Genome study of beneficial microbe may help boost plant health
...plant pathologists around the world have used this strain as a laboratory model to study beneficial microbes. Paulsen says the P. fluorescens project also pioneered a new methodology. This novel approach relies on the analysis of repeated regions of the DNA sequence to help identify segments of the genome ...UN pours polio vaccine into Yemen amid outbreak
...paigns are implemented rapidly. While these events strain the financial resources of the global eradication effort, they do not threaten its ultimate success," UNICEF said. The Global Polio Eradication Initiative, formed by WHO, UNICEF, Rotary International and the US Centers for Disease Control and Preven...Specialized immune-system B cells play double-barreled role
...ences of too many or too few B-1a cells. Also, the strain lacking CD19, and therefore B-1a cells, enabled the researchers to isolate sufficient numbers of pure B-1b cells for study. The researchers studied how the immune systems of the two mouse strains reacted to infection with Streptococcus pneumoniae, t...Scientists reveal how disease bacterium survives inside immune system cell
...response to A. phagocytophilum with that of a weak strain of S. aureus. Using microarray technology that allowed them to compare about 14,000 different human genes, the researchers discovered how the response to A. phagocytophilum deviates from that of S. aureus, and thus permits the HGA agent to survive. ...Enlisting genomics to understand flu evolution
...ment event from a persistently cocirculating minor strain to a previously dominant strain leading to an epidemiologically significant outcome--the emergence of the "Fujian" strain in the 200...International Team Determines Geographic Origin of Leprosy
...to characterize at a molecular level the M. leprae strain infecting a leprosy patient, which will show whether the patient has a new infection or if the previous infection was incompletely treated and has returned. This, in turn, will aid efforts to fully treat patients so that the bacteria are completely e...Researchers develop new method for facile identification of proteins in bacterial cells
...ested their technique using Sphingomonas wittichii strain RW1, the only bacterium known to consume the backbone of toxic polychlorinated dibenzo-p-dioxins and dibenzofurans as a food source. The researchers already knew that feeding dioxins to RW1 would cause an increased enzyme level as the bacterium consu...Novel plague virulence factor identified
... infecting the worm. "We thought that a Y. pestis strain (known as KIM5) that lacks the genes (hmsHFRS oper...o protect humans from the plague." Since the KIM5 strain of Y. pestis is well characterized and has a lower biosafety ranking than other infectious or toxic ...New Look at DNA Hints at Origin of UV Damage
... infecting the worm. "We thought that a Y. pestis strain (known as KIM5) that lacks the genes (hmsHFRS oper...o protect humans from the plague." Since the KIM5 strain of Y. pestis is well characterized and has a lower biosafety ranking than other infectious or toxic ...Scientists find that protein controls aging by controlling insulin
...hs. For the current study, they created a second strain of mutant mice in which the Klotho gene generated more of the protein than in normal mice. Those mice lived between 19 percent to 31 percent longer than normal mice. The researchers were especially interested in how the hormone affected insulin, be...Fragment of yellow fever virus may hold key to safer vaccine
.... Then they screened the libraries with a vaccine strain of yellow fever. Four of the antibodies neutralize...side effects from variations of the weakened virus strain now grown in fertilized chicken eggs. ...VCU study shows hormone-like molecule kills cells that cause inflammation in allergic disease
...ce, the mast cells died. Furthermore, a separate strain of mice with the same mutation as the first strain, but that had also been engineered to prevent IFNγ production, were found to have almost as many mast cells as normal mice, if not more. They concluded that the presence of high IFNγ levels...Climate model links higher temperatures to prehistoric extinction
...ce, the mast cells died. Furthermore, a separate strain of mice with the same mutation as the first strain, but that had also been engineered to prevent IFNγ production, were found to have almost as many mast cells as normal mice, if not more. They concluded that the presence of high IFNγ levels...Researchers uncover E. coli's defense mechanism
...om the John Innes Centre, studied a non-pathogenic strain of Escherichia coli, which is very closely related to Salmonella bacteria. The pathogenic forms of E. coli and Salmonella are usually transmitted to humans through undercooked meat, unwashed vegetables and cross contamination from surfaces on which ...Beyond genes: Lipid helps cell wall protein fold into proper shape
...by the specific proteins associated with it. In a strain of E. coli lacking PE, the GabP protein misfolded, with two areas of the protein inverting from their normal structure. The PE-lacking protein's amino acid transfer rate plummeted to nearly zero, falling 99 percent compared to the transfer rate in un...Boosting The BCG Vaccine To Beat Tuberculosis
...immunogenicity of BCG and describe a novel vaccine strain with high efficacy against tuberculosis. The researchers engineer a BCG strain that secretes the listeriolysin protein, which punches holes in the membranes of phagosomes where M....Researchers Discover Ancient Origins Of Tuberculosis-causing Bacteria
...immunogenicity of BCG and describe a novel vaccine strain with high efficacy against tuberculosis. The researchers engineer a BCG strain that secretes the listeriolysin protein, which punches holes in the membranes of phagosomes where M.......immunogenicity of BCG and describe a novel vaccine strain with high efficacy against tuberculosis. The researchers engineer a BCG strain that secretes the listeriolysin protein, which punches holes in the membranes of phagosomes where M....Elderly mice yield clues to the process of growing old
Delving deep into the molecular subtleties of a strain of mice engineered to age rapidly, scientists have found that an accumulation of genetic mutations prompts a cascade of programmed cell death that seems to underpin the aging process. Writing today (July 15, 2005) in the journal Science, a team of s......he production of bulk quantities of a non-virulent strain of anthrax, and for equipment to produce significa...y and be willing to grow Bacillus anthracis Sterne strain at 1500-litre quantities." Other contracts are for fermentation equipment for producing 3000-litre b...