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Tag: "suppressing" at biology news

Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease

... that regulate HOX genes are capable of causing or suppressing tumors. Technological breakthrough Bernstein has been studying chromosome wrappings for five years as a postdoctoral researcher in the lab of Stuart Schreiber. Together they worked out techniques to examine the way genes are packaged in yeast. To g...

Scientists identify genetic pathways essential to RNA interference

...s were essential to the RNAi process that had been suppressing expression of the fluorescence gene. Some of the ..., it has not yet been effective for experimentally suppressing gene expression in living mammals. Identifying each step in the RNAi process could lead to more succ...

Studies reveal methods viruses use to sidestep immune system

...producing interferon, which neutralizes viruses by suppressing their replication. The researchers also investigated why cells with functioning RIG-I protein still had persistent HCV infection. In a study to appear in PNAS, Dr. Gale and his group found an explanation for HCV's tenaciousness. Once HCV infects the...

Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries

...fat food. "This was dramatic evidence that showed suppressing AIM function translates into prevention of atherosclerosis," Dr. Miyazaki said. Atherosclerosis, known as "hardening of the arteries," occurs when the inside walls of an artery become thicker and less elastic. This narrows the space for blood flow ...

Scientists identify genetic pathways essential to RNA interference

...s were essential to the RNAi process that had been suppressing expression of the fluorescence gene. Some of the ..., it has not yet been effective for experimentally suppressing gene expression in living mammals. Identifying each step in the RNAi process could lead to more succ...

NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses

...he p21 gene, this can have an overriding affect on suppressing tumor formation caused by either loss of other tumor suppressor genes or diet," says Yang. "We are testing this concept further, including exactly how the p21 gene gets activated." ...

Blink, and the brain misses it

...ents or objects in the outside world. "Transiently suppressing these brain areas involved in visual awareness during blinks may be a neural mechanism for preventing the brain from becoming aware of the eyelid sweeping down over the pupil during a blink and the world going dark," explains Professor Frith. In summ...

Major breakthrough in the treatment of cancers and infectious diseases

...lations, Dr. Veillette's team has established that suppressing EAT-2 results in the production of NK cells that are much more effective at killing cancer cells. Inhibiting the function of EAT-2 with medications could therefore stimulate the killer function of NK cells, and increase their capacity to destroy canc...

A protein in the eye may prevent immune response and protect eyes from disease

...by which F4/80 stimulates the production of immune suppressing T Cells is unknown, the team believes that the protein may be involved in cell-cell communications. The presence of F4/80 cells in other immune privileged sites, such as the brain and placenta, and its exclusion from T cell zones in the spleen sugge...

New type of rejection blocker protects kidneys after transplant

...s that must be taken daily to prevent rejection by suppressing the immune system's hostile response to a transpla...atacept prevents destruction of the kidney without suppressing the immune system's response to viruses and other pathogens. Belatacept is based on research into t...

Molecular miners find pain relief drugs from the sea

...ic in our society the need for more effective pain suppressing compounds is a priority. ACV1 may fill this unmet need," Associate Professor Livett says. ...

Retina adapts to seek the unexpected, ignore the commonplace

... the visual scene, highlighting key features while suppressing the less interesting regions." These findings provide evidence that the ultimate goal of the visual system is not simply to construct internally an exact reproduction of the external world, Meister and his colleagues write in Nature. Rather, the sys...

Researchers develop gene therapy to reverse pulmonary arterial hypertension

...or programmed cell death--which promotes cancer by suppressing the body's ability to limit excessive cell growth. Armed with this new information and using animal models, the researchers developed a nebulized and inhaled gene therapy to deliver an inactive Survivin-mutant via a virus--known in science as a "dom...

Hepatitis C complicated by morphine withdrawal

...hat morphine withdrawal complicates hepatitis C by suppressing IFN-alpha-mediated immunity and enhancing virus re...showing that withdrawal promotes HCV expression by suppressing anti-HCV factor (IFN-alpha) production by liver cells suggests that �opioid abuse may contribute to ...

Texas scientists discover how a hepatitis C protein promotes liver cancer

...roteins targets a cell protein that is crucial for suppressing the development of tumors, interfering with its ability to control cell proliferation," Lemon said. "By knocking out this 'tumor suppressor' and promoting the proliferation of liver cells, this viral protein is setting up the liver for cancer." Acco...

HIV accessory protein disables host immunity via receptor-protein intermediary

...y regulating cell differentiation, cell death, and suppressing host-cell immune response proteins. Weiner's group found that Vpr binds to the glucocorticoid receptor, but it remained unclear whether the GR pathway was required for Vpr to commandeer the host cell's machinery. "We started to realize a few years ...

How can we protect patients with weakened immune systems from influenza?

...oth chemotherapy and stem cell transplants involve suppressing the patients' immune defenses. A third group of patients has chromosome 22q.11.2 deletion syndrome, a congenital multisystem disorder that impairs the immune system. Children's Hospital is a world leader in studying and treating this syndrome. Three...

Losing sleep undoes the rejuvenating effects new learning has on the brain

...tial benefit of new learning on the hippocampus by suppressing neurogenesis. "Mild, chronic sleep restriction may have long-term deleterious effects on neural functioning," according to the paper. On the other hand, that sleep-deprived rats did better on a task requiring use of visual and odor cues compared to ...

Viral 'fitness' explains different resistance patterns to aids drugs

...ical Center. When patients succeed in completely suppressing HIV, which requires that patients take all or almo...al drugs (ARVs) with demonstrated effectiveness in suppressing the HIV virus when taken in combination with other ARVs at high levels of pill-taking as directed. T...

Biologists develop genome-wide map of miRNA-mRNA interactions

... results confirmed the role of specific 3' UTRs in suppressing gene expression even more widely than predicted by the computational analysis, suggesting that 3' UTRs contain a largely unexplored universe for gene regulation. The thousands of genome-wide miRNA target predictions for nematodes, or roundworms, hu...

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