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Tag: "suppressors" at biology news

MicroRNAs as tumor suppressors

... (UVA) reveal that microRNAs can function as tumor suppressors in vitro. "Overexpression of HMGA2 is an important feature of many medically important tumors like uterine fibroids,?explains Dr. Dutta. “It is very exciting to realize that microRNAs have an important role in suppressing the overexpression of HMGA...

MicroRNAs can be tumor suppressors

... a form of genetic material, can function as tumor suppressors in laboratory studies. In the May 1 issue of Genes & Development, UVa researchers Drs. Yong Sun Lee and Anindya Dutta have shown that microRNAs can suppress the overexpression of a gene called HMGA2. This gene is related to creation of fatty ti...

Reactivated gene shrinks tumors

... see if the same approach will also work for tumor suppressors other than p53. ...

An AIDS-related virus tricks cells to become tumors, new Penn study finds

...or LANA, tricks the cell into destroying two major suppressors of tumor growth called von Hippel Lindau (VHL) and...n that when LANA expression was blocked, the tumor suppressors again become stable suggesting a direct role of the viral protein in regulation of these major cell ...

Regulating the nuclear architecture of the cell

...le in the suppression of gene expression, known as suppressors of variegation, were named Su(vars). The gene family known as Su(var)3-9 codes for proteins that chemically modify certain histones in the nucleosomes. Su(var)3-9 proteins attach methyl groups to the histone labeled H3 at its ninth amino acid res...

Distinguishing friend from foe in the battle against cancer

...b previously showed that mouse cells lacking tumor suppressors known as TSC genes are more susceptible to the lethal effects of chemotherapeutic agents than are normal cells. Why cells from these TSC null mice were so poorly equipped to survive was not entirely clear. Co-lead authors Sourav Ghosh, Ph.D., and Vi...

Pair of microRNA molecules controls major oncogene in most common leukemia

...tranded RNA molecules that can act either as tumor suppressors or oncogenes. They can block transcription of genes by stopping them from producing messenger RNA or can inhibit translation of the genes by blocking production of proteins from messenger RNA, according to Pekarsky. Earlier this year the investigato...

Activation of microRNA inhibits cancer gene in human cancer cells

... impact regulatory RNAs that may function as tumor suppressors in normal cells and proposes a novel strategy for treating human cancers. DNA methylation and histone deacetylation are epigenetic processes involved in the regulation of gene expression. In the case of cancer, these processes are thought to turn of...

Common molecular 'signature' identified in solid tumors

...s the miRNA signature targets, including the tumor suppressors retinoblastoma-1 (RB1) and transforming growth factor, beta receptor 2 (TGFBR2). Croce predicts that miRNAs themselves may one day be used as treatments. "If we can replace miRNAs that are lost and block those that are overly abundant, then maybe w...

Common molecular 'signature' identified in solid tumors

...s the miRNA signature targets, including the tumor suppressors retinoblastoma-1 (RB1) and transforming growth factor, beta receptor 2 (TGFBR2). Croce predicts that miRNAs themselves may one day be used as treatments. "If we can replace miRNAs that are lost and block those that are overly abundant, then maybe w...

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