Mosaic mouse technique offers a powerful new tool to study diseases and genetics
...l, researchers from Stanford University describe a streamlined method for creating a "genetic mosaic mouse"--a rodent whose body is genetically engineered to produce small clusters of cells with mutated genes. The new technique, called Mosaic Analysis with Double Markers (MADM), was developed in the laboratory ...Microbe has huge role in ocean life, carbon cycle
...dy outlines how SAR11 has one of the most compact, streamlined genomes ever discovered, with only 1.3 million base pairs ?the smallest ever found in a free living organism and a number that's literally tiny compared to something like the human genome. "SAR11 has almost no wasted DNA," Giovannoni said. "This org...NIAID researchers show how promising TB drug works
...hony S. Fauci, M.D. "This new finding will allow a streamlined approach for making improved versions of the drug." "Previously, we were flying blind in trying to optimize PA-824 in a rational way because we didn't know which M. tb protein was the target of PA-824's action," says NIAID scientist Clifton Barry,...Sleeping sickness parasite shows how cells divide their insides
...Sickness. Like many parasites, it is exceptionally streamlined and has only one of each internal organelle, making it ideal for studying processes of more complex organisms that have many copies in each cell. When thinking about how cells divide, doubling and separating DNA in chromosomes is often the focus. E...Despite their heft, many dinosaurs had surprisingly tiny genomes
...omparative Zoology. "In fact, our work shows these streamlined genomes arose long before the first birds and flight, and can be added to the list of dinosaur traits previously thought to be found only in modern birds, including feathers, pulmonary innovations, and parental care and nesting." Other researchers......ifferences far exceeds the expectations for such a streamlined genome, as the scientists write in this week’s edition of Science magazine. Arabidopsis plants from different geographical origins differ in many traits (the background shows schematically sequence variation in the DNA of these plants). To track...