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Bound for destruction: Ubiquitination protects against improper Notch signaling

...all change in cell fate and amplify it,acting as a sort of contrast enhancement mechanism in cell fatedetermination. Notch is activated bya protease that is present ubiquitously in the cell membrane. What haslong remained a mystery, however, is the question of how Notchreceptors that have not been activa...

MSI releases 'moleculizer' - a new approach to simulation of intracellular biochemical networks

...omic research projects."Moleculizer is exactly the sort of development that one wants to seefrom multidisciplinary work," explained Dr. Brent. "The mathematicaland algorithmic skills that Dr. Lok brought to the problem could onlycome from one with his strengths, but the work is important because itaddress...

Ice core 'dipstick' indicates West Antarctic ice has thinned less than believed

...archers, an ice core of 1,000 meters was used as a sort of dipstick to show that a key section of the West Antarctic Ice Sheet probably never contained as much ice as scientists originally thought it did. That means it couldn't have contributed as much to the higher sea level. In an area called Siple Dom...

RNA project to create language for scientists worldwide

...tion scientists and structural biologists. To help sort out the difficult conceptual issues, the consortium will organize frequent face-to-face meetings of RNA scientists. Members will also report their progress at the annual RNA Society meetings and receive feedback from the wider community of researcher...

World's largest rainforest drying experiment completes first phase

...ved during the five-month dry season each year. To sort out the forest responses to the "umbrellas" from the normal variation in tree growth, tree death, leaf production, and other aspects of forest behavior, researchers compared this dry plot of forest with a similar plot, from which rainfall was not exc...

Mayo Clinic Researchers Create 'Obedient Virus'; First Step To Use Measles Virus Against Cancer

...I saw the data, I was completely stunned. It's the sort of thing that, having worked on targeting viruses for about 15 years, I just couldn't believe that we'd finally got what we'd been hunting all that time," says Stephen Russell, M.D., Ph.D., lead researcher and director of Mayo Clinic's Molecular Medi...

Researchers identify protein crucial for survival of Lyme-disease bacterium

..., and no nutrients are coming in, the bacteria are sort of in a quiescent state, waiting in the tick's midgut, which is equivalent to our digestive system." When blood enters the tick gut, Dr. Norgard said it appears that changes in temperature and acidity signal the bacteria that the nutrient is present...

Glow-in-the-dark zebrafish at UH hold keys to biological clocks

...nce, however, we determined that it does take some sort of environmental input for the clock to start. In this case it was exposure to light/dark cycles after the fourth day of development, about the age when the fish start to swim and feed." The researchers used zebrafish (danio rerio) because they yiel...

Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive

...ple with autism don't understand or experience any sort of emotional attachment or romantic love. I would speculate that autism involves an atypical development of the midbrain and basal ganglia reward systems. This makes sense, too, because other symptoms of autism include repetitive thoughts and movemen...

Grasping metaphors: UC San Diego research ties brain area to figures of speech

...spondents succeed at this task ?of translating one sort of sensory information into another ?patients with damage to the angular gyrus performed at the level of chance. Three age-matched control subjects, on the other hand, with lesions in other areas of the brain, performed normally both with proverbs a...

Shutting down the HIV assembly line

...rotein complex," a group of four proteins known to sort cargo proteins to specific compartments in the cel...tep in HIV particle assembly, an inhibitor of this sort would be expected to block viral replication in cells that complete assembly at the multivesicular b...

Study reveals dramatic difference between breast cancers in US and Africa

...inary effort based at the University of Chicago to sort out the genetic and environmental factors that contribute to breast cancer. The study will look at the genes, lifestyle, socioeconomic status, and social interactions of women in the United States and Africa and their relationship to breast cancer. ...

Brain May Be Less Plastic Than Hoped

...you can design lesions and test pharmaceuticals to sort out what kind of reorganization the brain is capable of after, say, a stroke. It's a powerful way to stimulate and study reorganization that may turn out to be beneficial in the future.?/p>...

Retrovirus struck ancestors of chimpanzees and gorillas millions of years ago, but did not affect ancestral humans

...much smaller group of surviving animals would then sort out most of its genetic variation in relatively fewer generations than would a larger group. This would lead to a higher probability of rare genetic variants becoming fixed in a short time. Before long, a genetically disparate population, possibly wi...

Hydrogen and methane provide raw energy for life at 'Lost City'

...nts by at least 100 feet. Some places resemble the sort of deposits one might see in spectacular caves with spires and smoothly rippled surfaces in a complex three-dimensional array, says Duke University's Jeffrey Karson, co-author on the paper. Another marked difference being published for the first tim...

At the molecular level, the predator is the prey

...cation one-upsmanship. "One might think that this sort of change in the sodium channel would be too costly to the snakes," said Utah State University biologist Shana Geffeney, who conducted the gene expression experiments. "What will be interesting in the future is to understand if there is a balance bet...

Researchers pioneer new gene therapy technique using natural repair process

...re not always successful. "SCID is ideal for this sort of therapy because you only need to correct the defect in a small number of immune cells to fix the problem," said Dr. Porteus, assistant professor of pediatrics and biochemistry at UT Southwestern. "This is called selective advantage; the healthy ce...

Tamoxifen-like drug suggests new ways to selectively block estrogen

...e at Argonne National Laboratories are making this sort of once-grandiose plan more realistic, Greene said. "We used to solve the structures of one or two molecules a year. Now we have 40 to 50 in progress." GW5638 was developed as a variation on tamoxifen in the early 1990s by co-author Tim Willson and ...

Researchers reveal secret of key protein in brain and heart function

...scaffolding" protein. In this role, it serves as a sort of tether, grabbing proteins inside the cell critical to nerve signaling and keeping them close to N-methyl-D-asparate (NMDA) receptors at the cell surface. NMDA receptors help usher in a neurotransmitter called glutamate that is essential for learni...

Team Invents Device For Weighing Individual Molecules

...m with identifying these proteins is that one must sort through millions of molecules to make the measurement. You need to be able to pick out the 'needle' from the 'haystack,' and that's hard to do, among other reasons because 95 percent of the proteins in the blood have nothing to do with cancer." The ...

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