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Tag: "suppress" at biology news

Living taste cells produced outside the body

...w taste stimuli interact to enhance good tastes or suppress unpleasant tastes. Similarly, new molecules, including potential artificial sweeteners or bitter blockers, can be evaluated to see if they interact with taste receptors to activate the cell. Another important avenue for research aims to help people...

Marijuana-like compounds suppress the immune response

...on and inflammation. Because cannabinoids seem to suppress activated white blood cells, Tohyama believes they could have a potential use in the treatment of inflammatory diseases. ...

Boosting newborns' immune responses

... adenosine alters the physiology of white cells to suppress production of TNF-alpha (but not of IL-6) when TLR...erns may serve an evolutionary purpose. Nature may suppress babies' production of inflammatory cytokines like TNF-alpha and IL-12 before birth because they can ...

Study finds drug may cut down involuntary movements

...ugs like haloperidol (Haldol) are commonly used to suppress chorea, but they cause many different side effects. This study shows that tetrabenazine can decrease chorea, and the drug is well-tolerated by most research subjects," said Shannon. Tetrabenazine was originally developed in the 1950s to treat psych...

New compound stops brain cell degeneration in Alzheimer's disease

...lly administered compound specifically targeted to suppress brain cell inflammation and neuron loss associated...ates that targeting excessive glial activation can suppress brain inflammation and neuron dysfunction in the hippocampus and protect against cognitive decline i...

International HIV/AIDS trial finds continuous antiretroviral therapy superior to episodic therapy

...ral therapy (ART) was taken on an ongoing basis to suppress HIV viral load; or a drug conservation strategy, in which ART was started only when the levels of key immune cells, called CD4+ cells, dropped below 250 cells per cubic millimeter (mm3). Volunteers in the drug conservation group were taken off ART--w...

Tiny RNA molecules fine-tune the brain's synapses

...RNAs, tiny, recently discovered RNA molecules that suppress gene expression. Increasing evidence indicates a role for microRNAs in the developing nervous system, and researchers from Children's Hospital Boston now demonstrate that one microRNA affects the development of synapses ?the points of communication ...

Why nerve cells work faster than the theory allows

... help the cells transmit fast changing signals and suppress slow signals. Every living cell maintains a voltage difference across its cell membrane. Nerve cells distinguish themselves from other cells in that they use this voltage difference to process and transmit messages. When a nerve cell receives an im...

Mystery solved: Gold's power against autoimmune diseases defined

...took a large-scale search for new drugs that would suppress the function of an important component of the immune system, MHC class II proteins, which are associated with autoimmune diseases. MHC class II proteins normally hold pieces of invading bacteria and virus on the surface of specialized antigen present...

One big biology question solved

...the case of an infertile couple wanting a baby, or suppress it, in the case of pest management. Professor Koopman also suggested that an inappropriate retinoid signal might give the wrong instructions to germ cells, which could lead to the formation of germ cell tumours. "Our research has suggested a poss...

Just the expectation of a mirthful laughter experience boosts endorphins 27 percent, HGH 87 percent

...o can offset symptoms of chronic stress, which can suppress various components of the immune responses, particularly those related to anti-viral and anti-tumor defenses. In addition, there appears to be a rebalancing of the Th1/Th2 immune response which suggestively could lead to reduction of autoimmune issue...

Speeding discovery of the 'human cancer genome'

...r-causing genes or the loss of genes that normally suppress tumor formation. But as genome technology continues to improve, providing ever-increasing resolution, researchers have found more than they had expected, Chin said. In human melanoma, for example, more than 100 genomic regions exhibit recurring...

RNA interference stops colon cancer spread in mice

...hway that is activated in a number of cancers, and suppress the spread of colon cancer in experimental animals," said UTMB professor of surgery B. Mark Evers, senior author of a paper on the research published in the June issue of Annals of Surgery. "Over the last couple of years people have talked a lot abou...

Parkinson's disease mechanism discovered

...egulating trafficking could also be switched on to suppress alpha-synuclein toxicity in yeast cells. "Our fin...ded to test whether enhancing Ypt1p activity would suppress alpha-synuclein toxicity in animal models of the disease. Fortunately, we had an excellent team of c...

Scientists stop autoimmune disease without shutting off immune system

...ction. The development of drugs that completely suppress the immune system offered a lifeline to patients with pemphigus vulgaris (PV) and other autoimmune disorders, but the drugs themselves can be lethal and often cause serious side effects. Now, researchers at the University of North Carolina at Chapel...

Friendly bacteria in chewing gum that bites back

... antimicrobial properties, have also been shown to suppress the bacteria that fight tooth decay. Other potential uses of Lactobacillus include the prevention of body odour. BASF are looking into producing a deodorant based on L. aladoris, which can inhibit odour-producing bacteria in the armpit. Similarly, ...

Researchers seek to solve mystery of natural HIV control

...few HIV-infected individuals are naturally able to suppress replication of the virus. The Elite Controller Co...t cure or prevent infection but could successfully suppress viral levels. Since this natural ability is so rare, we need to work with collaborators around the ...

EGF receptor activation prevents microbes from going more than skin deep

...dermis of wounded skin exceeded those necessary to suppress or prevent the growth of foreign microbes. The results of this study demonstrate that wounding of the skin alone, without the presence of microbes, is sufficient to activate defense mechanisms in the skin that can prevent microbial growth and related...

Tumor wizardry wards off attacks from the immune system

...r immunotherapy. We want to find a way to actively suppress T-reg cells and at the same time actively evoke an immune response to tumor-specific antigens." In collaboration with other researchers at the School of Medicine, Linehan is planning to set up a clinical trial that pairs T-reg depletion with anti-c...

HIV-1's high virulence might be an accident of evolution

...s, including the less virulent human strain HIV-2, suppress the expression of a receptor normally found on the surface of T cells, making the immune cells less responsive to activation, the researchers found. In contrast, they report, the nef gene of HIV-1 and a subset of closely related SIVs failed to limit ...

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