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Tag: "suppress" at biology news

Source of molecular triggers in cutaneous T cell lymphoma identified

... become functioning regulatory T (Treg) cells that suppress the immune responses of normal T cells to microbial agents. This may explain the susceptibility of patients with extensive CTCL to opportunistic infections. "Through understanding T cell and dendritic cell interactions, we may gain the ability to ma...

Novel antiviral technology inhibits RSV infection in mice

...lungs. The RNA produced isspecifically designed to suppress the protein NS1. Without NS1, thehost antiviral defense remains intact and the virus cannot reproduce.Mice treated intranasally with the gene-silencing nanoparticles, beforeand after infection with RSV, showed significantly lower levels ofvirus in th...

Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease

...Many of the proteins that regulate these genes can suppress or enhance tumor growth," Bernstein notes. "Some of the genes can cause cancer directly when altered by mutations." "The work we're doing now is very fundamental," he says. "But what we learn about the interactions between chromatin, its tags, and v...

Opposing fat metabolism pathways triggered by a single gene

...omposition of fats in the nematode. Using RNAi to suppress gene expression, the researchers discovered that when nhr-49 was absent, the lifespan of the nematode was reduced by more than 50%, and the animal displayed numerous gross abnormalities in the gut and gonad. This was accompanied by unusually high fat...

Chemists identify immune system mechanism for methamphetamine binges

...ers have documented the drug's apparent ability to suppress the immune system, making abusers more vulnerable to diseases such as HIV. The new study is the first to suggest that the drug can engage the body's defense system to attack methamphetamine in such a way that makes users inclined to use more of the d...

Molecular models advance the fight against malaria

...or using these models to test new drugs that could suppress malaria's ability to mutate against current therapy. "This is the first quantitative explanation for malaria's drug resistance," said Dr. Bernard Trumpower, professor of biochemistry at Dartmouth Medical School and head of the study. "In addition to ...

Multi-purpose protein regulates new protein synthesis and immune cell development

...the IRE1 signaling pathway may lead to new ways to suppress B cell development, which could be helpful in autoimmune diseases like diabetes and lupus." ...

Yeast Network Prevents Damage By Oxygen Radicals

... now identified a group of genes that cooperate to suppress DNA mutations and the genome rearrangements that are the hallmarks of cancer cells that occur in response to ROS." Dr. Kolodner and lead author, Meng-Er Huang, generated various yeast strains each with a mutation in the TSA1 gene, which results in i...

New tumor-suppressor gene discovered

...llenge of discovering how the mats gene is able to suppress the growth of tumors. "We did not find many clues when we compared the sequence of the mats gene with the sequence of other genes in the public databases," Lai says. "But we did find a counterpart to the mats gene in yeast. This yeast counterpart is ...

Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

...w studies came out that showed that microRNA could suppress translation in certain Drosophila (fruit fly) genes if those genes contained sequences complementary to the microRNA's sequence. But finding the targets of these microRNA proved difficult, and by the turn off the century, only a few had been identifi...

Researchers find promising cancer-fighting power of synthetic cell-signaling molecule

Novel anti-cancer compounds called Enigmols suppress the growth of human cell lines representing cancer...ed by the National Cancer Institute. "Many agents suppress cancer cells in a Petri dish and then not in the whole animal, or have unacceptably high toxicity fo...

NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses

... sulindac, an agent they had previously found help suppress tumor formation. To their surprise, none of the knock-out mice developed cancer. "To us this means that as long as an animal can activate the p21 gene, this can have an overriding affect on suppressing tumor formation caused by either loss of other ...

Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics

...has been made in a vacuum or other conditions that suppress solvent-mediated events. It’s no wonder that we could not get reliable results.?/p> Though numerous molecules have been identified as targets for use as nano-scale electronic components such as switches, photoelectric devices and hydrogen generat...

Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine

... the first evidence of plague vaccines that do not suppress innate immune responses ?and that may be useful for plague vaccination in animals, and, perhaps, humans." The next steps include testing in other animal models, said Schneewind. The two papers combined, Schneewind suggested, are a good example of ho...

Unraveling a stomach cancer puzzle

...trated that by lowering Stat3 hyperactivity we can suppress stomach cancer formation, importantly without affecting Stat3's other important roles in the body. Add to that the evidence suggesting that Stat3 is also involved in breast, head and neck, and prostate cancers, and we have a compelling case for inves...

Improving the potential of cancer vaccines

... off the function of a special group of T cells to suppress immune response to tumors and even infectious dise... (Treg for short). These cells have the ability to suppress the body's natural immune response. If they are depleted, autoimmune diseases will result because th...

Study shows how retinoic acid enters a cell's nucleus

...ABP-II, gets into the nucleus, where it can act to suppress tumors." CRABP-II is a member of a group of prote...ools and knowledge, she hopes to figure out how to suppress the ability of this protein to move to the nucleus and promote cancer, perhaps by blocking the hormo...

Multi-species genome comparison sheds new light on evolutionary processes, cancer mutations

...igger cancer and/or inactivate genes that normally suppress cancer. However, they emphasize that far more work remains to be done to clarify the relationship between cancer and the breakage hotspots. One thing researchers have determined is that the regions immediately flanking the breakage hotspots contain m...

Elevated temperature enhances success of viral cancer therapy

... not advocate the use of pharmacological agents to suppress fever would favor the tumor-selective replication of ONYX-015. This study indicates that induction of a heat shock response by pharmacological agents (that could potentially be administered systemically) or local hyperthermia, could greatly augment a...

Monkeying around to improve organ transplantation

... first time that anergic T cells generated ex vivo suppress renal allograft rejection in non-human primates. This may be an approach that could be used in human transplant trials. Title: Renal allograft rejection is prevented by adoptive transfer of anergic T cells in non-human primates ...

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