OHSU lab finds meth receptor that could lead to therapy
...chairman of physiology and pharmacology. "Chemical space ?that is, the number of possible drug molecules th...xist ?is incredibly large. Our aim is to mine that space in order to uncover novel therapies." TAAR1 was originally discovered in the laboratory of David ...MIT device draws cells close -- but not too close -- together
...'s first thoughts about how to solve this cellular space and time problem involved another children's game: plastic puzzles with squares that slide around on a grid. They wondered if they could put different cells on each square and then move them around. This idea quickly evolved into an elegant tool ...One-of-a-kind imaging probe reveals secrets useful for drug discovery
... probe is only about 2 inches in diameter, and the space for the sample itself is about 1 millimeter in diameter. When in use, the probe is cooled to lower than 400 degrees Fahrenheit below zero to reduce electrical signals that would interfere with the analysis. But the sample area itself is kept warm to...Protein structure initiative launches new resources for the scientific community
...hese developments have reduced the cost, time, and space needed to carry out structural studies, as well as improved the generation and analysis of quality data....Two nerve cells in direct contact
Movements in space create in humans and animals so-called optical flow fields which are characteristic for the movement in question. In a forward movement, the objects flow by laterally, objects at the front increase in size and objects further away hardly change at al...Hopkins researchers discover how brain protein might control memory
...in the brain, one cell releases chemicals into the space between it and its neighbor. The neighboring cell has protein receptors on its surface that capture the released chemicals. The cell that captures these chemicals then swallows up the receptor-chemical complexes, removing the receptors from the cell'...Scientists win grants to develop $1,000 genome sequencing technology
...te dedicated to fostering radical breakthroughs in space and technology for the benefit of humanity. "The $10 million prize may be a nice incentive to researchers, but our group at UCSD is more excited about the challenges of overcoming the daunting technical obstacles that must be overcome to develop a...Sandia researchers discover way to see how a drug attaches to a cell
...d with light, photocatalysts located in the narrow space between the two layers of the lipid transfer electrons to the platinum ions. The uncharged platinum atoms gather into tiny metal clumps. Once they reach a certain size, they also become active and catalyze the dendrite growth by adding more platinum ...'Trojan Horse' agent halts bone metastasis in mice
...s and chew up bone tissue, providing the tumor new space to grow. The mature osteoclast cells themselves do not express the Flt-1 receptor. According to Rosenblum, the VEGF121/rGel agent entered the immature cells via the Flt-1 receptor and destroyed them, shutting down tumor growth. "This was a surpr...Climate experts search for answers in the oceans
...ing a means of detecting these tiny organisms from space with dedicated ocean colour sensors. "Because ...ars there has been a concerted effort by the world space agencies to share and develop satellite ocean temperature measurements together for the benefit of a...Squid-inspired design could mean better handling of underwater vehicles
...as the advancement of terrestrial, atmospheric and space research aimed at benefiting humanity. "Reliable docking mechanisms are essential for the operation of underwater vehicles, especially in harsh environments," Mohseni said. "We set out to resolve the trade off that many researchers settle for, w...Detecting microalgae in coastal waters
...cterize algal populations that change quickly over space and time. In vogue are fluorescence-based optical monitors that 'see' chlorophyll a, a plant pigment that is present in all algal species. However, these tools are less effective in turbid coastal waters and do not identify alternative pigments, so c...Ferns provide model for tiny motors powered by evaporation
...To make the device move, Borno said, they load the space between the ribs with water, and when the water evaporates, the surface tension of the water pulls on the tips of the ribs so that the tips move toward each other, straightening out the spine of the device. In this way, the closed device opens wide--...Uniform tungsten trimers stand and deliver
... the distance from the microscope's tip to a small space between atoms," White explained. The collaborators also characterized the cluster mass, determined the ratio of tungsten to oxygen atoms in the cluster, and used X-ray photoelectron spectroscopy to identify the tungsten oxidation state. "This is a ...Cellular traffic backups implicated in skeletal malformations
...e proteins either empty out into the extracellular space or take up residence in the cell membrane. "Protein transport and secretion is a fundamental function of every living cell, in every organism," said Knapik, associate professor of Medicine and Cell and Developmental Biology. Similar mutations in ...Mars mission Risk 29: Scientists research ways to reduce radiation-induced brain damage
...t a roadmap laying out 45 risks to astronauts in a space mission that is likely to last two years. Those ri... oxidative metabolism in the biological effects of space radiation Susan Bailey, Colorado State University, Fort Collins, Colo., telomeric proteins in the...Bacteria that use radiated water as food
... 25 million years ago. The bacteria's rocky living space is a metamorphosed basalt that is about 2.7 billion years old. How surface-related Firmicutes and other species managed to colonize an area so deep within Earth's crust is a mystery. Some surface Firmicutes species are known to consume sulfate and ...China's environmental challenges
...ral areas. In the city of Guangzhou, for example, space between residential buildings is so tight that people refer to them as "handshaking buildings." City clusters often enhance the competitiveness of a region, catalyzing economic growth. The downside is the environmental pollution wrought by rapid ur...Steep oxygen decline halted first land colonization by Earth's sea creatures
...d Ward, a UW professor of biology and of Earth and space sciences. He notes that atmospheric oxygen rose sharply at the end of the Silurian period about 415 million years ago, to reach a level of about 22 percent of the atmosphere, similar to today's oxygen content. But 55 million years later, atmospher...With record resolution and sensitivity, tool images how life organizes in a cell membrane
... for characterizing hard materials, such as rocks, space dust, polymers and nanoelectronics. But in the last five years, biologists have become interested in employing it to characterize components of biological samples on a length scale of 100 nanometers or less. ''There's currently no way to do that,'' ...