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Tag: "striking" at biology news

'Smart' genetic therapy helps the body to heal itself

...he development of neurodegenerative symptoms. This striking prevention of the disease lasted during the whole 2 year life span of the mouse. "Knowing that a class of drug called histone deacetilase (HDAC) inhibitors was able to stimulate the expression of ALDR in the mouse and in human cell lines, we became...

Ghost protein leaves fresh tracks in the cell

...ir test animal because its genetic makeup has many striking similarities to humans. "In our study, we showed spectrin doesn't have to bind to ankyrin to do its job," said Dubreuil. "This hints at a complexity we never had any idea about in trying to understand how these molecules work." Dubreuil and his c...

Gut reaction: Researchers define the colon's genome

...microbe M. smithii . These known organisms showed striking similarity to much of the microbiome residents. Based on the sequence comparisons, the researchers conclude that the human GI tract hosts multiple strains of B. longum , and a majority of its archaeal species is related M. smithii. How many uniqu...

Fragmentation rapidly erodes Amazonian biodiversity

...arly 32,000 Amazonian trees since 1980. The most striking finding, say the authors, is the remarkable speed at which tree communities are changing in forest fragments. “Rainforest trees can live for centuries, even millennia,?said Laurance, “so none of us expected things to change too fast. But in jus...

Insulin receptor stops progression of Alzheimer's disease

...s of the brain, with PPAR delta producing the most striking effect in preserving the hypothalamus and temporal lobes, areas of the brain responsible for memory, learning, and behavior. In these brain regions, PPAR alpha and PPAR gamma were effective in reducing amyloid gene expression. PPAR delta had the most...

Buildup of damaged DNA in cells drives aging

...look for other similarities. What they found was a striking similarity pattern between the progeroid and normal-aged mice in several key pathways. Indeed, for genes that influence the growth hormone pathway, there was a greater than 95 percent correlation in changes in gene expression between the DNA repai...

Asia's odd-ball antelope gets collared

...he shoulder and weighing about 50 pounds, the most striking feature of the saiga is its large nose, or proboscis, similar to a tapir. The function of this unusual nose is not clear, but it may serve to warm or filter air during Mongolia's frigid winters and notorious dust storms. Today saiga numbers have ...

Cellular traffic backups implicated in skeletal malformations

...er, hatched and survived to nine days, albeit with striking skeletal abnormalities ?craniofacial defects, kinked fins and shortened body. The pathway affected by the crusher mutation is key to transporting proteins outside of the cell. All proteins are made in the endoplasmic reticulum (ER), a labyrinthine ...

Uniform tungsten trimers stand and deliver

...into fuels and value-added chemicals. "There is a striking difference between commercial catalysts and the new model system," said Mike White, the UT professor leading the PNNL Institute for Interfacial Catalysis. Variability in commercial catalyst size and chemical composition makes it difficult to accurate...

Air travel and flu: Post-9/11 restrictions delayed start of season

...omestic air travelers was lower. However, the most striking finding was that the peak date of the US flu season following September 11, 2001 was delayed, by 13 days, to March 2. Following the terrorist attack, there were restrictions on air travel and many people themselves chose to use other forms of transpo...

Regulating the nuclear architecture of the cell

...architecture is in its early stages." The most striking feature of any nucleus is its chromosomes. These are made of chromatin, which combines DNA with a set of proteins known as histones; four similar histones join together to form a cylindrical spool around which the DNA wraps. Each of these bundles is ...

Proteins necessary for brain development found to be critical for long-term memory

... Department of Neurobiology and Behavior. "It is a striking example of how molecular rules employed in building a brain are often reused for different purposes throughout a lifetime." The researchers have shown that proteins known as growth factors are as essential for the induction of long-term memory as t...

Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese

...e where there were major differences. "We made a striking observation," says Sinclair. "Resveratrol opposed the effects of high caloric intake in 144 out of 153 significantly altered pathways. In terms of gene expression and pathway comparison, the resveratrol fed group was more similar to the standard di...

Vitamin D deficiency widespread during pregnancy

...d lead author of the study. "The numbers also were striking for their newborns ?92.4 percent of African-American babies and 66.1 percent of white infants were found to have insufficient vitamin D at birth." A vitamin closely associated with bone health, vitamin D deficiency early in life is associated with...

Scientists reveal structure of gateways to gene control

...periodic rotation of the DNA double helix. "It is striking how well these positions match with the architecture of the DNA as it wraps around the nucleosome's protein core," Pugh said. This result powerfully simplifies previous theories about the possible architecture of gene packaging. "There is a certa...

Scientists discover new species of distinctive cloud-forest rodent

...an ancestors. The newly discovered species casts a striking new light on the evolution of an entire group of arboreal rodents." ...

Viral protein is an effective preventative against infection

...se bacteria take advantage of a viral infection by striking when our resistance is lowered," says Fischetti, head of Rockefeller’s Laboratory of Bacterial Pathogenesis and Immunology. "You should start taking an antibiotic the moment you come down with the viral infection to prevent the secondary infection, b...

Cracking open the black box of autoimmune disease

...rticularly strong affinity. "This relation was striking because Ptpn22 is strongly associated with type 1 diabetes, rheumatoid arthritis, lupus and Graves' disease, but the gene had not been previously linked to regulatory T-cell function," says Alexander Marson, a MD/PhD student in the Young lab and lead...

Biologists produce global map of plant biodiversity

... general understanding among ecologists about this striking difference continues to be very limited. "Given that we are far off from knowing the individual distributions of the world's 300,000 odd plant species," says Jetz. "Holger Kreft and I investigated how well the richness of plants can be predicted f...

Scientists unlock mystery of embryonic stem cell signaling pathway

...nd that’s our goal.?"Kahn's study provides us with striking new insights into the molecular regulatory machinery inside embryonic stem cells,?adds Martin Pera, Ph.D., director of the Center for Stem Cell and Regenerative Medicine at the Keck School of Medicine. “His team has identified a chemical that control...

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