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Tag: "standard" at biology news

Scientists design potent anthrax toxin inhibitor

...sting, they could one day be important adjuncts to standard antibiotic therapy for the treatment of inhalation anthrax," says NIAID Director Anthony S. Fauci, M.D. The spore-forming bacterium Bacillus anthracis produces a toxin that causes anthrax symptoms. Antibiotics are used to treat anthrax, but even wit...

Defective immune system response to smallpox vaccine detailed in new study

...virus, the live virus that is the key component in standard smallpox vaccine. The investigators are part of NIAID's Atopic Dermatitis and Vaccinia Network, which was created in 2004 to integrate clinical and animal research aimed at reducing the risk of eczema vaccinatum, a potentially deadly complication o...

Potential vaccine developed for deadly leishmaniasis disease

...is by adding a booster substance ?an adjuvant. The standard existing adjuvant, alum, has limitations. Potential alternative adjuvants are toxic, expensive or have other problems. Seeberger’s candidate vaccine combines the delivery vehicle, immune-stimulating antigen and adjuvant into one package. The delive...

Ancient DNA provides clues to the evolution of social behavior

...ys. By fitting modern and ancient DNA data into a standard population genetics model, Chan was able to pinpoint the drastic decline of C. sociabilis to about 2,600 years ago, when the population was likely reduced to less than 300 individuals. When a population becomes that small, it loses much of its geneti...

Stem cell study for patients with heart attack damage seeks to regenerate heart muscle

... product is that it is given to patients through a standard IV line. Other therapies require delivery to the site of the disease through catheterization or open surgical procedures, but this one is very simple and easy for the patient. "A person who has had a single, severe heart attack may survive but can ...

Study in Science holds promise for a new approach to drug therapy

...en as a lead compound in further experiments. In a standard drug discovery technique, researchers collected several compounds (21 in this case) similar to their lead compound to see if any small change to the lead would drastically affect its drug potential. Researchers tested two compounds as a proof of ge...

Botox could help target resistant tumors for treatment

...therapy and radiation treatments have remained the standard of care, tumor cells of most cancer types have shown increasing resistance to therapies. This phenomenon has resulted in more toxic dosages of chemotherapy and radiation, and increased efforts to develop more drugs to which tumors don't show resistan...

Scientists reveal how deadly toxin hijacks cells

...rk to ensure that vesicles function properly. With standard screening experiments known as "entry assays," the scientists were able to zero in on SV2. To confirm that result, they acquired mice that were genetically engineered to carry reduced amounts of SV2. Without that protein around, the researchers found...

Multi-million pound UK Biobank underway

...m, Cheshire, answering some questions, having some standard measurements taken and giving small blood and urine samples. They will also be asked to agree to allow their health to be followed by UK Biobank for many years directly through routine medical and other health-related records. The objective of the ...

Less antibiotic use in food animals leads to less drug resistance in people, study shows

...t has avoided using the antibiotics that have been standard in the other countries' food animal production. To evaluate whether the country's restrictive antibiotic policy has affected bacterial drug resistance, Australian researchers examined C. jejuni isolates collected from 585 patients in five Australian...

UCLA scientists uncover mechanism of response to targeted therapy

...ls, with their high levels of HIF, would take in a standard PET imaging probe at high levels. If that proved true, the PET scan would show that the cancer cells had increased levels of the probe. Using laboratory animals, researchers determined that kidney cancer cells were indeed better at taking up the prob...

Report finds cruise industry is protecting the precious places it visits

...ural elements in their shore excursions; implement standard operating procedures to ensure minimal negative impact on the local environment and cultures; and educate tourists about specific local regulations, laws, customs and needs. The cruise industry has grown rapidly in recent years, with average annual...

St. Jude projects 90 percent cure rate for ALL

...e enabled clinicians to identify patients for whom standard treatment is most likely to fail, and who should therefore be treated more aggressively; these findings have also allowed clinicians to choose the optimal drugs and drug dosages for individual patients. The improvements in ALL treatment are also hel...

Viral 'fitness' explains different resistance patterns to aids drugs

...RVs at high levels of pill-taking as directed. The standard combination therapy usually includes either one NNRTI or protease inhibitor (non-boosted or boosted with a small amount of another potent PI) and two different antiretrovirals from the nucleoside reverse transcriptase inhibitor class. ...

Relationship of brain and skull more than just packaging

...ngton University, looked at the reproducibility of standard anatomical features on the skull and brain. "We found that the brain landmarks people often use were highly variable and had the biggest errors in reproducibility," says Richtsmeier. "We eventually chose brain locations that were easier to identify ...

U-M researchers take new approach to defeating Gram-negative bugs

...eria, and it is considered by researchers the gold standard of Gram-negative bacteria. After their genetic modifications, E. coli was killed with just a fraction of the antibiotic dose typically needed. It was 512 times more susceptible to Rifampin, 256 times more vulnerable to Novobiocin, and eight times mo...

Study: Paramedics save more lives when they don't follow the rules

...h, first responders skipped the first steps of the standard protocol: intubating the patient for ventilation a...as only 20 percent in the 3 years before, when the standard CPR protocol was used. The current study, which involved 125 patients, reports the experiences aft...

The diversity of marine life in the Gulf of Maine region is much greater than previously thought

...cords and assured that the list is presented using standard species classifications. Though still in preliminary form, the register is a tremendously useful resource to investigators of biodiversity in the Gulf of Maine. For example, it provides a baseline against which scientists can monitor future losses ...

Berkeley researchers lay groundwork for cell version of DNA chip

... were incorporated into microfluidic chips through standard photolithography. After the DNA-coated Jurkat cells were rinsed over the chips, fluorescence microscopy revealed that only those cells coated with single-stranded DNA complementary to the anchored DNA adhered to the gold pads. Cells that were other...

Salk researchers make fast strides towards understanding how our body controls walking

...hey found that, while normal spinal cords showed a standard pattern of activity that mimics walking, the rhythmic pattern in spinals cords lacking functional V1 neurons had slowed to a crawl. "From what we knew about these cells, we were a bit puzzled at first because we had expected to see a loss of coordin...

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