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Tag: "suicide" at biology news

Researchers devise new technique for creating human stem cells

...ith chemicals or radiation would induce the cell's suicide program, called apoptosis, he said. Melton emphasized that "at this at this stage in our understanding, the hard fact is that the only way to create an embryonic stem cell from a somatic cell is by nuclear transfer into oocytes. Taking advantage of ...

Malfunctioning bone marrow cells sabotage nerve cells in diabetes

...subvert the purposes of nerve cells "almost like a suicide bomb," said Chan. Diabetes mellitus, which afflicts roughly 18 million Americans, is a major health problem that affects multiple organs and tissues. Diabetes can be treated. However, treatment does not ward off many of the complications. Neuropath...

Duke Experiments Boost Radiation's Cancer-Killing Effects

...ancer cells in dying by a process of self-directed suicide called 'apoptosis,'" said Dewhirst. "If HIF-1 is inhibited prior to radiation, it will make the cell less sensitive to apoptosis and will thereby make the tumor cells more resistant to radiation." Moreover, because radiation itself boosts HIF-1 leve...

IBM Transforms the Art of Scientific Expeditions

...ancer cells in dying by a process of self-directed suicide called 'apoptosis,'" said Dewhirst. "If HIF-1 is inhibited prior to radiation, it will make the cell less sensitive to apoptosis and will thereby make the tumor cells more resistant to radiation." Moreover, because radiation itself boosts HIF-1 leve...

Enzyme inhibitors block replication of SARS virus

...zotriazole esters are relatively stable and act as suicide inhibitors," Wong said. "They block the enzyme, are transformed through a co-valent bond, and are unable to get out." Wong said the findings published today provide better insight into the mode of action of the enzyme, which may lead to development ...

Hooked on fishing, and we're heading for the bottom, says scientist

... of fish stocks. "The industry is ready to commit suicide at any time," he says. "It's an industry that needs to be reined in for its own good." He notes that the global fisheries industry is very complex. According to Dr. Pauly, it operates with "one foot deep in illegality," by landing illegal catches, a...

Study finds drug may cut down involuntary movements

...in Huntington's disease, and one subject committed suicide during the study. Patients will also need close supervision so that suicide can be prevented." ...

Suicide risk does not increase when adults start using antidepressants, study finds

The risk of serious suicide attempts or death by suicide generally decreases in the weeks after patients start taking antidepressant medication, according to...

New HIV study identifies high-risk subgroups of adolescents

...hol and drug use, school problems, delinquency and suicide attempts. However, this is one of the first studie...h problems, such as psychiatric hospitalization or suicide attempts, than other study participants. By contrast, amongst the girls, two distinct profiles emerg...

New lab technique churns out fungus' potential cancer fighter

...ave, the chemical tricks certain cancer cells into suicide while leaving healthy cells untouched. "In 2000, scientists in Japan discovered that this compound might have some tremendous potential as a prototype anticancer agent, but no one has been able to study or develop it because it's so hard to get enou...

New lab technique churns out fungus' potential cancer fighter

...ave, the chemical tricks certain cancer cells into suicide while leaving healthy cells untouched. "In 2000, scientists in Japan discovered that this compound might have some tremendous potential as a prototype anticancer agent, but no one has been able to study or develop it because it's so hard to get enou...

Mechanism identified for promising neurological drug

...ecause it damages cells," Swanson notes. "And cell suicide is not necessarily the best thing for the whole organism." Is he being understated? The second observation, Swanson says, was made a decade ago by study co-author Tiina M. Kauppinen, PhD, currently a neurology research fellow at SFVAMC and UCSF, whe...

Fatty spheres loaded with siRNA shrink ovarian cancer tumors in preclinical trial

...when combined with chemotherapy. By inducing cell suicide (apoptosis) among blood vessel cells, the treatmen...ge of proliferating tumor cells and increased cell suicide among cancer cells. Sood and Professor of Molecular Therapeutics Gabriel Lopez-Berestein, M.D....

Interfering RNA silences genes in 'slippery' immune cells

...ation to HIV treatment. "The siRNA may represent a suicide vector: by knocking down HALP it may allow HIV-infected cells to self-destruct, thus eliminating a hiding place for the virus," said Dr. Finkel. "More broadly," she added, "the technique could theoretically be directed against other immune-related...

Scientists work to identify genes that contribute to early heart attack risk

...e, ages 15 to 34, who died from accidental causes, suicide and homicide. This study, which started in 1985, provided some of the best evidence that the process of atherosclerosis begins in childhood and adolescence. Using the latest technology, scientists will screen tissue samples from the study looking for...

A new understanding of how cells defend themselves against bacterial pore-forming toxins

...e cells, for example, may be better off committing suicide if their membranes are penetrated, because they could become deadly if their function is compromised. Van der Goot adds that a better understanding of the biochemical pathway that allows epithelial cells to survive an invasion by a pore-forming to...

PNAS study reveals why organs fail following massive trauma

... stop expanding into an army (anergy) or to commit suicide (apoptosis). The PNAS study offers new evidence that an overwhelming wave of biochemical signals created by the innate response after massive trauma can mistakenly trigger anergy and apoptosis, especially in T cell lymphocytes, shutting down the ad...

Molecular 'signature' protects cells from viruses

...ecific killer cells. They also initiate the cell's suicide programme ?apoptosis. The viruses cannot then cont...re' stimulate an immune reaction and initiate cell suicide opens up completely new perspectives for the therapy of virus infections and cancer cases: for examp...

Antibiotic inhibits cancer gene activity

...uced cancer cells, but not normal cells, to commit suicide in a process called apoptosis. The new screening technique, Gartel said, gives researchers a rapid way to find agents that target oncogenes -- genes believed to cause cancer. He said siomycin A, the first compound found with the method, "is particu...

Turning a cellular sentinel into a cancer killer

...e "guardian of the genome" because it triggers the suicide of cells with damaged DNA. Inactivation of p53 can set the stage for the development of different types of cancer. The researchers' findings show for the first time that inactivating the p53 gene is necessary for maintaining tumors. While the resear...

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