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Tag: "suggests" at biology news

UCLA launches $20 million stem cell institute to investigate HIV, cancer and neurological disorders

...htly linked," Gasson said. "More and more evidence suggests that cancer is a stem cell disease. Many of our current therapies are not effective because they don't target the cancer stem cells. Our experience with gene medicine and the GMP facilities will make it easier for us to translate our basic stem cell ...

Norovirus, AIDS vaccine and Hepatitis Virus

...oV infection among TD cases examined in this study suggests that further investigations concerning the role of these viruses in TD are warranted." (A.R. Chapin, C.M. Carpenter, W.C. Dudley, L.C. Gibson, R. Pratdesaba, O. Torres, D. Sanchez, J. Belkind-Gerson, I. Nyquist, A. Karnell, B. Gustafsson, J.L. Halpe...

Fleshing out the genome

...nergy research institution in Richland, Wash., now suggests a way to put this house in order. They offer a powerful new method that integrates experimental and computational analyses to ascribe function to genes that had been termed "hypothetical" -- sequences that appear in the genome but whose biological pu...

Discovery Promises Simpler Therapy for Sickle Cell Disease

...r treating the disease, they said. Their research suggests that an inability of red blood cells to relax blood vessels through the release of nitric oxide is a major factor behind the disease's primary symptoms -- including oxygen deprivation and blocked vessels that can lead to pain, clots and stroke. Thus,...

Nanoscale Diagnostic Sets Sights on Alzheimer's

...rs in blood. Research by Klein and his colleagues suggests that ADDLs first appear in the earliest stages of Alzheimer's. If the BCA process can identify the markers before symptoms develop, doctors may be able to combat the illness in its nascent form when treatments may be most effective. In the first ste...

Insight into natural cholesterol control suggests novel cholesterol-lowering therapy

...ich cells limit cholesterol synthesis. The finding suggests a novel approach to the development of cholesterol-lowering drugs that may boost the effect of statins, one of the most prescribed cholesterol inhibitors, according to researchers at the University of Texas Southwestern Medical Center. Cells obtain ...

A human parasite with a streamlined mitochondrion

...me but might not perform other functions. The work suggests that the Entamoeba mitosome may represent the simplest mitochondrion yet described, and thus it provides a model system for probing which mitochondrial functions are truly essential for eukaryotic cells. ...

Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection

...w" disease and Creutzfeld-Jakob disease in humans, suggests that the ability of prions in one species to infec...ril issue of the journal Cell. Although research suggests that prions from one species rarely infect other species, some scientists believe the species barrie...

Increased risk of osteoporosis associated with gene that one in five people have

...ffected by genetic variation in CYP1A1. "Our study suggests that this genetic variant specifically affects the hip bones," Villareal says. "For those with this form of the CYP1A1 gene, that's not good news. Low density in the hip can lead to hip fractures, which can be devastating." Recent statistics from th...

HIV-1 spread through six transmission lines in the UK

...e UK can be traced back to one source, a new study suggests that HIV spread via at least six independent virus...llay of UCL's Centre for Virology says: “Our study suggests that the HIV-1 subtype B epidemic currently circulating the UK is made up of at least six establishe...

Light therapy may combat fungal infections, new evidence suggests

...the human pathogen Cryptococcus neoformans further suggests that light therapy, in combination with anti-fungal drug treatments, might offer an effective method to combat a variety of fungal infections, particularly those of the skin or nails, said HHMI investigator Joseph Heitman, M.D., James B. Duke profess...

Heart repair gets new muscle

...very from a heart attack. However, recent evidence suggests that the heart might harbor stem cells after all and that such cells can be transformed into cardiomyocytes. In a new study published in the premier open-access online journal PLoS Biology, Neal Epstein and colleagues report that a special group of ...

Computational Method Speeds Mapping of Cell Signaling Networks

...ect indirect influences" between molecules. Pe'er suggests a similar technique could be used to study the differences between normal and abnormal cells. This application would be particularly useful for understanding disease states where signaling malfunction plays a prominent role, including cancer and auto...

Researchers find new genes necessary to make embryo

...e are associated with tumors. The C. elegans study suggests specific cellular roles for these genes, thus providing important clues to how these genes work in humans. The new data also asked allowed the researchers to have a first genome-wide look at a classic genetic phenomenon called "partial penetrance" ?...

Researchers rein in regulatory RNAs

...gative and enriched in the nucleus, which strongly suggests a functional role for these transcripts in gene re...plants. "Conventional belief in molecular biology suggests that poly(A)+ mRNAs are major mediators in flows of genetic information," Abe explains. "However, th...

Reservoirs may accelerate the spread of invasive aquatic species, researchers say

...s the fluctuating resource availability hypothesis suggests that these characteristics will enhance the susceptibility of reservoirs to invasion. Because reservoirs are more saline that freshwater lakes, Havel, Lee, and Vander Zanden propose they could provide a haven that helps invaders from saline and brack...

Harmful chemicals may reprogram gene response to estrogen

...most DES-exposed women did not develop the cancers suggests that genetic predisposition is an important part of the equation. "In most cases, we already have tests that can determine if a woman has a genetic predisposition for cancer," said Walker. This is not the first study to suggest that cancer risk is i...

Scientists identify genetic pathways essential to RNA interference

...DNA damage pathways, which was totally unexpected, suggests a potential connection between RNAi and the control of cell division in cancer." The researchers note that better understanding the mechanisms underlying RNAi could help transform what has been a research tool into a powerful therapeutic tool. Altho...

White Blood Cell 'Waste Disposal' System Plays Critical Regulatory Role

...esearch, published in the March issue of Immunity, suggests that the process for disposal of dying neutrophils...ils. "The discovery of neutrophil-regulating cells suggests new ways to manipulate the inflammatory system and neutrophil production with possible relevance to ...

Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells

...earchers at St. Jude Children's Research Hospital, suggests a way to improve the outcome of children who receive treatment for acute lymphoblastic leukemia (ALL) or other blood cancers. Results of the St. Jude study are published in the current online issue of Blood. The researchers demonstrated how to over...

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