Computational model simulates AZT metabolism in mitochondria
...nating DNA synthesis. Samuels added: "We're just starting our work. It is too early to say what the mechanism of mitochondrial toxicity of AZT is. The inhibition of deoxynucleoside metabolism is one possibility. The incorporation of AZT into mitochondrial DNA is another." He added: "The detailed computation...Nutrition a major factor in rise in twin pregnancies
...teady and substantial increase in MZ twinning, but starting from a low base ?much lower than with natural conceptions", said Professor Jansen. "Our study shows for the first time that the increase we've seen coincides with improving culture conditions and that it started before any manipulation of the zona ...BGSU biologist trying to crack microscopic code
... we want to know what the 'words' mean, and we are starting by asking what happens when we mix the 'dialects.' "It's genetic tinker toys," and an area, he adds, in which BGSU doctoral student Kerry Brinkman is "breaking new ground." Larsen and his graduate assistants do their work with E. coli bacteria, w...Global study shows all tobacco bad for the heart
...tion, public-health efforts to prevent people from starting the habit, and promote quitting in current smokers, will have a large impact in prevention of heart attack worldwide." The number of smokers worldwide is currently estimated to be 1.3 billion, of which 82% are in developing countries. However, most...NHGRI announces latest sequencing targets
...fying these genes gives researchers a more precise starting point for understanding molecular pathways and dev...rences in infectivity. Those genes will be logical starting points for developing more effective diagnostic, prevention and treatment approaches to fungal infec...Heart has enough oxygen to survive hypothermia, CPR crucial
...en hypothermic, I want to stress the importance of starting and continuing cardiopulmonary resuscitation (CPR) efforts with all victims of hypothermia," Tveita said. Doctors typically cease CPR efforts in a normothermic patient after 30 minutes. But CPR should continue on hypothermic patients until after they...New light microscope sharpens scientists' focus
... many labs that could do this in a week, and we're starting with nothing." But the two immediately got to work with what they did have ?which turned out to be old optics equipment Hess had saved from their days at Bell Labs, supplemented by the money in their wallets. They dusted off the equipment and set up ...The brain's executive is an 'event planner'
...ticks to move a cursor on a computer screen from a starting point to a goal. Importantly, the researchers required the monkeys to maneuver the cursor within a maze to reach the goal and to perform those maneuvers in a discrete stepwise fashion with pauses in between. This stepwise approach enabled the researc...Himalayan forests disappearing
...ticks to move a cursor on a computer screen from a starting point to a goal. Importantly, the researchers required the monkeys to maneuver the cursor within a maze to reach the goal and to perform those maneuvers in a discrete stepwise fashion with pauses in between. This stepwise approach enabled the researc...Scientists identify protein with a crucial role in cell death
... Parkinson's disease. A noble stranger... This starting assumption brought two top researchers together: Bart De Strooper, who has extensive experience in Alzheimer research and is thus also interested in the causes of Parkinson's disease, and Luca Scorrano, who specializes in the functioning and effect o...New study reveals signaling pathways required for expansion of pancreas stem cells
...m cells," says Sarvetnick. "Our work may provide a starting point toward improving the efficacy of treatments for patients and perhaps the prevention of clinical disease." "It is not known to what extent replacement of insulin-producing cells occurs in the phase of diabetes when these cells are being activel...Researchers appeal for new regulations to save coral reefs from live fish trade
...has spread from Hong Kong at an accelerating pace, starting at 100 km per year from its coast in the 1970s, to reach over 400 km per year in the 1990s. However, the scientists say the strongest argument for balancing international trade and local needs is the social inequity that arises from the export of t...Gardenia fruit compound starting point for diabetes therapy
...bolism. The chemical therefore represents a useful starting point for new diabetes therapies, they said. Such a drug could offer a big advance, the group added, as no currently available therapy for diabetes actually targets the underlying causes of disease in insulin-producing pancreatic beta cells. Insulin...Researchers discover how bacteria sense their environments
...en activates kinases, or enzymes, within the cell, starting a chain reaction that leads to a response, such as changing how the flagella (or tails) spin. This allows the bacterium to move toward or away from what it has sensed. Such a mechanism of amplification allows signals from the receptors to travel hu......s. "Once you know what a behavior is, you have a starting point to see how the brain is actually controlling it," Wyeth says. ...... that each gene has a single promoter and a single starting position. The team found that, while genes that are only turned on in a specific tissue or at a specific point in time use the traditional model of a single start site, genes used in many tissues have a broad distribution of start sites. This new...New angiogenesis finding may help fight cancer growth
...ood vessel, and during angiogenesis, they migrate, starting an extension of the blood-vessel network. When Paul added NK-B to endothelial cells, "They lost the capacity to organize in three dimensions, to form the tubes that are the precursors to new blood vessels," Bresnick says. "Then we got excited." Fu...Amgen introduces comprehensive financial assistance programs for cancer patients
...ncology access program in the industry, and we are starting with Amgen Oncology Assistance. To ensure patients have access to Vectibix, we have priced it at approximately 20 percent less than the other antibody on the market and created the Vectibix Cap, which is the first of its kind for colorectal cancer p...Scientists' cell discovery unearths evolutionary clues
...eir multicellular life style. "This provides a starting point in allowing us to examine what happens at the molecular level as species evolve and mutate," said Professor Schaap, of the Division of Cell and Developmental Biology in the College of Life Sciences at Dundee. "The availability of a family t...AIDS study challenges conventional treatment guidelines for HIV patients
...s in making the decision as to when it is best for starting antiretroviral therapy. Current treatment guideli...istance, often cause doctors and patients to defer starting the medications, until it becomes medically necessary. In addition to the clinical ramifications...