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Tag: "squamous" at biology news

Rising skin cancer rates are more likely to affect wealthy people, says 12-year review

...e most common skin cancers - basal cell carcinoma, squamous cell carcinoma and malignant melanoma - accounted ...rs. And men were twice as likely to suffer from squamous cell carcinoma than women, accounting for 357 of the 640 cases reported each year. Women were, h...

Cancer vaccines -- Taking a jab at cancer by stimulating the immune system

...Wild type sequence p53 as a vaccination target for squamous cell carcinoma of the head and neck: Abstract 5113... immune system into targeting p53 in head and neck squamous cell cancer. A phase I clinical trial of the vaccine is currently underway at the University of Pitt...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

...that are involved in regulating the sensitivity of squamous cell head and neck cancer cells to lapatinib, a cancer drug that was recently approved for use in metastatic breast cancer under the name Tykerb. The study, a collaboration with GlaxoSmithKline, evaluated 7,000 genetic targets in human head and n...

Signal protein shows promise for blocking tumor promoters in skin cells

... group expects to know whether Srcasm can decrease squamous cell carcinoma formation in skin, mentions Seykora. ...

Abnormal overexpression of p53 is a predictive molecular biomarker

...n Austin, Texas, found that patients with advanced squamous cell carcinoma of the head and neck cancer (SCCHN) whose pre-treatment tumor samples over-expressed p53 protein were significantly more likely to respond to Advexin therapy than those whose tumor showed little p53 protein. Advexin is a gene based dru...

Long-term cancer risk follows stem cell transplant recipients

...second cancers were cancers of the skin (basal and squamous cell), lung, oral cavity, and colon. Furthermore, data analysis showed that the risk more than tripled for patients who received their transplant when they were over 40 years of age. The study also identified a new risk factor: patients who recei...

Gene first linked to rare disease may trigger skin cancer, other tumors

...idermis, including basal cell carcinomas (BCC) and squamous cell carcinomas (SCC). BCC and SCC represent the two most common forms of skin cancer, which together affect an estimated one million Americans each year. "Interestingly, we observed reduced or absent expression of CYLD in more than ten samples of ...

Biomarkers may hone anti-aging therapies

...cer, particularly the most common forms: basal and squamous cell carcinomas. Sligh and colleagues were surprised to find a panel of mitochondrial DNA deletions in the tumor-free skin that was adjacent to the tumors, but not in the tumors themselves. The tumor samples were more likely to have full-length mito...

HPV subtype associated with squamous cell skin cancers

...of developing a major type of skin cancer known as squamous cell carcinoma (SCC), according to a new study in the March 15 issue of the Journal of the National Cancer Institute. In addition, the presence of antibodies to multiple types of HPV was associated with the highest risk of SCC, but the associatio...

Forsyth scientists find three bacteria associated with oral cancer

...r bacteria in saliva indicate the presence of oral squamous cell carcinoma (OSCC)--one of the deadliest of cancers because it often goes undetected in its early stages. "Finding bacteria associated with OSCC encourages us to hope that we have discovered an early diagnostic marker for the disease," said Donna...

Compound from Chinese medicine shows promise in head and neck cancer

... their team treated cell cultures of head and neck squamous cell carcinoma with the (-)-gossypol compound and found it inhibited tumor cell growth. Additional testing in animals was also positive and showed (-)-gossypol did not harm surrounding healthy tissue. Researchers hope to begin a clinical trial in he...

Study: Harmless virus kills some cancers

...using virus to kill cervical, breast, prostate and squamous cell cancer cells in laboratory cultures, accordin...ur types of cancer ?cervical, breast, prostate and squamous cell - all epithelial cell cancers. Epithelial cells are those that cover or line all of the interna...

High-powered gene profiles provide clues to genes involved in common form of lung cancer

...he two major subtypes of NSCLC, adenocarcinoma and squamous cell carcinoma, and found that their genomic profiles overlap in every area but one: squamous cell carcinomas contain an area of gene amplification, or over-copying, not found in adenocarcinomas...

Biomarkers isolated from saliva successfully predict oral and breast cancer

...tic "biomarkers" isolated in saliva predicted oral squamous cell carcinoma in about nine out of 10 cases. A r...aliva and blood from 32 patients with primary oral squamous cell carcinoma and 40 breast cancer patients, and matched each with saliva and blood from otherwise ...

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