhesus monkeys. The authors stimu...olonged ?80 days?and perhaps even indefinite graft survival in three long-surviving animals without administration of additional immunosuppressive agents. This ...When in danger humans are similar to a deer in the headlights
...und that this abrupt reaction, so critical for the survival of some animals, has stayed with humans. Forty-eight male volunteers stood barefoot on a stabilometric platform, to measure balance and body sway, and viewed twenty-four pictures from three different categories. They were: pleasant (sports), neutral...Researchers identify genes associated with lung transplant rejection
...nsplant patients, the biggest barrier to long-term survival is control of rejection," says principal investigator George Caughey, MD, head of Pulmonary and Critical Care Medicine at SFVAMC. "If we know rejection is occurring, we can adjust the patient's medication to try and prevent it. But the problem with l...Deep sea buffet for bone-devouring worms
...aming up with a microbial partner is the secret of survival for many host animals living in such environments. Dr Goffredi says: "Measures of significant population sizes, and the discovery of four additional host species in only three years, suggests that the Osedax worms and their bacterial 'partners' are ...Vineyard weeds found to host Pierce's disease of grapes
...southern San Joaquin Valley vineyards, and compare survival of the infections in selected field and greenhouse-grown plants," said Christina Wistrom, staff research associate in the Department of Environmental Science, Policy and Management, University of California, Berkeley, CA. The study revealed that env...Use of high hydrostatic pressure to inactivate Hepatitis A virus in oysters studied
...n two months, but can linger as long as six. While survival rates for Hepatitis A are above 99 percent, the disease can be very dangerous for infants, the elderly, immunosuppressed people, and those with existing liver disease. Bivalve shellfish, such as oysters, have been demonstrated to concentrate pathoge...Traditional models underestimate extinction rates
...effects of environmental variability on water flea survival to select his models and estimate a range of parameters that might affect extinction, and the other half to test the models' reliability. From the estimated parameters, Drake wrote a computer program to simulate all the possible population outcomes a...Ancient DNA confirms single origin of Malagasy primates
... ultraviolet irradiation, and tropical heat on DNA survival likely contributed to the inability to obtain DNA from some species. The only samples to yield DNA from tropical localities were the two individuals that were used as positive controls, Yoder said. "The results of our study contribute to the mountai...Stem cells bring fast direct improvement, without differentiation, in acute renal failure
...ry of kidney function that is adequate for patient survival depends primarily on the protection and regeneration of destroyed and injured cells. Yet virtually no progress has been made toward development of any highly effective ARF therapy for decades. "Basically, catastrophic loss of kidney function has rem...Long-sought flower-inducing molecule found
...ants in fall. It is absolutely vital for the plant survival to flower at exactly the right time to secure that it can pollinate, or be pollinated, by other plants of the same species. How then does the plant know when to flower? Intense Florigen hunt Already in the 30-ies scientists found out that plants ca...Genes linked to treatment resistance in children with leukemia
...o five percent. In efforts to further increase the survival rate, researchers from St. Jude Children's Research Hospital, the University of Tennessee, and the University of Chicago studied how an individual's genetics might play a role in the effectiveness of chemotherapy drugs. Their findings will be publish...Researchers develop gene therapy to reverse pulmonary arterial hypertension
...tosis in PAH and thus reverses PAH, prolonging the survival of rats. Because this oral therapy has already been tried in humans with congenital mitochondrial diseases, the team is initiating a clinical trial in human PAH. Similarly, newer drugs that inhibit Survivin, currently in trials in oncology, might als...Locusts' built-in 'surface analysis' ability directs them to fly overland
...ea of diffused light," said Dr. Shashar. This is a survival instinct, since if they flew over a body of water, the locusts would be deprived of both nourishment and a place to land and rest. This research, said Dr. Shashar, could be important in providing information that would be useful in developing means f...DNA from feathers tells tale of eagle fidelity
...wise," she said. Those parameters, such as yearly survival rates and ratios of males to females, help conservation biologists monitor populations of rare or endangered species. Noninvasive sampling allows biologists to track changes in populations over time without the risks associated with handling live ani...Forsyth scientists find three bacteria associated with oral cancer
...discovered and treated early, OSCC has a five-year survival rate of 80-to-90 percent. But 60 percent of OSCC cases are not diagnosed until the later stages and fewer than 54 per cent of individuals diagnosed in those stages live for five years¡Xplacing OSCC among the deadliest of cancers. "Far too many peopl...DDT-resistant insects have additional genetic advantage that helps resistance spread
...susceptible strains, the researchers monitored the survival and development rate of all life stages of their offspring. They found that DDT resistance in fruit flies not only carries no cost but in fact confers an advantage when inherited through the female. This discovery comes at a time when a number of d...