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Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...xisting cultures. "Therefore, it would seembest to start over again with newly derived human embryonic stem cellsthat have never been exposed to any animal products, and ideally, onlyever exposed to serum from the intended transplant recipient.""However, such an approach could not be pursued under existing...

Elusive HIV shape change revealed; Key clue to how virus infects cells

...s so hard to make an HIV vaccine, and will help us start strategizing about new approaches to vaccine development." The studies, performed in the Children's Hospital Boston Laboratory of Molecular Medicine, used the closely related simian immunodeficiency virus (SIV) as a stand-in for HIV. By aiming an X-...

Timing is everything: First step in protein building revealed

...s, the workhorses of cells. If theribosome doesn't start in the right place along a gene's instructions,it ...afterits release from the complex can the ribosome start making proteins."No one had any idea when eIF1 was released from the ribosome, or thatits release mi...

Scientists Replicate Hepatitis C Virus in Laboratory

...e the correct ends of the HCV genome and to act as start and stop buttons to gene activity. The construct was “naked,?meaning that it contained only nucleic acids, the genetic material of the virus, and did not have the HCV viral envelope, a protective shell of lipids and proteins that surrounds the viral ...

Researchers reveal the infectious impact of salmon farms on wild salmon

...tes, taking measurements every 2 to 4 km. The fish start in the rivers and head to sea, traveling en masse in large mixed schools. Thus the scientists could see the effect on the salmon as they moved toward the farm. They found that the juvenile salmon carried almost no sea lice prior to the farm but becam...

Mouse brain tumors mimic those in human genetic disorder

...stalways occur in children ?these tumors generally start growing inchildren younger than 5 years old and usually do not progress after age10. A similar pattern occurred in the mice: The optic nerve and chiasmwere enlarged and astrocytes along the optic pathway began multiplyingand growing when the animals ...

New imaging method gives early indication if brain cancer therapy is effective, U-M study shows

...brain and mapped the changes in diffusion from the start of therapy to three weeks later. The tumor cells block the flow of water, so as those cells die, water diffusion changes. In the study of 20 people with malignant brain tumors, the researchers found that any change in the functional diffusion map pr...

Scientists rid stem cell culture of key animal cells

...feeder cells because, in their absence, stem cells start to differentiate within two to three days. Xu started by evaluating the effect of changing stem cell growth conditions - using less feeder cell material, or no serum replacement, for instance. Unexpectedly, Xu found that the presence of serum replac...

Development of portable infectious disease detector

...ensive and there is always aquestion about when to start and stop anti-retroviral therapy," saysPria's Chief Technology Officer Jason Pyle. "We are developing a devicethat we hope will allow medical professionals and HIV patients tomanage their disease in a way that is similar to how diabetes patientscan m...

New SARS Protein Linked To Important Cell Doorway

...which can be attained very rapidly, and get a head start on detailed biophysical investigations of emerging diseases months before we can even begin to work with such diseases in culture." Fremont led the initial analysis, which was dedicated to identifying sequences of genetic code that might translate i...

Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimer's, Parkinson's Disease

...ion are not fully understood," he said. "When you start a normal reaction, molecules are free in solution so they interact with each other randomly," Akhremitchev said. "If you want to dissect the process, you would rather want to study interactions individually." Thus, the Duke chemists capture individu...

TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

...ut the ability to commit suicide, these cells will start multiplying entirely out of control. "This is exactly what we saw in mice that were genetically modified so their B lymphocytes were over-expressing MYC," Grosveld said. "When we forced over-expression of TEL2 in these mice, we curtailed apoptosis i...

Family trees of ancient bacteria reveal evolutionary moves

...iomass ?has concluded that these species got their start on Earth in freshwater systems on continents and gradually evolved to exist in brackish water environments, then higher salt ones, marine and hyper saline (salt crust) environments. Cyanobacteria are organisms that gave rise to chloroplasts, the oxy...

Antibiotic might fight HIV-induced neurological problems

...in SIV-infected monkeys, but it is not expected to start until sometime next year. "It is too early to recommend minocycline for patients," emphasizes Ned Sacktor, M.D., an associate professor of neurology at the Johns Hopkins Bayview Medical Center who wasn't involved with the current study, but who is o...

Increased risk of osteoporosis associated with gene that one in five people have

...r for evaluating that risk. "Ideally, you want to start early to avoid osteoporosis," Villareal says. "Our next study will look at a much younger group of women. My guess is that we will find that females with this variant gene are breaking down estrogen rapidly from the day they are born. In that case, t...

WHO Warns Of Increased Risk Of Vector-borne Diseases In Tsunami-affected Areas

...ich generally mostly live and bite outdoors - will start biting indoors more frequently. We have to monitor for these situations and support the communities so they are protected from disease, and have access to treatment when they need it". "To reduce the risk of a dengue fever or malaria cases, WHO is s...

Glow-in-the-dark zebrafish at UH hold keys to biological clocks

...th day of development, about the age when the fish start to swim and feed." The researchers used zebrafish (danio rerio) because they yield such a high output of spawn, with hundreds of eggs being laid by each female per week. This gives the scientists a better chance of identifying mutant fish whose biol...

Revolutionary nanotechnology illuminates brain cells at work

...e second fork close to the first one, it will also start to give you a tone even though they do not touch. This is resonance energy transfer." FRET is used to track the form of proteins that specifically bind metabolites such as sugars and amino acids. A protein of interest is genetically fused with two d...

Researchers report new pro-inflammatory role for anti-inflammatory enzyme

...l endotoxin (part of the bacterial cell wall) they start to produce inducible nitric oxide synthase (iNOS), an enzyme responsible for the manufacture of nitric oxide (NO). This results in an increase in cellular NO which contributes to inflammation and host defense. "NO acts as a cytotoxic/cytostatic effe...

Technique may allow cancer patients to freeze eggs, preserving fertility before starting treatment

...ition, the hormone treatments require delaying the start of cancer therapy, which may not be an option for every patient. Guidelines for patients and physicians still need to be established as the technique begins to be offered in a clinic setting, Smith says. "This is a very new technology and it require...

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