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Tag: "stage" at biology news

Wisconsin scientists grow critical nerve cells

...r natural chemicals needed to guide cells from one stage of motor neuron development to another. But once p...apply a chemical known to be necessary for a later stage of neuron development to a much earlier step in the process? The hunch paid off and turned out to b...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

... diabetes by becoming overweight," she added. "The stage is set in two ways: low insulin production coupled with resistance to insulin -- a double whammy." Other researchers involved in the Joslin study included co-authors Jose C. Jimenez-Chillaron, Ph.D., Marcelino Hernandez-Valencia, M.D.; also Carolyn ...

Timing is everything: First step in protein building revealed

...he cell or lead todisease."The ribosome is the end stage of gene expression, and gene expressionkeeps us alive and causes disease," says Lorsch. "If we can betterunderstand how the ribosome works, perhaps we can harness it to help usfix disease."Already, scientists knew that without eIF1, the ribosome can ...

Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates

...n as a treatment for Parkinson disease reached the stage of humantrials over 15 years ago, however the field is still in its infancy.Researchers from Kyoto University have now shown thatdopamine-producing neurons (DA neurons) generated from monkey embryonicstem cells and transplanted into areas of the brai...

Genome-wide mouse study yields link to human leukemia

...(ALL). The mouse first goes through a pre-leukemic stage marked by rapidly expanding T cells and natural ki...system. In comparing the mice in the pre-leukemic stage and those with ALL with normal mice, researchers found that methylation, a chemical process that add...

Gene variations explain drug dose required to control seizures

...fects, he added. The findings in epilepsy set the stage for scientists to evaluate other conditions in which gene-based diagnostics might help determine the optimum dosage of particular therapies for particular patients, Goldstein said. "For most drugs we know a lot about how and where they act in the bo...

Needling Chromosomes Reveals Cell Division Secret

...eared to be two separate chromatidsduring an early stage of cell division, so it was believed that theyhad detached from one another at that time."What hadn’t been done was to attempt to separate chromatids todirectly determine whether they, in fact, are held together or not,"said Nicklas. "So, Leocadia se...

Ants Genetic Engineering Leads To Species Interdependency

...f an individual is determined forlife at a certain stage in her development.In virtually all ant species, it is the environment in which a femaleis raised, rather than a genetic predisposition, that determines whichcaste she will adopt.However, in two harvester ant populations in southern New Mexico,queens...

Gene Therapy For Parkinson's Disease Moves Forward In Animals

...ctive concept and would only be amenable for early stage patients to keep a good quality of life. It would be a huge change in the way treatment is done,?said Mandel, a neuroscientist in UF's College of Medicine. “We know the GDNF protects the neurons in primates from the model that we use, so that's good....

Scientists reveal molecular secrets of the malaria parasite

...in their vertebrate hosts and a sexual development stage during whichthe parasite is transmitted between ve...tion by comparing the genesexpressed in the sexual stage transcriptome with the proteomes of boththe sexual stage and a developmental stage in the mosquito. ...

Research Gives Hope For Liver Damage

...vanced liverfibrosis (scarring) and cirrhosis (end stage scarring of the liver).Currently, we have no effective treatment for liver cirrhosis which isassociated with internal bleeding, liver failure and the development ofprimary liver cancer. There is a huge imperative to develop newapproaches to the treat...

New Breast Cancer Test Could Save Lives

.... Currently, in order to detect cancer at an early stage ?which is extremely important for successful treat...ed, the high-tech support programme for very early stage ventures. SETsquared is part of the enterprise partnership between the universities of Bath, Bristo...

Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells

...holds promise for detecting cancer at a very early stage and could nearly eliminate delays in diagnosis and treatment." The technique is effective because "it measures changes in the cell architecture, especially those arising from alterations in protein density, cytoskeleton shape, and distribution of mi...

Gene therapy for Parkinson's disease moves forward in animals

...ctive concept and would only be amenable for early stage patients to keep a good quality of life. It would be a huge change in the way treatment is done," said Mandel, a neuroscientist in UF's College of Medicine. "We know the GDNF protects the neurons in primates from the model that we use, so that's good...

Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin

... wavelengths of near-infrared light. This sets the stage for using emissive polymersomes to target multiple cancer cell-surface markers in the body simultaneously. Emissive polymersomes perform much like in vivo imaging systems that use semiconductor-based "quantum dots." These quantum dots, however, are ...

New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines

...sults also imply that during the initial infection stage in humans, HIV may escape destruction by the immune system because these seemingly vulnerable outer coat proteins activate self-reactive antibodies. "The fundamental problem in all of HIV vaccine research has been that when you inject the envelope o...

Dead zone area in Gulf could be increasing, researchers say

...spring and early summer following the spring flood stage of the rivers, which bring large amounts of nutrients ?often in the form of fertilizer ?into the Gulf of Mexico. The Mississippi is the largest river in the United States, draining 40 percent of the land area of the country. It also accounts for alm...

Nanoscale Diagnostic Sets Sights on Alzheimer's

...echnology "It's a good bet that the very earliest stage of AD memory loss begins when ADDLs attack key syn...to validate the prediction, and maybe even set the stage for creating the first clinical lab test for Alzheimer's disease. " -- William Klein, Northwestern U...

No relief for Pacific Northwest drought

...with heavier rains, however, can sometimes set the stage for major fires in following years if drought resumes. The models that simulate the droughts and the likelihood of fire are complex and sometimes counter-intuitive, the researchers said, involving such things as vegetation growth, fuel loads, soil m...

Anti cancer virotherapy well tolerated in first human administration, research finds

...vanced melanoma tumours of these patients with end stage disease. Both patients had many sites of spread melanoma tumours and injected and non-injected tumours were subsequently removed from the patients. Professor Shafren's group observed no "systemic toxic effects or localised inflammation" as a result...

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