Tag: "splice" at biology news

Molecular machine may lead to new drugs to combat human diseases

...can use this knowledge to manipulate the intron to splice out malfunctioning genes, said Barbara Golden, ass...ting because they cause their own removal and also splice the ends of the surrounding RNA together, forming a functional gene," Golden said. "We can design in...

Products containing specific probes for detecting alternative splice forms protected

...of five oligonucleotides for the detection of each splice variant. There are many applications for this patent, including drug discovery, diagnostics, and compound screenings for efficacy or toxicity as well as screening patients for potential efficacy of therapeutics. Alternative RNA Splicing is a critica...

Cellular Defects in Premature Aging Disease are Reversible

...GPS cells because the mutation creates an aberrant splice site in the lamin A gene; the aberrant splicing, o... be able to degrade ?that would bind to the mutant splice site and prevent the splicing machinery from cutting in the wrong place. "You can think of it as a m...

Carnegie Mellon University research reveals how cells process large genes

...ce through direct splicing. Mutations at recursive splice sites may cause additional diseases, but until now...Lopez said. Lopez found that predicted recursive splice sites were 10 times more likely than expected to be found in introns greater than 200 kilobases in l...

Reversal of role for a viral protein associated with the development of lymphoma

...ce through direct splicing. Mutations at recursive splice sites may cause additional diseases, but until now...Lopez said. Lopez found that predicted recursive splice sites were 10 times more likely than expected to be found in introns greater than 200 kilobases in l...

Modification of program enables prediction of gene transcription

...gene transcription start sites and where the first splice occurs thereby defining the first exon of the gene... systems ?except for N-SCAN ?either ignore the UTR splice sites or incorrectly incorporate them into some protein-coding segment, making gene prediction a non...

Single gene is genetic switch for fly sexual behavior

... the researchers. Males with the female fruitless splice form were also more likely to court other males than flies with the male form, suggesting that male-specific fruitless splicing "not only promotes male-female courtship, it also inhibits male-male courtship," the researchers say. Dickson and Demir r...

North & South American researchers find architectural abnormalities in T. cruzi ribosome

... other eukaryotes," Frank said. "For instance, the splice leader of the mRNA might attach at the turret, which may swivel out and drag the mRNA across the binding site on the ribosome to initiate protein translation." The findings may also advance studies of parasitic relatives Trypanosoma brucei, which ca...

RNA splicing occurs in nerve-cell dendrites

...red that nerve-cell dendrites have the capacity to splice messenger RNA (pre-mRNA), a process once believed to only take place in the nucleus of cells. By uncovering this capability in dendrites, the investigators hope to relate this capacity to memory and learning, as well as cognitive dysfunction. Senior...

New method for identifying microbes

...bes apart. In one example, the scientists cut and splice pieces of DNA to produce "tags" that contain 16 "letters" of genetic code somewhat "upstream" from the beginning of the gene that codes for a piece of the ribosome -- the highly conserved "single point" reference gene. By sequencing these tags and co...

Protein splicing upsets the DNA colinearity paradigm

...lgium/USA team has found that proteasomes can also splice the peptide fragments together in a reverse order to that encoded by the protein's DNA sequence template. This takes the possible number of antigens from any one protein into potentially thousands of sequence configurations. The sequence of the fi...

Living view in animals shows how cells decide to make proteins

...ells use a critical biological process to dice and splice genetic material to create unique and varied proteins. The scientists say the findings, made in mice, help explain a key wonder of human biology: how the same genes found in every cell of an individual’s body can produce different proteins in differ...

NIH neuroscience microarray consortium launches high-throughput genotyping services

...orm and uses the Affymetrix exon arrays to look at splice variants, in addition to the new Illumina expression and genotyping capabilities. The principal investigator at Yale, Shrikant Mane, says that the "Illumina platform provides an important complement to the other technologies currently available t...

Gene mutation linked to cognition is found only in humans

...ecessary but also sufficient in creating the novel splice form," the authors state. The results also sh... suggests that before the emergence of the type II splice form in human, the weakening of the type I splicing site already existed in the common ancestor of h...

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