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Tag: "suppressor" at biology news

New binding target for oncogenic viral protein

...f human tumors. "Fbw7 is itself an important tumor suppressor which makes it an attractive choice for inactivati... against malignant transformation, including tumor suppressor proteins p53 and pRb. In the Journal of Biological Chemistry paper, Dr. Welcker and Dr. Bruce Clurm...

Bound for destruction: Ubiquitination protects against improper Notch signaling

...edd4 as an agent of endocytosis. Nedd4’s role as a suppressor of Notchwas illustrated even more plainly when the lab showed that inhibitionof Nedd4 results in the upregulation of ligand-independent activationof the Notch pathway.Nedd4’s place in the greater scheme of Notch signaling became clearerwhen the group...

Genome-wide mouse study yields link to human leukemia

...ecial mice, scientists have discovered a new tumor suppressor gene and a unique chemical signature implicated in... particular stretch of DNA, called Id4, as a tumor suppressor gene. Tumor suppressor genes help control cancer by identifying and getting rid of defective cells ...

Scientists identify molecule that regulates well-known tumor suppressor

...urvival, and is inhibited by activity of the tumor suppressor PTEN. Research indicates that PTEN exerts its tumor suppressor activity by inhibiting PKB/Akt signaling that is critical for cell survival. Many human cancer cells...

New tumor-suppressor gene discovered

...s discovered how the gene works with another tumor suppressor to control tissue growth. The team's genetic and biochemical studies will be published in the 11 March 2005 issue of the journal Cell. "This discovery extends our understanding of how tissue growth is controlled both during normal development and dur...

Chromosome Deletion Predicts Aggressive Neuroblastoma

...pparently removes the protective effect of a tumor suppressor gene, and thereby allows the tumor to grow. Patients in the study with the chromosome deletion had a three-year overall survival rate of 66 percent, compared to 83 percent for patients without the deletion. Dr. Attiyeh's research abstract received t...

NYU and MSKCC research provides model for understanding chemically induced cancer initiation

...n shape in a carcinogen-damaged DNA site--in tumor suppressor genes altered by a known cancer-causing chemical f...ent. The studied gene, p53, is an important tumor suppressor gene that plays critical roles in cellular functions such as cell-cycle control, differentiation, an...

NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses

...on even though the mice were missing two key tumor suppressor genes (p27 and APC) and were fed a diet high in fa...dac offers protection against both a lack of tumor suppressor genes as well as poor diet," says the lead author, WanCai Yang, M.D., an assistant professor of medi...

Disease progression model of pancreatic cancer developed by Penn researchers

...m additional acquired mutations in known key tumor suppressor pathways, Hingorani suggests, "there may actually be unique genetic routes to pancreatic cancer, such that not all pancreatic cancers are equivalent." The development of the first animal model for pancreatic cancer that fully imitates the progressio...

Unchecked DNA replication drives earliest steps toward cancer

...cancer as mutations in specific oncogenes or tumor suppressor genes. Full-blown tumors and metastatic cancers, h...ions in a certain few genes, such as the p53 tumor suppressor gene, are found in so many different cancers. Mutations in p53 are found in the majority of human ca...

Ancient immune defense mechanism is no match for HIV-1

... transcriptional activator, also can function as a suppressor of RNA silencing (SRS). Tat helps HIV-1 to elude the cell's natural RNAi defense by interfering with the ability of Dicer to process dsRNAs. "Our results suggest that the dynamic interplay between RNAi and SRS remains physiologically conserved from ...

Natural tumor suppressor in body discovered by UCSD medical researchers

A natural tumor suppressor that could potentially be turned on in certain can... Phosphatase (PHLPP, pronounced "flip"), the tumor suppressor is described in the April 1, 2005 issue of the journal Molecular Cell. The scientists demonstrated t...

Cancer related gene p53 not regulated as indicated by previous tissue culture research

...maged DNA to self-destruct pivots on the p53 tumor suppressor gene. If p53 is inactivated, as it is in over half...sures. When higher than normal levels of p53 tumor suppressor exist, there is enough p53 to bind to many regulatory sites in the cell's genome to activate the pro...

Mosaic mouse technique offers a powerful new tool to study diseases and genetics

...l gene is lost. For example, if you delete a tumor suppressor gene, the green cells will proliferate, and you can actually study the tumor's progression. If you can image these cells in a live animal, you can potentially watch the tumor grow." Luo points out that MADM is more precise than the widely used "knoc...

Most common lung cancers may begin in newly discovered cells

...rly, and if the mutation happens to affect a tumor suppressor gene or oncogene, it could start the process of forming a tumor. There are certainly suggestions that various tumors might arise in locations where there has been a previous injury." The researchers acknowledge that the ultimate stem cell test remai...

Biased reporting found in cancer prognostic studies

...ished studies alone have focused on a single tumor suppressor protein (TP53) that may predict the outcome of a patient with head and neck cancer. As researchers attempt to make sense of the growing mountains of information, some are beginning to question the validity and possible biases in many of the studies. ...

Engineered skin offers clues to melanoma development

...terfere with the retinoblastoma (Rb) and p53 tumor suppressor pathways, which normally act to keep cell growth in check, as well as human telomerase reverse transcriptase (hTERT), the enzyme that protects the ends of chromosomes during cell division. This enzyme is associated with the progression of many cancer...

Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack

...terfere with the retinoblastoma (Rb) and p53 tumor suppressor pathways, which normally act to keep cell growth in check, as well as human telomerase reverse transcriptase (hTERT), the enzyme that protects the ends of chromosomes during cell division. This enzyme is associated with the progression of many cancer...

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

...terfere with the retinoblastoma (Rb) and p53 tumor suppressor pathways, which normally act to keep cell growth in check, as well as human telomerase reverse transcriptase (hTERT), the enzyme that protects the ends of chromosomes during cell division. This enzyme is associated with the progression of many cancer...

Duke Experiments Boost Radiation's Cancer-Killing Effects

...y hypoxia. Similarly, tumors with an intact tumor suppressor gene known as p53 respond more readily to radiation and to HIF-1 inhibition than tumors with a mutated P53 gene. Understanding such factors can aid scientists in determining the best conditions under which to inhibit HIF-1. "We want to maximize the b...

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