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Tag: "statistical" at biology news

Genes In The Interferon System Important In Systemic Lupus Erythematosus

...le genetic analyses and statistics. The geneticand statistical analyses were performed by the doctoral student SnaevarSigurdsson and Professor Ann-Christine Syvänen at the Center forClinical Medical Research at Uppsala University.The study, comprising nearly 2,000 individuals, shows that two genes inthe interfer...

Male circumcision reduces risk of HIV transmission from women to men

...ata from agroup of male Kenyan truckers and, using statistical models, developedinfectivity measures that estimat...theprobability of infection was calculated using a statistical model thatincorporated published data to estimate the rates of HIV infectionamong the three types of...

Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits

... and fly,. The research team completed a rigorous statistical comparative analysis of a total of 14,145 yeast (Saccharomyces cerevisiae), worm (Caenorhabditis elegans), and fly (Drosophila melanogaster) proteins with 38,965 known interactions. Their PathBLAST tool generated a list of similar proteins in the thr...

Affymetrix and Stratagene Announce Strategic Software Alliance

...ssist(R) Lite, which will be offered as a standard statistical analysis solution of Affymetrix gene expression mi...te will enable the application of industry-leading statistical algorithms and generation of standard Affymetrix-format data files and reports. In its first release...

Genrate: a generative model that finds and scores new genes and exons in genomic microarray data

...ression data that we have created, and discuss the statistical significance of the genes found by GenRate. Three of the highest-ranking gene structures found by GenRate, each containing thousands of bases from the genome, are confirmed using RT-PCR experiments. ...

Genetically modified rice in China benefits farmers' health, study finds

... rice they were growing. For example, there was no statistical difference between the farms in terms of size, share of rice in the farm's cropping pattern, or in the farmers' age or education. Pesticide Use The main difference between the farm households was in the level of pesticides they used. The study show...

Use of Insecticides Linked to Lasting Neurological Problems for Farmers

...fects. The large size of this study gives it great statistical power," said Dr. Kamel. The AHS (http://www.aghealth.org/) is designed to investigate the effects of environmental, occupational, dietary, and genetic factors on the health of the agricultural population. The study will provide information that agri...

Gene Signatures Predict Interferon Response For Multiple Sclerosis Patients

...e regulation—at each time point. The authors used statistical analyses to search for gene expression profiles that were associated with patients' therapeutic outcomes. They looked for patterns in analyses of single genes, gene pairs, and gene triplets, and found their model's predictive accuracy increased with ...

Computational Method Speeds Mapping of Cell Signaling Networks

...searchers are generating vast amounts of data. The statistical approach requires no prior knowledge of signaling pathways to uncover molecular relationships. This is a distinct advantage according to Pe'er, who notes, "Unlike classical biochemical approaches where you need to know all of the intermediate players...

Different microarray systems more alike than previously thought

... two-color long oligonucleotide array, with better statistical results in accuracy and precision than the remaining nine labs. However, the other lab using the two-color long oligonucleotide array had the worst overall performance. But with the exception of that one lab, the results among platforms were in gener...

Stanford gut check shows diversity of intestinal ecosystem

...t detect all known types of microbes and borrowing statistical techniques from field ecology and population genetics, Paul Eckburg, MD, a postdoctoral scholar in infectious diseases and geographic medicine, conducted the most extensive study to date surveying the inhabitants of the lower digestive tract. In the ...

Scripps scientists find potential for catastrophic shifts in Pacific ecosystems

...poses wiggles that are best modeled by traditional statistical approaches. "The dynamics are the same during warm... and work we may be able to make modestly accurate statistical forecasts over short time horizons as shown with certain reef fish (Science 1999)." The paper by the...

Improved statistical tools reveal many linked loci

An innovative new statistical method, described in the open-access journal PLoS ...t, such as blood pressure or cell growth. The new statistical method bypasses the previously overwhelming computations needed to puzzle together the myriad elemen...

Researchers develop promising new gene network analysis method

...with a long-used linear model, a correlation-based statistical method is a more reliable way to map complex gene ...,191 possible players in the c-Myc gene network. A statistical team, led by Gastone Castellani, an associate research professor with the Institute for Brain and Ne...

New tool reveals secrets of migrating cells

...ain can't pick out patterns of movement easily, so statistical techniques are needed to identify cells with different patterns of movement. As an immunologist, Robey focuses on the lives of T cells produced in the thymus and distributed via the bloodstream to the lymph nodes, whence they move into the body's ti...

Survival of heart patients on beta-blockers varies greatly with genetic variation

...he low-risk group according to the hazard ratio, a statistical measure of risk. If further research indicates that beta-blockers are ineffective or create a higher risk in patients with certain variations of beta-adrenergic receptor genes, physicians may modify treatment to improve survival in these patients, ac...

Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease

... patients themselves, showed a strong trend toward statistical improvement(p= .06). In addition, fluorodeoxyglucose (FDG)-PET scans at one year revealed that the treated side of the brain exhibited a statistically significant decrease in abnormal metabolism, while the untreated side showed a further increase in...

Naturally occurring asbestos linked to lung cancer

...e reference for ultramafic rock deposits. Finally, statistical adjustments were made for sex, occupational asbestos exposure and age at diagnosis. The researchers found that the risk of developing malignant mesothelioma was directly related to residential proximity to a source of ultramafic rock. Specifically, ...

Immune system has evolved to prevent autoimmune disease

...s analysis falls within a branch of physics called statistical mechanics, which uses a system's physical behavior...g distribution of onset times would lead to weaker statistical correlations, particularly in those cases where the infection persisted the longest," said Deem. "Se...

Human brain is still evolving

...ces between humans and nonhuman primates. By doing statistical analysis on these sequence differences, they could...m sub-Saharan Africa. To produce more informative statistical data on the frequency of haplotype D among population groups, the researchers applied their methods ...

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