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Tag: "suppress" at biology news

Suppressing growth hormone in early adulthood may prevent cancer

... the somatostatin class are currently available to suppress growth hormone and IGF-1 in people, so somatostatin analogs could be given as preventative measures to lower plasma IGF-1 before the onset of disease, especially in high-risk people. In a previous study, rats with high levels of growth hormone (a ci...

Retina adapts to seek the unexpected, ignore the commonplace

...ly rare horizontal features, the retina adjusts to suppress the routine vertical features while highlighting the singular horizontal elements. Meister and his co-authors examined neural signals in retinal ganglion cells, which convey visual images from the eye to the brain. These cells generally record local...

Drugs from the deep blue

...e from drugs given to organ transplant patients to suppress the immune system, to treatments for high blood pressure and heart disease. Pessah's research group works with calcium channel modulators and other biomolecules derived from plants and scorpion venom. But when Pessah and Molinski got to talking at a...

Techniques available to detect soil that inhibits destructive soybean pest

...ques are available to find soils that specifically suppress these microscopic roundworms, said Andreas Westpha..." Westphal said. "We promote conditions in soil to suppress the nematode, and we also study the soil so that we can determine the mechanisms that create suppres...

Grasshopper love songs give insight into sensory tuning

...gth of those connections adaptively, to amplify or suppress connections. Some four decades ago, a general principle called the "efficient coding hypothesis" was formulated, holding that sensory systems adjust to efficiently represent the complex, dynamic sounds, sights, and other sensory input from the enviro...

Dendritic cells offer new therapeutic target for drugs to treat MS and other autoimmune disease

...rrent therapies, such as steroids, are designed to suppress T-cell responses. But the Hopkins investigators believe that targeting dendritic cells may stop the faulty immune response at a higher "upstream" level since T-cells frequently receive their information from dendritic cells. Testing their idea, Sma...

MicroRNAs have shaped the evolution of the majority of mammalian genes

...an bind to a short sequence on a targeted mRNA and suppress protein production. In a paper published last Ja...e mature muscle cells, microRNAs are activated and suppress genes that are no longer needed at such high levels in the mature muscle. "Many of these evolutiona...

New cell transplantation technique restores insulin production in diabetics

...le placement. "We used a steroid-free protocol to suppress the immune system, so that the body accepted the transplanted cells," Dr. Krishnamoorthy said. "We also developed a 'sandwich technique' to close the access site through the skin, where the islet cells are injected. The sandwich technique is so-calle...

Stem cells' electric abilities might help their safe clinical use

... "Our findings may lead to genetic strategies that suppress undesirable cell division after transplantation, not only for ESCs and their derivatives, but perhaps for adult stem cells as well." Li adds that much more work is necessary to know for sure. ...

Building a better mouse model of lung cancer: FHIT counts

... very low levels of the protein might be enough to suppress or even prevent lung cancer," says Huebner. Huebner had a hunch that pairing loss of protein with the loss of another tumor suppressor might enhance the research value of the new mouse model even more, so the research team bred another strain of mic...

Sickle cell disease corrected in human models using stem cell-based gene therapy

...bedded small interfering RNA precursor designed to suppress abnormal hemoglobin formation. Tested in adult st...had two functions -- produce normal hemoglobin and suppress the generation of sickle shaped hemoglobin S. The therapeutic gene was engineered into a lentiviral ...

New study expands understanding of the role of RNA editing in gene control

...to specific RNA editing, the result of which is to suppress miRNA expression and its activity. The importance of understanding these joined processes can be seen in the fact that roles have been identified for miRNAs in embryonic development, cell and tissue differentiation, and, increasingly, in cancer form...

New view of cancer: 'Epigenetic' changes come before mutations

...the turning off or quieting of genes that normally suppress cancer and the turning on of oncogenes to produce proteins that set off malignant behavior. Epigenetic changes are found in normal cells of patients with cancer and are associated with cancer risk, Feinberg notes. As one example, in a study publish...

Penn study finds direct role for glial cells in brain cross-talk

.... This helps explain why high adenosine levels can suppress epileptic seizures. In contrast, low levels of adenosine increased the transmission of nerve impulses. The modulation of neuronal activity through the regulation of the level of adenosine in the synapse may explain the nature of wake-to-sleep tran...

Gene therapy potential for treatment of pancreatic cancer

...tigated the potential of the protein vasostatin to suppress the development of new blood vessels and pancreatic tumour cells both in test tubes and in mice with pancreatic cancer. 'Solid' tumours, such as pancreatic cancer, are heavily dependent on a rich blood supply to enable them to grow rapidly and sprea...

Jefferson researchers find nanoparticle shows promise in reducing radiation side effects

...tigated the potential of the protein vasostatin to suppress the development of new blood vessels and pancreatic tumour cells both in test tubes and in mice with pancreatic cancer. 'Solid' tumours, such as pancreatic cancer, are heavily dependent on a rich blood supply to enable them to grow rapidly and sprea...

Brainstem blocks pain to protect key behaviors

...rtebrates contain clusters of nerve cells that can suppress pain long enough to allow the animal to eat, drink...active during slow-wave sleep. "OFF" cells, which suppress pain, are active during slow-wave sleep. Foo and Mason, who completed her post-doctoral training i...

Researchers discover new form of cancer gene regulation

...on in mice that causes rapid tremor, is thought to suppress tumor formation and protect humans from cancer. Now, a team of researchers from Northwestern University and the University of Wisconsin has shown that the Quaking gene likely suppresses tumor growth by inhibiting production of a protein associated ...

The reason why antiviral therapy can't annihilate HIV infection, and what to do about it

Antiviral therapy has been used to suppress HIV replication and has dramatically improved the clinical course of disease in affected patients. But the existence of viral reservoirs precludes the complete elimination of HIV from treated patients. In a new study appearing on November 1 in The J...

Infection 'alarm' yields clues to immune system behavior

...ng target for new medications designed to boost or suppress the immune system, the researchers said. An overactive immune system, for example, can set off the excessive inflammation associated with rheumatoid arthritis and lupus. In addition, some cancers are more likely to grow where inflammation occurs. The...

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