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Tag: "suggested" at biology news

Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

... protect the integrity of the genome. Studies have suggested that deficiency in cells' capacity for DNA repair contributes to the accumulation of DNA damage and accelerates the genetic changes involved in carcinogenesis. To evaluate whether reduced DNA repair capacity in the nucleotide excision pathway that f...

Growth in the sea comes down to a struggle for iron

...sorb carbon dioxide, a powerful greenhouse gas, he suggested that natural increases in iron inputs to the oceans during the geologic past may have removed enough carbon from the atmosphere to affect global climate, perhaps even contributing to the onset of ice ages. Martin died in 1993 just as tests of his ide...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

....In addition to using human serum, the researchers suggested thepossibility of using what are called "feeder ce... the Nature Medicine paper, notingthat none of the suggested approaches guarantees the completeelimination of Neu5Gc from existing cultures. "Therefore, it would...

Newly discovered virus linked to childhood lung disorders and Kawasaki disease

...n by the newlyidentified New Haven coronavirus was suggested by findings in the Yalegroup's second study, which was initiated when they found evidence ofthe virus's genetic structure in respiratory secretions from an infantwith classic signs of Kawasaki disease. In addition to heart disease,the signs can inclu...

Novel Therapy Tested in Mice Could Chase Away Cat Allergies

... cultures with GFD,?says Dr. Saxon. “Those results suggested that GFD successfully prevented the immune cells from reacting to cat allergen. The next step was to test GFD in mice that we had made allergic to the allergenic protein found in cat saliva and dander.?/p> The researchers tested GFD in two differ...

New Clues Add 40,000 Years to Age of Human Species

... radiometric dating methods were less accurate and suggested an age of roughly 130,000 years. No one was able to securely tie both sets of fossils to the same time period. "Fortunately, small pumice fragments from two sediment layers were perfect for precise isotopic dating," says McDougall. “The pumice cl...

Enzyme shown to help protect genomic stability

...the aging process. Some studies, for example, have suggested that low-calorie diets that extend life also boost Sir2 activity dramatically. ...

Discovery of key protein's shape could lead to improved bacterial pneumonia vaccine

...fullaboratory tools. Previous work by another team suggested that CbpAbinds to pIgR. However, that finding was made in “test-tube?experiments without using actual bacteria. So the St. Jude teamdeveloped pneumococcus bacteria that had mutated CbpA in order to provethat live bacteria with mutated CbpA could not ...

New comparative toxicogenomics database

...fullaboratory tools. Previous work by another team suggested that CbpAbinds to pIgR. However, that finding was made in “test-tube?experiments without using actual bacteria. So the St. Jude teamdeveloped pneumococcus bacteria that had mutated CbpA in order to provethat live bacteria with mutated CbpA could not ...

Tiny scaffolding allows stem cells to become working fat cells

...ld develop type II diabetes," Kniss said. He also suggested that the new approach might have commercial applications as a way of testing new drugs. "Small, three-dimensional cell colonies could be grown on multi-well assay plates and be used to test dozens of compounds at the same time," he explained. "Since...

UCSD discovery may help extend life of natural pesticide

...us findings with the roundworm C. elegans strongly suggested that specific sugar structures are likely critical for Bt toxin susceptibility," said Joel Griffitts, the first author on the paper and a former graduate student with UCSD biology professor Raffi Aroian. "This latest paper demonstrates what these sug...

Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits

...ding. Such networks enriched for several functions suggested to the researchers that cellular processes may work together in a coordinated fashion. In contrast, the team did not find in yeast a network they found in both worm and fly that is involved in the guidance of nerve cell axons to their synaptic targe...

VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain

...the mechanisms of alcoholism." Other studies have suggested that interfering with Bdnf signaling can alter alcohol consumption. If researchers can identify drugs that may inhibit or activate the function of one of the genes identified in these studies, they may be able to generate new treatments for alcoholi...

Rats infected as newborns grew up vulnerable to memory problems during an immune challenge

...olecules, in response to germs. Prior research had suggested that higher IL-1BETA in the brain's hippocampus, a key memory area, disrupts the consolidation of memories following a learning experience. Thus it appears that there may be an optimal range for IL-1BETA, with either too much or too little inhibiting...

World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics

...tocol before returning to Japan. Dr. Shapiro first suggested the idea of starting a living donor islet transplant program in Kyoto while lecturing there three years ago. Cadaveric organ donors are scarce in Japan, and living donation has very established roots in liver and kidney transplantation there. "Livin...

HIV vaccine trial breaks ground for future research

...he high-risk and the non-white groups. The authors suggested two plausible explanations, one for each group. Those with high-risk behavior may have been exposed frequently to HIV and a primed immune response, probably cellular or humoral, could have worked with the vaccine and caused a greater ability to resis...

Discovery Promises Simpler Therapy for Sickle Cell Disease

...ong with oxygen and carbon dioxide. Those findings suggested that nitric oxide defects might play a role in the cardiovascular side effects of many disorders, including diabetes, heart attacks, septic shock and sickle cell disease. In the current study, the researchers found that hemoglobin in the red cells o...

Low level of extinction during ice age linked to adaptability

... was amplified by the presence of glaciers. "I've suggested that those brachiopods which eventually became extinct had adapted only to small temperature changes, and thus did not survive," he said. "The other competing hypothesis is that large fluctuations of sea level, driven by the melting and reforming of ...

Stem cells from brain transformed to produce insulin at Stanford

...e, in fact, neurons. Taken together, this evidence suggested to Kim that neural stem cells may be able to produce insulin. Despite Kim's informed hunch, the fact that it worked is a bit surprising. Until recently, people had though that stem cells taken from the brain would only be able to transform into bra...

Increased risk of osteoporosis associated with gene that one in five people have

...f Bone and Mineral Diseases. "The link to estrogen suggested that the gene could also affect bone density. No one had ever investigated that possibility, so we set up a study to evaluate the relation between bone density and variations of the CYP1A1 gene." The researchers studied 156 women with an average age...

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