Picking apart how neurons learn
...archers have used mouse mutants to define critical steps involved in learning basic motor skills. The study...s on the behavior of two proteins and the specific steps they take to control a neuron's ability to learn by adapting to signals from other nerve cells. Th...Genetic study shows humans have pushed orangutans to the brink of extinction
...nough genetic diversity to stabilize, if immediate steps are taken to reconnect remnant forest patches and halt further deforestation." ...UCLA scientists find male gene in brain area targeted by Parkinson's
...half in a week. "Initially, the rat could walk 14 steps in 10 seconds," he noted. "After we lowered the SR...vels in its brain, the rat could only manage seven steps in the same amount of time." Vilain believes that variations in SRY levels may be linked to the ons...Junk DNA may not be so junky after all
...Basic Biomedical Sciences. The researchers' next steps are further study of the RET enhancers they found to identify other mutations that might contribute to Hirschsprung disease and MEN2, and to entice other investigators to collectively build a database of human enhancers. "If there's one thing we've ...Infused spleen cells found not to impact islet recovery and reversal of type 1 diabetes in mice
...Basic Biomedical Sciences. The researchers' next steps are further study of the RET enhancers they found to identify other mutations that might contribute to Hirschsprung disease and MEN2, and to entice other investigators to collectively build a database of human enhancers. "If there's one thing we've ...Scientists design potent anthrax toxin inhibitor
...e inhibitor is bound tightly to PA, the subsequent steps of enzyme entry cannot occur and the toxin is effectively neutralized. The investigators tested the anthrax inhibitor in rats. When given in relatively small doses, injection of the inhibitor at the same time as anthrax toxin prevented five out of ...The evolution of food plants: Genetic control of grass flower architecture
...think that ra2 is critical for shaping the initial steps of inflorescence architecture in the grass family, because the ra2 expression pattern is conserved in other grasses including rice, barley, and sorghum". Perspective : Branching Out: The ramosa Pathway and the Evolution of Grass Inflorescence Morph...Less antibiotic use in food animals leads to less drug resistance in people, study shows
...fluoroquinolones in clinical settings," seem to be steps in the right direction toward curbing harmful foodborne bacterial drug resistance. ...Insects that produce males from unfertilized eggs reveal a surprising cellular feat
...l behavior of Hymenopteran insects. One of the key steps in the evolution of social insects, therefore, may have been the development of a mechanism for making centrosomes from scratch. "The Hymenoptera were probably derived from a species that had accessory nuclei, and in the evolution of haplodiploidy t...Researchers now able to look deep into heart to view triggers of a heart's beat
...l behavior of Hymenopteran insects. One of the key steps in the evolution of social insects, therefore, may have been the development of a mechanism for making centrosomes from scratch. "The Hymenoptera were probably derived from a species that had accessory nuclei, and in the evolution of haplodiploidy t...Research details how a virus hijacks cell signals to cause infection
...Children's Hospital of Philadelphia. "We found new steps in the virus life cycle." Dr. Bergelson's study, ..., added Dr. Bergelson, his investigations revealed steps in a virus's life cycle that were previously unknown. "Eventually this understanding may yield clini...Report finds cruise industry is protecting the precious places it visits
...ples of how these stakeholders are taking tangible steps to ensure a sustainable future for cruise tourism, while maintaining the natural and cultural integrity of cruise destinations. "As cruise lines expand their ports-of-call, it is important to not only identify the environmental challenges facing the...The giant protein titin helps build muscles
...s, and for many years we've been investigating the steps by which they are formed," says Matthias Wilmanns, Head of the EMBL Hamburg Outstation. "That probably starts when proteins link up to each other in very big assemblies. The meeting point is the Z-disk, but unraveling the connections has been difficu...Scientists re-engineer a well-known antibiotic to counter drug resistance
...n resistance but a total of 24 sequential chemical steps to prepare the new antibiotics; in this case, a single atom in vancomycin was altered to counter an analogous single atom change in the bacterial cell wall that accounts for the resistance. The results, Boger added, suggest that no matter how the V...Creation of antibiotic in test tube holds promise for better antibiotics
...nk said. "Synthetic chemists in the past needed 67 steps to make it, while nature uses just two enzymes. One of these is the cyclase whose activity we have demonstrated in this paper." The thioether rings vary in size from four to seven amino acids and provide sturdy protease-resistant bonds at precise lo...Study: Paramedics save more lives when they don't follow the rules
...e new approach, first responders skipped the first steps of the standard protocol: intubating the patient for ventilation and delivering a shock using a defibrillator. While still attaching the victim to a defibrillator, they did not wait for the device to analyze the patient's heart rhythm, but started fa...Most human-chimp differences due to gene regulation ?not genes
...n gene expression over evolutionary time. The next steps are to look at larger arrays of genes and to focus on other tissue types. ...A step forward in the fight against bacterial infections
...e mechanism behind this insensitivity. One of the steps in the process of inflammation following contact with LPS is a profuse production of type 1 interferons. These proteins play an important role in the regulation of immunity. The Ghent researchers administered 10 times the lethal dose of LPS to the mu...Mutation in blood stem cells provides clues to cancer development
...; it develops by a series of mutations." The next steps are to see how other stem cell functions on this pathway ?such as self-renewal, survival and proliferation, are affected ?and to duplicate this in-vitro research in mouse models. Working with specific inhibitors developed by local pharmaceutical com...Radiotherapy advance points way to noninvasive brain cancer treatment
...nd cost to an MRI machine. De Stasio says the next steps will include animal and possibly human clinical trials. "If we do see that we can cure animals from their cancers, then it's worth investigating the molecular biology of this drug and seeing what the uptake mechanism is," she says. "But first, you ...