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Genes In The Interferon System Important In Systemic Lupus Erythematosus

... Professor LarsRönnblom. "Itis remarkable that by studying only eleven of the some 200 genes thatare seen as belonging to the interferon system, we were able toidentify two genes with such clear connection to SLE," says ProfessorAnn-Christine Syvänen.A few years ago Lars Rönnblom and Professor Gunnar Alm at ...

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...which had been tied to colon cancer by researchers studying families with excessive growths, or polyps, in the colon. Mice with extra IGF2 and the APC mutation developed twice the number of tumors as mice with the mutation but whose IGF2 levels were normal. The tumors grew at the same rate in both sets of mi...

Growth in the sea comes down to a struggle for iron

... scientists from UMaine and other universities are studying the fate of iron in marine waters. Their findings ...d." Many scientists from around the world are now studying iron effects in these regions. Though scientific efforts are aimed primarily at understanding these ...

Fox Chase Cancer Center scientists identify immune-system mutation

..., SCID mice have become a highly valuable tool for studying the immune system and are now used by scientists worldwide. Kappes' co-authors on the new Nature paper include Fox Chase postdoctoral associates Xiao He, Ph.D., Xi He, Ph.D., and Vibhuti P. Dave, Ph.D., (who is now at the Institute of Clinical Resea...

Whole genome fine map of rice completed

...e genome sequences will lay a solid foundation for studying the differences among strains of rice and shed insight into mechanisms of hybrid advantages at a new level, according to BIG researchers. The efficiency and data quality of the fine maps of two strains of rice, Indica and Japonica, are better than t...

“Nano-scissors?laser shows precise surgical capability

....“This tool opens up a new frontier for biologists studying nerveregeneration,?says Ben-Yakar. “We can also apply it to many otherstudies that require nanosurgery, so it’s a very versatile tool.?The beauty of this laser, she says, is its ability to cut organelles(parts of cells—they are what organs are to org...

The transparent organism: EMBLEM and Carl Zeiss give labs a unique look at life

...PIM. "Molecular biology has graduated upwards from studying single molecules - now we need to watch complex, three-dimensional processes in whole, living organisms. SPIM allows us to do that with unprecedented quality." In a series of technical innovations, Stelzer and his colleagues (in particular Jim Swoge...

Scientists seek answers on what activates deadly anthrax spores

...ego. The research stems from lessons learned from studying the bacteria that cause Staphylococcus infections and two other bacteria in the same group as anthrax. Claiborne said the group proposes that a vitamin B5 derivative known as Coenzyme A plays a crucial role in the germination of the anthrax spores. ...

The secret lives of whales

...ncide with shifts in food distribution. Now, he is studying reactions of whales to sound pollution, tracking how whales move away or go quiet as human activities enter an area. Every decade the amount of noise is doubling. “Whales have very traditional feeding grounds and their migratory routes along coastlin...

Antibiotic Resistant Bacterium Uses Sonar-like Strategy to “See?Enemies or Prey

...cal School. Gilmore and his team have spent years studying the bacterium known asEnterococcus faecalis, one of the leading causes of hospital-acquiredinfections, to find new ways to treat them. These infections arefrequently resistant to many, and sometimes all, antibiotics. Tens ofthousands of deaths due to...

Researchers reveal the infectious impact of salmon farms on wild salmon

...earchers isolated the effect of the salmon farm by studying the infection levels of migrating juvenile pink and chum salmon as they approached and passed a salmon farm. Within the study area, the salmon farms are anchored in a long thin fjord. Here the wild salmon have no choice but to pass by the farm on the...

Mouse brain tumors mimic those in human genetic disorder

...me features as those seenin children with NF1, and studying those tumors has helped usunderstand the cellular events involved in NF1 brain tumordevelopment," says principal investigator David H. Gutmann, M.D.,Ph.D., the Donald O. Schnuck Family Professor of Neurology.The study appears online and will be publi...

Spider Venom Could Yield Eco-Friendly Insecticides

...are toxic to insects, but not vertebrates. King is studying the molecular structures of the toxins that selectively target the nervous systems of insects to understand the toxins' mechanism of action at the cellular level. Because these toxins do not affect the mammalian nervous system, it may be possible to ...

Purdue proves concept of using nano-materials for drug discovery

...e. "You can think of it as a micro-petri dish for studying biochemical reactions," Lee said. The alumina contains pores smaller than 100 nanometers, and the total volume of the reactors varies from 1-10 nanoliters. "What's unique about this device is that the surface has nanometer-scale pores in it," Lee s...

Scientists discover the cellular roots of graying hair

...ratinocytes with theperson’s characteristic hue.By studying mice at progressively older intervals, Fisher and hiscolleagues discovered that as the rodents aged and their hair beganturning gray, the numbers of stem cells diminished in proportion to theloss of color. The scientists were surprised to observe tha...

Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery

...ratinocytes with theperson’s characteristic hue.By studying mice at progressively older intervals, Fisher and hiscolleagues discovered that as the rodents aged and their hair beganturning gray, the numbers of stem cells diminished in proportion to theloss of color. The scientists were surprised to observe tha...

Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.

...ratinocytes with theperson’s characteristic hue.By studying mice at progressively older intervals, Fisher and hiscolleagues discovered that as the rodents aged and their hair beganturning gray, the numbers of stem cells diminished in proportion to theloss of color. The scientists were surprised to observe tha...

Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease

...s. Technological breakthrough Bernstein has been studying chromosome wrappings for five years as a postdocto...ot seen before by using standard techniques, or by studying one gene at a time. "Finding them was a complete surprise," Bernstein admits. HOX genes, as noted, ...

First 'atlas' of key brain genes could speed research on cancer, neurological diseases

...e brain pinned down.The map should tell scientists studying different parts of the brain,which transcription factor (TF) genes regulate the development of thatbrain region, and which of them to investigate as possible causes ofbrain tumors and other diseases.The Dana-Farber researchers already have homed in o...

U-M scientists find genes that control growth of common skin cancer

...s areconsistent with previous work from other labs studying differentHh-associated tumors, “but we were very surprised to see that sometumor cells persisted after shutting down Gli2 expression,?saidDlugosz.In some of the regressed tumors Gli2 reactivation leads to resumptionof BCC tumor growth, suggesting tha...

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