suppress 2 4

Tag: "suppress" at biology news

Loosen up, DNA: Leukemia gene changes genetic packaging

...that is unavailable, known as heterochromatin, can suppress tumor growth by keeping genes that tell cells to g...cer directly, or knock out genetic mechanisms that suppress cancer. "A molecule that is both an oncogene and that also antagonizes a tumor suppressor mechanis...

Leptin found to control appetite and limb development in frogs

...nd other mammals, leptin acts on the frog brain to suppress appetite. But the hormone also seems to play a role in the complex signaling that turns a finned tadpole into a four-legged frog, according to Robert Denver, an associate professor of biology at the University of Michigan. Denver's team gave frogs a...

How bad is malaria anemia? It may depend on your genes

...ponse to inflammation called MIF, which appears to suppress red blood cell production in people whose red blood cells already are infected by malaria parasites. The parasite that causes malaria - known as plasmodium - is carried through blood by mosquito bites, and in parts of the world where mosquitoes th...

Scientists tie several cancers to common 'oncogene engine'

...rcoma. While no drug currently exists to directly suppress MITF, the identification of MITF's role opens a door to potential therapies because the researchers have identified some of the genes and proteins that MITF regulates that new drugs could be used to block. One of the targets is Bcl-2, which enables c...

Recycled paper and compost could both be key tools to control plant disease

... compost contains a diversity of microbes that can suppress plant diseases. The ecological benefits of this are obvious: less fungicide has to be applied to plants, less peat is required thus preserving peat bogs, and green waste and paper waste that would otherwise be land-filled is recycled. Professor Ra...

Scientists find a key to immune system's ability to remember

...nt patients require life-long regimens of drugs to suppress immune response to the foreign cells in the donated organ. ...

New path from estrogen to survival in breast cancer cells described

...ey looked at how this NEDDylation further works to suppress the ability of NFkB to transcribe (activate) other...dified BCA3, it binds to p65 and recruits SITR1 to suppress NFkB-mediated transcription," Yeh said. Finally, the researchers discovered that estrogen blocks N...

Human testis harbors HIV-1 in resident immune cells

...ve antiretroviral therapy (HAART) can successfully suppress virus in the blood. The presence of HIV in the semen despite successful HAART has intrigued scientists. Researchers led by Dr. Nathalie Dejucq-Rainsford examined testis tissue for the presence of HIV receptors. They found that all of the necessar...

Mirrors in the mind: New studies elucidate how the brain reflects onto itself the actions of others

...serving actions interpreted as one's own tended to suppress motor facilitation. Taken together, the findings indicate that the observation of others facilitates the motor system. The authors point out that the findings also suggest that the neural mechanisms that underlie action observation are intrinsically ...

Two-faced protein can stop metastasis or promote it, researchers say

...e says. "This means that E-cadherin normally helps suppress invasion." But researchers have noted that the p120 catenin protein seems mysteriously two-faced: while it normally strengthens cell-cell bonding, in some cases it can also negatively affect cell adhesion. They also have found that over production o...

Pair of microRNA molecules controls major oncogene in most common leukemia

... of two miRNAs known as miR-29 and miR-181 seem to suppress expression of the TCL1 oncogene that drives the most aggressive forms of the leukemia, said the study’s lead author, Yuri Pekarsky, Ph.D., assistant professor in the Department of Molecular Virology, Immunology and Medical Genetics at Ohio State Univ...

Researchers create genetically matched embryonic stem cells for transplantation

...d tissues formed, with no rejection and no need to suppress the recipients' immune system. Daley's laboratory at Children's Hospital Boston is now trying to replicate its results with human eggs. As Daley noted, there are several potential limitations to embryonic stem cells generated by parthenogenesis. ...

HIV exploits competition among T-cells

...produced in response to a first viral infection to suppress the creation of new immune cells in response to a second infection by a related strain. The second type of competition, immunodominance, occurs when several viral strains simultaneously infect one person. In this case, T cells compete to recognize th...

Researchers discover key mechanism by which lethal viruses Ebola and Marburg cause disease

...es that resemble proteins in retroviruses known to suppress the immune system. By targeting these amino acids, new drugs could disrupt the ability of these viruses to shut down immune systems and make them vulnerable to the body's natural defenses. "This brilliant study shows that many viruses, including...

Does natural selection drive the evolution of cancer?

...o divide as healthy cells do, and they are able to suppress a vital set of internal instructions that require cells to self-destruct when their genes are mutated beyond repair. This protective cell-suicide program carried by normal cells is known as apoptosis. Seeing a tumor in this light opens a window on...

New engineered drug may offer prolonged arthritis relief

...her the fusion protein would retain the ability to suppress IL-1 activity and fight inflammation. The researchers treated human white blood cells with either the original or the modified drug. White blood cells are responsible for mounting the body's immune response and normally react to IL-1 by growing in ...

Leading reason for corneal transplants comes into focus

...s looking to one day use various gene therapies to suppress the mutations that he has found. It is hoped that someday the millions of people who suffer from FCD in the United States will eventually benefit from having the genetic basis of their disease identified and gene therapies developed. At present, corn...

Hormone linked to brain's cravings for food and other energy sources

...ly block ghrelin in this part of the brain, we can suppress feeding or the need to seek out food and energy," said Horvath. "It also suggests that perhaps it could interfere with the need to seek out drugs as well." Horvath said ghrelin, which was originally found to signal in the hypothalamus, has now bee...

T for two: Scientists show how immune system chooses best way to fight infection

...ck infected cells, and "regulatory T cells", which suppress the immune system, protecting the body from inflam...ven to individuals receiving transplants, may help suppress the rejection response. Now, a team of researchers has discovered a novel mechanism determining w...

T-beta-RIII joins the fight against breast cancer

...ough the soluble factor TGF-beta has been shown to suppress the growth of tumor cells in the early stages of breast cancer, high levels of TGF-beta during the later stages of the disease are associated with a poor outcome. A study using human breast cancer samples and mice, which appears online on December 7 ...

1 2 3 4 5 6