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Tag: "substrate" at biology news

Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy

...nd identify non-muscle tropomyosin as an important substrate of the enzyme's activity," Rockman said. "The findings may offer a new approach to the treatment of heart failure." Drugs that selectively prevent PI(3)K from activating tropomyosin -- either by modifying tropomyosin or inhibiting PI(3)K's enzymatic...

Gene Bridges And Covalys To Develop Restriction-Enzyme-Free SNAP-tag Gene Fusion Kits

...s, which will contain validated reference BAC, and substrate for functional testing of the SNAP-tag in the fusion protein, are expected to be on the market in Q3/2005. The cloning kits will be developed and distributed by Gene Bridges, and the labeling kits for SNAP-tag fusion proteins as well as SNAP-tag cDNA...

Microreactor efficiently regenerates cofactors for biocatalysis

...odel biocatalytic process by converting an achiral substrate (pyruvate) into a chiral product (L-lactate), using lactate dehydrogenase as the enzyme. While further research is needed to improve the performance of individual microreactors, the present work shifts the emphasis from the longstanding problem of c...

Scientists find microRNAs regulate plant development

...are ~22 nucleotide long RNA molecules that provide substrate specificity to a protein complex known as the RNA-induced silencing complex. Within the complex, microRNAs are thought to bind to mRNA molecules containing a complementary stretch of RNA sequence. The complex then cleaves the mRNA into smaller pieces...

Motor transport in bio-nano systems

...ystem consists of filaments which are aligned on a substrate surface as shown in Figure 1. The filaments are po...artments, which resemble large cells adhering to a substrate surface. Surprisingly, the geometry of the system has a rather strong effect on the build-up of tra...

Could microbes solve Russia's chemical weapons conundrum?

...ransformation by the microbial cells when a growth substrate (MEA/EG) is present. However as the cells did not grow in the presence of PHT alone, the authors conclude that the bacteria cannot use them for growth. The group hopes that the bacterial strain can be used in the context of plant-microbial associa-t...

Brain-injury rehabilitation depends on acetylcholine circuitry

...basal forebrain cholinergic system as an essential substrate in mediating cortical plasticity and functional recovery following focal cortical injury." They also concluded that drugs that inhibit breakdown of acetylcholine or those that encourage brain wiring growth "may enhance cortical plasticity and improv...

LUCA technologies confirms real-time methane generation

...nity of microorganisms ("microbial consortium") in substrate samples taken from the 110,000 acre Monument Butte...o-labeled CO2 (carbon dioxide) introduced to these substrate samples is converted to radio-labeled methane. This demonstrates that the methane formation is the r...

Mayo Clinic Researchers Create 'Obedient Virus'; First Step To Use Measles Virus Against Cancer

...row retargeted measles virus on special "universal substrate cells" -- while at the same time conserving the viral component for targeting and destroying tumors. Mass production of a retargeted virus was not possible before this specific innovation of the molecular tag -- and research in this area was at an im...

Open microfluidic and nanofluidic systems

...eory addresses the strong capillary forces between substrate material and liquid and takes the ‘freedomâ€TM o...he channel width; and (ii) the interaction between substrate material and liquid. One has to distinguish seven different liquid morphologies which involve locali...

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