Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection
... contact with hamster prion amyloid fibrils, a new strain of mouse fibrils emerged with the ability to infect hamsters but not humans. The new mouse strain had the same amino acid sequence as the original mouse strain but completely different infectious ca...HIV-1 spread through six transmission lines in the UK
...alysed the epidemic history of the HIV-1 subtype B strain from sampled gene sequence data. Molecular data on HIV-1 has become increasingly available since the introduction of routine HIV-1 gene sequencing for drug resistance. Scientists used this data to follow the changing number of infected individuals th...Marburg haemorrhagic fever in Angola update
...wn mortality rates ranging, according to the virus strain involved, from 53% to 88%. The only other large outbreak of Marburg, in the Democratic Republic of Congo from 1998 through 2000, had a case fatality of 83%. Two factors make the rapid detection of outbreaks of Marburg haemorrhagic fever difficult: t...Harmful chemicals may reprogram gene response to estrogen
...ncer as an adult." The researchers used a special strain of rats with a defect in a gene called Tsc-2 (tuberous sclerosis complex 2) that made them more susceptible to uterine leiomyomas, benign tumors that are common in women over 30 years of age. These rats were then treated with DES during days 3, 4 and...Scientists identify genetic pathways essential to RNA interference
...thor John Kim, PhD, and his colleagues developed a strain of C. elegans into which they added a gene that caused the worms to glow under ultraviolet light but also turned that gene off using RNAi. They then used RNAi to inactivate every one of the worms' 19,000 genes by feeding the worms bacteria that produ...Yeast Network Prevents Damage By Oxygen Radicals
...tions and gross chromosomal rearrangements in each strain were then analysed to identify genes that cooperate to prevent the deleterious effects of ROS and promote normal cell survival. "These results suggest that endogenous ROS-induced genome instability may contribute to cancer progression," says Dr. Kol...Same-Sex Mating Discovered in a Toxic Fungus
...cribed mating strategy might allow a single mating strain to expand rapidly by cell division, yet retain its ability to generate diversity by undergoing sex, said Heitman. That diversity might provide an advantage when faced with new environmental challenges, he said. While the findings have no immediately...Turning viruses into allies against cancer
...rvival from this disease. "The attenuated vaccine strain of measles virus is an oncolytic virus which has shown anti-tumor activity and tumor-selectivity in a variety of different tumor models," said Blechacz. "But its potential in primary liver tumors has never been evaluated." In the first part of their...Roots Engage in Underground Chemical Warfare
... of the tested strains of bacteria. One particular strain of Pseudomonas syringae, a bacterium that causes disease in both tomatoes and Arabidopsis, has a seemingly fail-safe mechanism to overcome the plant's defenses. The bacterium not only survives exposure to the antimicrobial substances, it also blocks ...Could microbes solve Russia's chemical weapons conundrum?
...em for growth. The group hopes that the bacterial strain can be used in the context of plant-microbial associa-tions to create a new generation of biotechnologies for remediation of soils contaminated by CWAs or products of their detoxification. "Bioutilization of organic compounds of reaction masses is a...Secret of smallpox's success may lead to bioterror cure
...have already been exposed to a particularly lethal strain of vaccinia, or to mouse pox, another pox virus. "We want to look at all of our mutants and see which ones work best in this post-exposure prophylaxis," explained Jacobs. Though results are preliminary, several strains look promising. Jacobs' exper...AIDS Public Awareness Campaign Expands Following Report Of Rapidly Progressive HIV
...t reports of a drug-resistant, rapidly progressive strain of HIV in New York City, we must continue to reinf...lth and Mental Hygiene reported a highly resistant strain of rapidly progressive HIV diagnosed in a New York City resident. The patient is a male in his mid-4...Sugar beet virus mutation requires Texas touch
...ush's program was reinvigorated in 2002 when a new strain of beet necrotic yellow vein virus emerged. The new strain threatened sugar beet production in California and Minnesota. Getting answers was important because ...Chemical Engineer Kao Explores Antibiotic Synthesis With DNA Chips
...see how it works. For Kao, it means asking how one strain of Saccharopolyspora erythraea produces ten times the erythromycin of normal strains. The answer, it seems, lies not in the cluster of genes known to produce the antibiotic, but in a mutation of another gene that co-regulates the timing of expressio...Scientists identify genes responsible for 'black rot' disease in vegetables
...he authors sequenced the complete genome of an Xcc strain that was isolated from an infected cauliflower plant in England during the 1950's. They then compared this sequence to a previously published sequence from a cabbage-derived Xcc strain. Although the gene content of the two strains was very similar, t...Active Vaccine Prevents Mice From Developing Prion Disease
...pie prions were attached to a genetically modified strain of Salmonella. This bacterium is also used in several animal vaccines and in human vaccines for cholera and typhoid fever. Among mice vaccinated prior to prion exposure, approximately 30% remained alive and symptom-free for 500 days, according to the...Fungus Effective Against Winged Termites
...anean Termite Research Unit--have discovered a new strain of the fungus Metarhizium anisopliae that is highl... colonies. Raina stumbled across the novel fungal strain after capturing dozens of swarming alates for other studies. To his surprise, all of the insects die...15 generations of untrained jocks, couch potatoes show big physiological adaptations
...s wondered what would happen if they took a single strain of rats ?meaning they all had the same basic genetic background ?and bred two separate lines purely on the basis of "continued selecting of untrained rats with either high- and low-running endurance." In this way, they could study the genetic role in...New miniaturised chip dramatically reduces time taken for DNA analysis
...educe information about the bacteria such as which strain caused the foodborne illness. This type of analysis already takes place in laboratories, but until now the experimental measures needed were not suitable for in situ analysis. By using the new sensors developed by UAB scientists, the time taken to i...