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Tag: "sought" at biology news

Cells re-energize to come back from the brink of death

...se activation, but they also foil CIDC. “Our study sought to understand how a cancer cell without caspase activation bypasses CICD as well,” Green said. The St. Jude team discovered that a cell that lacks caspase activation and cannot undergo apoptosis increases the levels of an enzyme called GAPDH in ...

In mice, drug protects against diabetes and atherosclerosis

...was clear in both mice and humans, the researchers sought to reproduce the effects of these genetic mutations through the development of drugs. Hotamisligil worked with Dr. Rex Parker at the Bristol-Myers Squibb Research Institute in Princeton, NJ, to develop an inhibitor of the aP2 protein. "There was n...

U-M researchers discover gene switched off in cancer can be turned on

...cation of the journal Oncogene. The researchers sought to understand why BRM is not expressed in certain cancer cell lines. They found no mutations to the gene but rather that it was just silent – essentially like a switch that had been turned off. Knowing that a class of drugs called histone deacetylase...

Physicist cracks women's random but always lucky choice of X chromosome

...remely uncomfortable with this randomness and have sought a clear scientific reason as to why one X chromosome was switched off rather than the other. The observations also seem to run counter to the usual idea that the biological mechanisms evolve in ways that allow a "best" choice to be made between thing...

In nature, proteins sweep up nanoparticles

...ggregation,” says Banfield. The scientists also sought to understand the mechanism by which proteins promote nanoparticle aggregation. They found that the presence of cysteine, an amino acid that is a building block to most proteins, yielded the most extensive and prolonged aggregation, with some blobs m...

Study identifies 5 genetic themes key to keeping stem cells in a primitive, flexible state

...become increasingly powerful, many scientists have sought a more molecular definition of stem cells, based on the genes they express. Now, a team of Canadian scientists has identified 1,155 genes under the control of a gene called Oct4 considered to be the master regulator of the stem cell state. A compre...

How to look at dinosaur tracks

...acks at all.? With this in mind, Milàn and Loope sought to describe and categorize different levels of preservation. For example, dinosaur tracks may still exist as true tracks, that is, the original prints left in the ground by the dinosaur. True tracks preserve many of the anatomical details of the foot...

Hearts of male and female rainbow trout are different

... stimulation of PDH than males. The study also sought to determine if sodium cyanide (NaCN) -- an inhibitor of oxidative metabolism ¡V decreases activity of the glycolytic pathway and cardiac performance in both sexes, and if males possess a larger outermost (epicardial) layer of the ventricle vs. the i...

Gene malfunctions cause schizophrenia, depression symptoms in mice

...ll Press. In their experiments, the researchers sought to explore the consequences of mutating a gene called "Disrupted in schizophrenia 1" (DISC1), which had been found in one family to be associated with schizophrenia, bipolar disorder, and major depression. The researchers' theory was that differen...

Researchers attach genes to minichromosomes in maize

... stacked on the minichromosomes. “This has been sought for a long time in the plant world, and it should open many new avenues. If we can do this in plants, many advances could be done in agriculture that would not otherwise be possible, from improved crops to inexpensive pharmaceutical production to oth...

Deconstructing brain wiring, one neuron at a time

... connected to which. The team of Salk researchers sought to create a modified virus whose spread could be limited to a single synaptic connection. "The core idea is to use a virus that is missing a gene required for spreading across synapses but to provide the missing gene by some other means within the...

Discovery of new cave millipedes casts light on Arizona cave ecology

... lived in leaf litter. As the climate warmed, they sought refuge in caves, where the subterranean realm provides more constant climatic conditions enabling their survival. Representing two distinct species (one occurring in one cave on the South Rim, the other in two caves on the North Rim of Grand Canyo...

New success in engineering plant oils

...eresting challenge," remarked Shanklin. "Our group sought to gain a better understanding of the enzymes and metabolic pathways that produce these oils to find ways to manipulate the accumulation of fats using genetic techniques." The researchers focused on an enzyme known as KASII that normally elongates...

Gene variations contribute to aggression and anger in women

...s. In the study being presented today, researchers sought to determine if this relationship was genetically determined. The study is the first to look at the relationship between variations in the serotonin receptor 2C gene and anger and hostility. Completed at the University of Pittsburgh's Behavioral P...

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease

...s fundamental biology. The researchers then sought to extend their insights to the use of human stem cells - either stem cells turned into neural progenitors from human embryonic stem cells - or isolated directly from the nervous system (called "adult" stem cells to distinguish them from embryonic st...

