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Tag: "suppressor" at biology news

MicroRNAs as tumor suppressors

..., and that the let-7 microRNA functions as a tumor suppressor to prevent cancer formation in healthy cells....

Mailman School of Public Health researchers report blood DNA can be early predictor of liver cancer

..., the scientists examined changes in certain tumor suppressor genes that have been associated with the development of liver carcinomas. This is the first study to prospectively examine potential biomarkers for early detection of liver cancer in high-risk populations, including those with chronic hepatitis B and...

Genetic pathways to curable and incurable forms of pancreatic cancer identified

...n early mutation of Dcp4, in which one copy of the suppressor gene is eliminated, lead to cancer by a different path, beginning with the creation of a distinct class of precancerous lesions in the ductal epithelium called mucinous cystic neoplasms (MCN). This initiates a process that results in the rarer but fa...

In obesity, brain becomes 'unaware' of fat

...e.? The new results also bolster evidence that a suppressor called SOCS-3 may be responsible for the loss of sensitivity to the fat hormone known as leptin. Therapeutic strategies designed to inhibit SOCS-3 may therefore bypass leptin resistance in obese animals to restore energy balance, according to the res...

Study shows big power of small RNAs, not just proteins, in halting cancer

...f micro RNAs (miRNAs) that enable a critical tumor suppressor network, called the p53 pathway, to fight cancer growth. “At CSHL, we are moving simultaneously on several fronts to understand the p53 pathway because damage to this pathway is something that almost all cancers have in common,” said CSHL Cancer Cen...

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