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It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...both sets of mice, suggesting that more tumors get started in the mice with extra IGF2, notes Feinberg. "In the mice, loss of imprinting of IGF2 roughly doubles the risk that the genetic mutation will cause a tumor," says postdoctoral fellow Atsushi Kaneda, Ph.D. "Double the risk may not seem like much, but...

Plants respond similarly to signals from friends, enemies

...y same bacterial machinery against it." The study started as a graduate research project of Ravisha R. Weerasinghe, the lead author of the paper, in the lab of Dr. Nina Allen, professor of botany and co-author of the paper. Weerasinghe first observed the changes in the plants triggered by signals from rhizo...

Scientists rid stem cell culture of key animal cells

...tart to differentiate within two to three days. Xu started by evaluating the effect of changing stem cell growth conditions - using less feeder cell material, or no serum replacement, for instance. Unexpectedly, Xu found that the presence of serum replacement promoted stem cell differentiation. Digging deep...

Genetically modified natural killer immune cells attack, kill leukemia cells

...er to grow large populations of NK cells, the team started with samples of blood containing a variety of different immune system cells. They placed this sample into a dish containing a type of human leukemia cell called K562. Campana's team genetically modified the K562 cells so they carried on their surface...

Introduced foxes transformed vegetation on Aleutian Islands from lush grasslands to tundra

...e of predators began disappearing when fur traders started introducing foxes onto islands in the Aleutian arc...after the removal of the foxes, the vegetation has started to become lusher again," Byrd said. "The terrestrial ecosystem was probably modified in more ways th...

Development of portable infectious disease detector

...ueeze everythingonto a single chip, Pria designers started with a desktop diagnosticsystem and shrank it down...ation is an example of the power ofserendipity. It started when David Schaffer, a VIIBRE student whostayed on at the institute as a project engineer after he g...

The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures

...The first half of this project ?a pilot phase that started in 2000 ?has centered on developing new tools and processes that enable researchers to quickly, cheaply, and reliably determine the shapes of many proteins found in nature. “One thousand protein structures is a significant milestone for the PSI, and...

Family trees of ancient bacteria reveal evolutionary moves

...always have been," Blank said. "When Cyanobacteria started to appear, there was no ozone shield, so UV light would have killed most things. They either had to have come up with ways to deal with the UV light ?and there is evidence that they made UV-absorbing pigments ?or find ways of growing under sediments ...

Effective Cancer Treatments Follow The Clock

...modulation of the circadian clock. We have already started screening sets of chemical compounds for their ability to affect this function. We are also planning additional studies to discover the molecular signals from the circadian machinery to the immune system that might prove to be useful drug targets.?/p...

Gene Signatures Predict Interferon Response For Multiple Sclerosis Patients

...peripheral blood mononuclear cells. After patients started interferon therapy, blood was taken at specific time points over the course of two years. Baranzini et al. measured the expression level of 70 genes—including a number involved in interferon interactions and immune regulation—at each time point. The...

A frog's life is food for thought

...nown about their digestive physiology when I first started this project and for an animal that can starve for up to four years it is really interesting when you relate that back to human starvation," she said. "There is no way a human could last for four years without food." Green-striped burrowing frogs s...

Polymers with copper show promise for implanted sensors

...ty in San Diego, Calif. "The idea we had, when we started working on this problem about eight years ago, was to try to mimic what occurs in the human body to prevent clotting on the walls of your own blood vessels," said Meyerhoff. "Your endothelial cells---the cells that line all of your blood vessels---ge...

Transgenic plants remove more selenium from polluted soil than wild plants, new tests show

... the transfer of genes through pollen. "Before we started the study, we took aerial surveys to ensure that no other mustard-related plant species were being grown in the vicinity," said Banuelos. He noted that every morning trained workers swept through the fields to literally nip any flowers in the bud, a...

Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells

...er to grow large populations of NK cells, the team started with samples of blood containing a variety of different immune system cells. They placed this sample into a dish containing a type of human leukemia cell called K562. Campana's team genetically modified the K562 cells so they carried on their surface...

New understanding of DNA repair may pave way to cancer treatments

...lance," he said. The Ronai lab's work on ATF2 was started at Mount Sinai School of Medicine in New York City, from which Dr Ronai and his colleagues recently relocated to the Burnham Institute. This study was carried out in collaboration with Wolfgang Breitweiser and Nic Jones of the Paterson Institute for ...

NIH Researchers Discover How Insulin Allows Entry of Glucose Into Cells

...ile leaving the inside of the cell dark. “When we started the experiment, we thought that the vesicles would be stationary,?Dr. Zimmerberg said. “The vesicles looked like comets streaking by.?/p> Dr. Zimmerberg added that studying the chemical steps of the process in which the vesicles fuse with the cel...

Scientists journey to southern Africa to unravel the secret world of elephant communication

...n 1992, the year she began her work at Mushara. "I started doing research on elephants for the Namibian Minis.... "It was a unique collaboration," Hart says. "We started with the physics of it, then moved to behavior and how the animals would respond." Getting geophysi...

Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

...is the Key to Control Ever since biologists first started mapping genetic traits to particular genes, science and society have been fascinated by those tens of thousands of stretches of DNA within the nuclei of cells we call our genes. One thing that has become clear in the last several decades, however, i...

Measuring hormone cuts antibiotic use in half in pneumonia patients

...iotics. The remaining 85% had high levels and were started on antibiotics. The researchers measured their pro...were low. Patients in the procalcitonin group who started on antibiotic treatment were able to stop after an average of six days. Their course of illness was ...

Scientists discover that three overlapping signals in embryo help get the backbone right

...gold found that as the mass of cells in the embryo started to take form, a region in the embryo - what they called the "organizer" - seemed to be the source of signals to nearby cells, telling them to form back structures. What clinched their experiment was taking the organizer from one embryo - in their exp...

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