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Tag: "steps" at biology news

DNA Molecules Used To Assemble Nanoparticles

... to five different cells, it would be 25 synthesis steps the traditional way," Baker said. At two to three months per synthesis, and a significant loss of yield for each step, that approach just wouldn't be practical. Instead, the Baker group will create a library of single-functional dendrimers that can ...

Spleen may be source of versatile stem cells

...ese cells. In mammals,Hox11 is a controller of key steps in embryonic development - includingthe formation of the spleen - but it was not known to be present inadults under normal circumstances. In some other animals, however, theprotein has an intriguing function: when creatures like newtsregenerate a los...

Elusive HIV shape change revealed; Key clue to how virus infects cells

... enough to get an answer." One of the lab's first steps will be to determine which shape of gp120 ?bound to the CD4 receptor, or unbound ?is recognized by a person's antibodies. gp120's shape change is an important "escape mechanism" for HIV, allowing the virus to bind to and enter a cell before the immun...

Timing is everything: First step in protein building revealed

...s.Their results support the idea that two separate steps take place oncethe instruction's starting point is found: first a structural change inthe ribosome complex, and then release of eIF1.Lorsch's goal is know the five "Ws" and one "H" that affect timing ofall of the ribosome's pieces and activities. But...

Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible

...This was notsurprising, as RNA required the fewest steps of preparation, whiletissues required the most. The between-lab correlation values decreasedslightly for all samples, but in all cases expression profiles ofsimilar samples could be accurately grouped together.The researchers also examined variations...

Computers to be used to find blueprint for new influenza drug

...If we are successful, we will have taken important steps in finding a new way of fighting influenza and other diseases. It will then be for the pharmaceutical companies to take our blueprint and turn it into a drug.?/p> Professor Williams said that his work is a more sophisticated development from simi...

The secret lives of whales

...de, the world will have taken heed, and instituted steps to reduce the entry of contaminants to the oceans. ...

Vital step in cellular migration described by UCSD medical researchers

...leading only to forward movement. One of the first steps in cell migration is the initiation of activity by Rac that extends protrusions out of the cell. These protrusions serve as tractor sites for migration as the cell moves toward its intended target. If Rac were active throughout the cell, it would ext...

Scientists identify genetic pathways essential to RNA interference

...lf, including the repair of DNA damage. "These new steps indicate there is more to RNAi than RNA destruction," says Kim. "And the connection to DNA damage pathways, which was totally unexpected, suggests a potential connection between RNAi and the control of cell division in cancer." The researchers note ...

Jumping gene helps explain immune system's abilities

...ies that bindto particular antigens, but the early steps of that process have beendifficult to study. Hermes should help reveal some secrets of thisprocess, the researchers say."The immune system takes an approach to protein building similar tothat of diners creating a meal at a cafeteria, but how the immu...

UCSD Discovery Shows How Embryonic Stem Cells Perform 'Quality Control' Inspections

...ies that bindto particular antigens, but the early steps of that process have beendifficult to study. Hermes should help reveal some secrets of thisprocess, the researchers say."The immune system takes an approach to protein building similar tothat of diners creating a meal at a cafeteria, but how the immu...

New therapy for HIV/AIDS eliminates needles and excessive toxicity

...ies that bindto particular antigens, but the early steps of that process have beendifficult to study. Hermes should help reveal some secrets of thisprocess, the researchers say."The immune system takes an approach to protein building similar tothat of diners creating a meal at a cafeteria, but how the immu...

Gene sequencing explains bioremediation 'bug'

...ies that bindto particular antigens, but the early steps of that process have beendifficult to study. Hermes should help reveal some secrets of thisprocess, the researchers say."The immune system takes an approach to protein building similar tothat of diners creating a meal at a cafeteria, but how the immu...

The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures

...rge scale, it would be unthinkable to do all these steps by hand,?said John Norvell, Ph.D., director of the PSI at NIGMS and a scientist trained in protein structure determination. He noted that some robotics and automated tools have been refined and are now marketed by companies for general structural bio...

Newly Discovered Compound Blocks Known Cancer-Causing Protein

...said, and intends to shepherd it through the first steps of drug development by testing the compound in animal models of cancer. The research was supported by grant from the NIH and a Howard Hughes Medical Institute predoctoral fellowship to Casey graduate student Ann M. Winter-Vann, the first author of t...

UCSD team discovers specialized, rare heart stem cells in newborns

...m noted in the Nature paper that the next research steps with the isl1+ cells will be cellular transplantation in living animals to study their role in endogenous repair after cardiac injury. ...

Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses

... rapidly, due to the number of handling and review steps required to insure that the release of that tumor sample in no way jeopardizes patient care. Nonetheless, rapid handling is a necessity in order to maintain the integrity of RNA by quickly freezing the portion of tumor released for analysis. Historic...

Artifical cornea lets woman blind 20 years see

...thesis over the years," Dohlman said. "A series of steps have resulted in good long-term retention and stability, as well as good vision, in patients. We will continue to do research and development in this area so that we can make the devices even safer and less expensive in the future." Both Afshari and...

Molecular Motors Cooperate In Moving Cellular Cargo, Study Shows

...e kinesin, we would expect to see a lot of smaller steps as well." The researchers also noted that faster movements occurred with the same step size, but with greater rapidity. When measured outside the cell, kinesin moved about 0.5 microns per second. Inside the cell, the speed increased to 12 microns pe...

Nanoscale Diagnostic Sets Sights on Alzheimer's

...en treatments may be most effective. In the first steps of the BCA process, unique microparticles latch onto the biomarker targets ?in this study, the ADDLs. The particles are magnetic, a property that aids collection at the end of the procedure. Researchers then add a second ingredient that consists of a...

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