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Tag: "suppression" at biology news

Study shows big power of small RNAs, not just proteins, in halting cancer

...lead to a deeper understanding of a critical tumor suppression mechanism but also may provide insight into how to best engage the p53 pathway to treat cancer by killing tumor cells,” said He. ...

Potato wart eyed as risk to potato production

...lack of suitable chemical controls for potato wart suppression make this disease especially problematic for any t...ping and improving reliable and integrated disease suppression methods to directly deal with this disease," said Franc....

Human stem cell treatment restores motor function in paralyzed rats

...gnificantly improved motor function, measured by a suppression of spastic movements and improved muscle tone, was shown in 40 to 50 percent of the animals tested. A post-mortem study of those animals showed a robust maturation of neurons and an increase in the expression of inhibitory neurotransmitters in the s...

Targeting sugar on blood vessels may inhibit cancer growth

...ster said. "Altering this binding would allow for suppression of a broader array of the tumor ‘fuels?for angiogenesis, without a major effect on normal vascular function." The researchers hope to develop novel therapies by inhibiting endothelial heparan sulfate in the tumor environment. An example would be ...

LIAI scientists make important finding on cytomegalovirus transmission

...p will be conducting animal studies with the IL-10 suppression and the OX40 enhancement combined into one treatment. "We tested them separately, but they may well be even more effective when combined," Croft said....

Natural gut hormone offers hope for new obesity drug

...ch they believe may provide a solution to appetite suppression and is the most likely candidate for translating into a treatment. "Developing a treatment based on natural appetite suppression, mimicking our body's response to being full, has the potential to be safe and effective," says Professor Bloom. "We b...

Parasite infection may benefit MS patients

...er a potential explanation for environment-related suppression of MS development in areas with low disease prevalence." ...

Resistance to anti-HIV drugs in Uganda developed due to drug supply problems

...f the patients had near perfect adherence and full suppression of the virus?but about supply interruptions that l...ffective at suppressing the virus, with full viral suppression in over 80 percent of people on treatment for 6 months. Resistance developed in people during treatm...

St. Jude announces breakthrough in eye cancer treatment

... control of infections caused by treatment-related suppression of the immune system. However, most of the 5,000 children worldwide who are found to have retinoblastoma live primarily in countries with limited resources and have restricted access to medical treatment, according to Carlos Rodriguez-Galindo, M.D., ...

Peering into the shadow world of RNA

...he genome’s integrity is critical.? One of these suppression mechanisms involves short interfering RNA, or siRNA, a form of non-coding RNA that specifically targets and inactivates the stretch of DNA from which it originated. In the case of transposons, this would effectively limit their ability to act, thus p...

Rearing an army to save wheat

...arasitic wasps are part of the naturally occurring suppression of wheat stem sawfly that varies greatly from field to field throughout Montana. The wasps produce two generations of offspring a year, compared to only one for the wheat stem sawfly. A number of Montana counties now have established populations o...

'Erectile dysfunction' drugs heighten natural anti-cancer activity

...ide synthase -- which are key to triggering immune suppression via MDSCs. Borrello’s team found that the arginase enzyme, which metabolizes a dietary supplement called L-arginine, also contributes to dampening the immune system through MDSCs much like nitric oxide, and its production can be reversed by sildenaf...

Regulating the nuclear architecture of the cell

...y identified in Drosophila as having a role in the suppression of gene expression, known as suppressors of variegation, were named Su(vars). The gene family known as Su(var)3-9 codes for proteins that chemically modify certain histones in the nucleosomes. Su(var)3-9 proteins attach methyl groups to the histo...

Novel regulatory mechanism identified for key tumor suppressor p53

...nostic marker for cancer." Responsible for tumor suppression throughout the body, the p53 protein has been found to be mutated and dysfunctional in more than half of human cancers. When working properly, p53 acts by binding to DNA to activate genes that direct cells with damaged DNA to cease dividing until the...

Buildup of damaged DNA in cells drives aging

..., or progeroid, mice and naturally old mice is the suppression of genes that control metabolic pathways promoting... the same age. This comparison revealed a profound suppression of genes in several important metabolic pathways in the progeroid mice. Most notably, the progeroid ...

Recycled paper and compost could both be key tools to control plant disease

...r, which is what you need for plant growth". The suppression of plant diseases was particularly noticeable when the green and recycled paper composts were added to peat. Peat is used by many growers as it provides a clean and uniform material that is suitable for plant growth ?but its very cleanliness makes th...

Dominant meerkats render rivals infertile

... unusual in this regard, or whether stress-related suppression is actually a more widespread phenomenon in animal societies than was previously recognised". Dr Andrew Young's research is part of the Kalahari Meerkat Project, located at the Kuruman River Reserve, South Africa. The project is a decade-old initi...

Researchers find 'secret weapon' used by SARS virus

...t set of SARS coronavirus proteins. "He found this suppression of host gene expression, and then he designed several elegant experiments that showed it was caused by RNA degradation, something never before seen in an RNA virus." Exactly how that degradation takes place, how an RNA virus can preserve its integ...

HIV-1's high virulence might be an accident of evolution

... Ulm in Germany and his colleagues. "Nef-mediated suppression of T cell activation is a fundamental property of ...d death. "Intriguingly, this loss of Nef-mediated suppression of T cell activation appears to have occurred twice, once in the ancestor of a group of viruses infe...

Invasive species alter habitat to their benefit

...ch as the use of fertilizers and road salt and the suppression of natural wildfires, also may result in environmental changes that affect species diversity. "My question was, are humans causing the changes, or are the invaders?" Farrer said. "Finding the answer has practical implications: if you're trying to r...

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