Migration played key role in HIV spread in South Africa

... author Jeanette M. Tetrault, M.D., and colleagues sought to find the relationship between marijuana smoking and pulmonary function or respiratory complications. "While there is convincing data on the effects of tobacco smoke on pulmonary clinical outcomes, the effect of marijuana smoke has been poorly ...

Long-term marijuana smoking leads to respiratory complaints

... author Jeanette M. Tetrault, M.D., and colleagues sought to find the relationship between marijuana smoking and pulmonary function or respiratory complications. "While there is convincing data on the effects of tobacco smoke on pulmonary clinical outcomes, the effect of marijuana smoke has been poorly ...

Scientists unveil piece of HIV protein that may be key to AIDS vaccine development

... and destroy multiple HIV strains. Scientists have sought such broadly neutralizing antibodies by studying the blood of people whose immune systems appear to hold the virus at bay for long periods of time—b12 is one of these rare, broadly neutralizing antibodies. Until now, no one had succeeded in determ...

Trojan horse strategy defeats drug-resistant bacteria

...ents that best killed bacteria in test tubes, they sought to intensify the stress imposed on microbes by one of the body's own defense mechanisms. "The competition for iron is critical in the struggle between bacteria and host," explained the study's senior author, Pradeep Singh, associate professor of ...

Eating less salt could prevent cardiovascular disease

...about cardiovascular and other health problems was sought from participants in the earlier trials. As part of this researchers found that participants who had cut back on salt during the trials tended to stick to a lower salt diet compared to those who had been in the control group. In total the researchers...

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(Date:7/9/2014)... era of increasing concern about the prevalence of ... a promising new pathway to disabling disease: blocking ... The scientists showed how bacterial siderophore, a small ... to fan bacterial growth as well as ... this infection process. Their findings appear in a ...
(Date:7/9/2014)... many backyard cooks are turning to more healthful alternatives ... fat can sometimes mean low satisfaction. Now researchers are ... low-fat wieners that are made with olive oil rather ... Journal of Agricultural and Food Chemistry . , ... have come to expect just the right amount of ...
(Date:7/9/2014)... fossil from China challenges the commonly held belief that ... ability to fly. The birdlike fossil is actually not ... remains of a tiny tree-climbing animal that could glide, ... in Blanding, Utah, and Alan Feduccia of the University ... Journal of Ornithology . , The fossil of the ...
Breaking Biology News(10 mins):Bacteria hijack plentiful iron supply source to flourish 2Researchers declassify dinosaurs as being the great-great-grandparents of birds 2
(Date:7/9/2014)... The National Institute of Allergy and Infectious Diseases ... has launched an early-stage clinical trial of CRS3123, ... Clostridium difficile ( C. difficile ) infection. ... agent that inhibits C. difficile growth while sparing ... will enroll up to 30 healthy men and ...
(Date:7/9/2014)... poor printing on prescription labels handed out by ... errors in taking medication, according to new research ... National Institute for the Blind)., The study, published ... found that labels on prescription medications dispensed by ... for legibility. , By simply following recommended guidelines ...
(Date:7/9/2014)... A study published in the scientific journal ... Bonin, two researchers at Universit Laval, reveals that it ... method that involves rekindling pain so that it can ... means to alleviate chronic pain. , The researchers from ... universitaire en sant mentale de Qubec (IUSMQ) were inspired ...
(Date:7/8/2014)... and cardiovascular health as other healthy mature individuals, according ... Journal of Transplantation . The findings may provide some ... professionals caring for them. , Over the past two ... and older has become more common. Given the links ... removal of a kidney could make older donors vulnerable ...
(Date:7/8/2014)... A team of clinicians from Plymouth, UK, and Sydney, ... 10th July Australia) launched ACEmobile - a free-to-use app ... , ACEmobile is the first of its kind; an ... tool provides support through the whole process, meaning more ... out this type of assessment. Designed by clinicians for ...
Breaking Medicine News(10 mins):Health News:NIH launches Phase I clinical trial of novel drug to treat Clostridium difficile infection 2Health News:Most prescription labels fail to meet guidelines, risking dosage errors 2Health News:Discovery of a new means to erase pain 2Health News:Study finds kidney donation safe for healthy older adults 2Health News:New app widens opportunities for dementia assessments 2Health News:New app widens opportunities for dementia assessments 3
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