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Tag: "structure" at biology news

Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin

...pokes of a bicycle tire," Therien said. "When this structure absorbs light, it gives rise to an intense, localized fluorescence signal that is uniquely suited for visualizing living biological systems." According to Therein, there is keen interest in developing new technology that will enable optical imaging ...

Kinovate Life Sciences Launches Nittophase?High Performance Solid Support For Oligonucleatide Synthesis

...igonucleotide industry. Solid support is the base structure used in the synthesis of oligonucleotides, including diagnostic probes and primers, antisense including RNAi, microRNA, DNA-based and aptamer drugs and represents a substantial portion of the cost to manufacture these oligonucleotides. NittoPhase?ha...

Institute for Systems Biology Symposium Addresses Need for Better Computational Tools

..., outlining current efforts to run Rosetta de novo structure prediction on World Community Grid, and applicatio...n function in over 60 complete genomes via de novo structure prediction. Other presenters included keynote speaker Dr. Nathan Myhrvold, Founder of Intellectual V...

Gene therapy promising for growing tooth-supporting bone

...anting a new one---the patient also needs the bone structure to anchor the new tooth in place. Such reconstructive surgery today involves either taking a bone graft from the patient's chin or jaw, which leaves a second wound needing to heal, or using donated bone from a tissue bank, which yields unpredictable ...

Alzheimer's cognitive decline slowed

...lled the nucleus basalis, and in the cerebellum, a structure associated with cortical plasticity. In addition to Tuszynski, authors of the paper in Nature Medicine, were Leon Thal, M.D., UCSD chair of neurosciences, director of the UCSD Shiley-Marcos Alzheimer's Disease Research Center (ADRC), and a neurologi...

Researchers make gains in understanding antibiotic resistance

...hrough crystals of proteins. The underlying atomic structure of the proteins is deduced by analyzing the patter...t MLSBK antibiotics. The researchers analyzed the structure of erythromycin ?among the most widely prescribed macrolide antibiotics ?bound to a mutated version ...

Revolutionary nanotechnology illuminates brain cells at work

...e common bacterium E. coli. We first predicted the structure of this protein, and then placed the two fluorophores at specific positions on the binding protein," commented co-author Loren Looger. "After fusion to the fluorescent proteins, we placed the sensor on the surface of rat hippocampal cells. The hippoc...

Potential Drug Target For Treating Cocaine Abuse Found

...ances that bind to them may depend on the chemical structure of those substances," says NIDA's Amy Newman, who synthesized the compound. The researchers found that their novel drug made contact with transporters slowly ?about 10 times slower than cocaine ?which, they speculate, may be why it does not have a st...

PET/CT can identify new cancer lesions at early stage, allowing for prompt treatment

...t that generates a detailed view of the anatomy or structure of organs and tissues in the body. Combining PET with CT provides images showing function (PET) and anatomy (CT) and a merged or "fused" picture of the body's metabolism and structure. ...

Global analysis of membrane proteins

...ination of experimental techniques and theoretical structure prediction methods to produce simple structural models for some 600 membrane proteins from Escherichia coli. They have also identified those membrane proteins that the bacterium can manufacture in large amounts, and those that it has difficulties to ...

Biochemists report discovery of structure of major piece of telomerase; implications for cancer

... biochemists have determined the three-dimensional structure of a major domain of telomerase, the enzyme that h... the first major piece of telomerase for which the structure is known. Telomerase plays a key role in most cancers, and this work ultimately may lead to targets ...

NYU and MSKCC research provides model for understanding chemically induced cancer initiation

...is single methyl group, it assumes an intercalated structure in which the carcinogenic residue is sandwiched between adjacent base pairs in the double helix. "Such conformational differences in methylated and unmethylated DNA sequences may be significant because of potential alterations in the cellular proces...

Marine sponge yields nanoscale secrets

...ss or cotton. This primitive skeleton supports the structure of the sponge, and we've discovered how this glass is made biologically." The newly reported research describes an important step forward in translating nature's production methods in the biological world into practical methods for the development o...

Protein Discovery Could Unlock The Secret To Better TB Treatment

.... Scientists believe that uncovering the molecular structure of this protein will lead the way to designing dru... Molecular Biology, a combined team discovered the structure of a protein known as resuscitation promoting factor (Rpf). Five versions of the Rpf protein exist i...

After a time-shift, mixed signals from the circadian clock

...are controlled by the central clock within a brain structure known as the suprachiasmatic nucleus (SCN). The clock is synchronized to environmental cycles of light and dark. It is well known, from everyday experience, that adjusting to new light schedules takes several days, though the details of how this adap...

The lopsided brain: Attention bias is shared by humans and birds

...sing, given that birds lack a corpus collosum, the structure in human brains that is thought to facilitate rapid communication between the two hemispheres. In the past, such communication via the corpus collosum has been thought to form the basis for asymmetries in human spatial attention, but the new observat...

Supercomputers to focus brains on AIDS dilemma

...m traditional x-ray crystallography studies of the structure of a complex between the HIV-1 integrase catalytic domain and an inhibitor pointed to the existence of only one site where inhibitors could bind. These studies indicated a single format for small inhibitors of integrase to bind at the catalytic site,...

Basis for DNA ejection from single phage particles

...enome is packaged during morphogenesis, and a tail structure that ensures the attachment of the phage to the host bacteria. A common feature of phages is that during infection, only their genome is transferred to the bacterial host's cytoplasm, whereas the capsid and tail remain bound to the cell surface. This...

Conserved amino acids play both structural and mechanistic roles in sandwich-like protein

... sandwich-like proteins are there to stabilize the structure or to speed up the protein-folding process is best...a group of proteins that fold into a sandwich-like structure consisting of two sheets of amino acids meshed together. Nearly 70 superfamilies of proteins of vary...

Mouse with designer liver has enhanced glucose tolerance, insulin response

...ecently discovered protein called Gab1. Gab1 has a structure that is similar to other proteins in a family known as Insulin Receptor-Signaling, or IRS, proteins. IRS proteins relay signals initiated by insulin receptors and thus play a critical role in insulin regulation inside cells. Biochemical studies on Ga...

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