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Tag: "starting" at biology news

Man and mouse share genome structures

..., the mapped tags coincided with the transcription starting points of active genes, as they and others had seen earlier in the yeast. Unexpectedly, they also found tags idling over regions near genes. The researchers think these sites have important regulatory functions, because the methylation patterns are s...

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...the colon's lining had been identified as a likely starting point for tumors, Feinberg and his team tossed a cancer-causing genetic mutation into the mix. The IGF2 mice were crossed with mice carrying a mutation in a gene called APC, which had been tied to colon cancer by researchers studying families with ex...

Columbia research lifts major hurdle to gene therapy for cancer

...ion. Gene therapy, especially forcancer, is really starting to make a comeback."The virus's selectivity for cancer cells is based on two moleculescalled PEA-3 and AP-1 that, the researchers found, are usually abundantinside cancer cells. Both of the molecules flip a switch (called PEG)that turns on the produc...

Timing is everything: First step in protein building revealed

...n yeast'sprotein-building machinery recognizes the starting line for a gene'sinstructions, it first alters its...wo separate steps take place oncethe instruction's starting point is found: first a structural change inthe ribosome complex, and then release of eIF1.Lorsch's ...

Gene variations explain drug dose required to control seizures

...ransporters and drug metabolizing enzymes are good starting points for understanding variation among patients in drug response." In Parkinson's disease, for example, a pharmacogenetic test might assist physicians in prescribing the drug dose that will balance short-term control of tremors with long-term drug...

Ice core 'dipstick' indicates West Antarctic ice has thinned less than believed

... ice streams that were flowing even then, probably starting in about the same places they do now. "If you are making the ice sheet thinner over time, you're also stretching it much farther, so the individual layers get much thinner than they would be in a steady state," Waddington said. Waddington is lead a...

Simple drug has the potential to save many lives threatened by malaria

... to administer outside hospital, so buying time by starting treatment which is easy to administer in the community is crucial. Researchers in Uganda compared the effectiveness and safety of conventional treatment (intravenous quinine) with an alternative treatment (artemether, given as a suppository) in 103 ...

South America's vast pantanal wetland may become next everglades, UNU experts warn

...a's famed Everglades, altered by drainage projects starting in the 1940s to make way for development and agriculture. In a message to mark World Water Day, March 22, UNU says the Pantanal provides enormous environmental services by storing and purifying water, providing storm protection and flood mitigation,...

World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics

... to Japan. Dr. Shapiro first suggested the idea of starting a living donor islet transplant program in Kyoto while lecturing there three years ago. Cadaveric organ donors are scarce in Japan, and living donation has very established roots in liver and kidney transplantation there. "Living donor islet transpl...

Chemists identify immune system mechanism for methamphetamine binges

...ack' of the 21st century," Janda says. "We're just starting to unravel its mechanism of addiction." Further studies of the drug are planned, he adds. Methamphetamine is a powerful psychostimulant that goes by a number of common names, including "speed," "ice" and "crank." It is often made in make-shift labor...

WHO Warns Of Increased Risk Of Vector-borne Diseases In Tsunami-affected Areas

...a stopgap measure. In addition, health workers are starting to involve the community to clean up the Aedes mosquito breeding sites in the open water containers and debris around camps and homes", added Dr Samlee. Experts have been deployed and an Early Warning and surveillance systems has been established in...

miRNA profiling

...odel organism, this analysis provides an important starting point for dissecting of function and evolution of small RNAs and their targets. ...

Defenseless plants arm themselves with metals

...at gene is, so we need to deconstruct the process, starting with things we can measure, which are these visible traits, and then we work backwards." A question that has long stymied Salt and his colleagues centers on the origins of this trait. While essential as micronutrients, metals are toxic in high level...

First technology to remove prions that cause vCJD from blood launched

... are working very closely with health authorities, starting with the nations hardest hit by vCJD, to help protect the safety of the blood supply and prevent the spread of this insidious disease." The new prion reduction filter will be evaluated by the United Kingdom (UK) National Blood Service and the Irish ...

Are rice and wheat behind China's population boom?

...id growth of the earliest cities in northern China starting as far back as 2400 to 2000 BC is the result of successful rice farming combined with other crops, says University of Toronto anthropologist Gary Crawford. Although we often associate rice with Chinese agriculture, most archeologists have, until rec...

Elephant seal pups suffer from ocean warming

...h the ocean temperature generally increased before starting to cool again in 2000. The pups, from a rookery located in central California, were weighed within 10 days of weaning. Le Boeuf and Crocker's results show that the pups' mean weaning weight declined from 146 kg in 1976 to 115 kg in 1999. This coincid...

Gene keeps neural cells on correct developmental path

...said. REST seems to work globally, binding to the starting points of as many as 1,000 genes at once. The gradual loss of REST in differentiating neurons probably orchestrates a precise sequence of genes sensitive to different levels of REST, Mandel speculates. REST has been a difficult gene to study. Using ...

To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists

... and Mutations A few years ago, when he was first starting to think about this, Romesberg encountered a paper in a scientific journal that discussed certain genes that "make mutations," as he put it. When these genes are deleted from cells, the cells lose their ability to mutate, even when subjected to massi...

Future diabetes drugs may target new protein interaction

...h levels of a chemical called pyruvate, which is a starting material for making glucose, and then accumulated high levels of sirtuin1 protein. (Rodgers will receive the Nupur Dinesh Thekdi Research Award on April 14 for this work as part of the School of Medicine's 28th annual Young Investigators' Day celebra...

PHACCS, an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information

...h levels of a chemical called pyruvate, which is a starting material for making glucose, and then accumulated high levels of sirtuin1 protein. (Rodgers will receive the Nupur Dinesh Thekdi Research Award on April 14 for this work as part of the School of Medicine's 28th annual Young Investigators' Day celebra...

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