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Tag: "steps" at biology news

Pair of cancer genes found to drive both cell migration and division

...use the new mechanism to divide as well. The next steps are to study the roles of the two genes in dividing cells by seeing if controlling the location of the PTEN and PI3K proteins can determine the direction in which cells divide, Devreotes says. ...

Researchers Closer To Helping Hearing-Impaired Using Stem Cells

... Indiana University School of Medicine are several steps closer to the day when a profoundly deaf patient’s own bone marrow cells could be used to let him or her hear the world. The IU group, led by Eri Hashino, Ph.D., was able to transform, in the laboratory, stem cells taken from adult bone marrow into ...

15 generations of untrained jocks, couch potatoes show big physiological adaptations

...re exciting because "they clearly demonstrate that steps in the oxygen delivery system are coordinated to m... time, optimized in animals," Kirkton noted. Next steps and implications for human attitudes and therapies Having demonstrated the genetic role in enduranc...

High fidelity keeps human DNA assembly line humming

... the NTP bases preload to the DNA template several steps before they are added to the growing RNA chain. This idea contradicts the prevalent view of how RNA and NTP bases hook up. Preloading of NTPs hints at a previously unknown quality control station to maintain accuracy of RNA synthesis. If an NTP does...

Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine

...nation in animals, and, perhaps, humans." The next steps include testing in other animal models, said Schneewind. The two papers combined, Schneewind suggested, are a good example of how, in this era of heightened awareness, "we can use modern tools to learn new things about an ancient scourge, and to pre...

Immune system's distress signal tells bacteria when to strike back

...rdy and colleagues were able to pinpoint key early steps of this lethal process. The transformation starts ...ur goal," Alverdy said, "is to understand the many steps in this process and use that knowledge to find novel ways to intervene, to stop the infection before...

The making and breaking of microtubules

...to capture GMPCPP-bound tubulin during the initial steps of microtubule growth. At low temperatures, GMPCPP-bound tubulin forms curved ribbons of a few protofilaments side by side; as they grow wider the ribbons close into very large helical tubes with a diameter of 500 angstroms, instead of the slim, 25-...

Researchers extend mouse lifespan by protecting against free radicals

...n that they most clearly demonstrate the important steps and pathways in the aging process, Rabinovitch said. By identifying these steps and pathways, scientists could pave the way for future development of drugs or other treatments that...

Molecular steps involved in the creation of gene-silencing microRNAs identified

...icroprocessor complex, which controls the earliest steps in the creation of miRNAs in the cell nucleus. Now, in a new study published online by Nature today, the Wistar group has identified a three-protein complex that picks up the process in the cell cytoplasm and carries it through to the maturation of ...

Motor transport in bio-nano systems

...imeric proteins with two legs, which make discrete steps along the filament. Each step corresponds to a mot...its legs. In one second, the motor makes about 100 steps which leads to a velocity of about one micrometer per second. The absolute value of this velocity is...

Scripps research scientists identify infertility molecule

...he uterus. Problems can occur in any one of these steps along the way and cause infertility. A man might not produce enough sperm, or his sperm might be unable to reach the eggs. A woman might have problems producing eggs or her fallopian tubes may be blocked. Infertility becomes more pronounced for matu...

Scripps research scientists solve structure of a critical innate immune system protein

... work, the structure may also help scientists take steps toward improving human health, since TLRs are implicated in a number of diseases and, hence, constitute potential therapeutic targets. Innate Immunity and Toll-Like Receptors Humans, like all other organisms, are constantly challenged in a world fi...

A protein in the eye may prevent immune response and protect eyes from disease

...exclusive. According to Stein-Streilein, the next steps for the group will be to tease out exactly how the protein accomplishes its goal. Ultimately knowledge of the F4/80 protein and its role in immune regulation may lead to novel therapies for autoimmune diseases of the eye and the body. ...

Researchers develop new method for facile identification of proteins in bacterial cells

...e avoids elaborate conventional sample preparation steps by coaxing the cells into mass production of the protein the researchers wish to analyze. "Finding a specific target in a mixture of hundreds of proteins can be likened to finding the proverbial needle in the haystack; this task can be performed muc...

Scientists discover that three molecules may be developed into new Alzheimer's drugs

...ves a complicated, interwoven series of regulatory steps of genes and proteins "talking" to each other, he explained. "When the conversation goes awry the disease process begins. And it is not just one gene or one protein causing the damage." The complexity of Alzheimer's means that several different medi...

Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels

...ves a complicated, interwoven series of regulatory steps of genes and proteins "talking" to each other, he explained. "When the conversation goes awry the disease process begins. And it is not just one gene or one protein causing the damage." The complexity of Alzheimer's means that several different medi...

Scientists find that protein controls aging by controlling insulin

...ue of Science. "It could be one of the significant steps for developing anti-aging therapy." Dr. Kuro-o and his colleagues originally discovered the Klotho gene in 1997, naming it after one of the mythical Greek fates who controlled the length of human life. Their previous studies have shown that mutant m...

Gene therapy advance treats hemophilia in mouse models

.... "It's an exciting finding, but we are still many steps away from a possible gene therapy for people with hemophilia," he said. Hemophilia A is the leading sex-linked bleeding disorder, affecting one in 5,000 to 10,000 males. People with the condition have a genetic mutation that leaves them with little ...

Carnegie Mellon University research reveals how cells process large genes

...iple recursive splicing steps," Lopez said. "These steps involve the sequential excision of smaller subfrag...uitfly introns, with up to seven potential cutting steps identified for a single intron. Similar analyses suggest that the same process also occurs in large ...

Reversal of role for a viral protein associated with the development of lymphoma

...iple recursive splicing steps," Lopez said. "These steps involve the sequential excision of smaller subfrag...uitfly introns, with up to seven potential cutting steps identified for a single intron. Similar analyses suggest that the same process also occurs in large ...

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