Polymer gel can block toxic leakage problem in gene therapy
...journal Cancer Research the researchers proposed a solution to the viral escape problem in the form of a polym...ace viral dissemination showed that "the poloxamer solution could significantly reduce the transgene expression in the liver and increase the transgene expressi...Researchers: Treated wood poses long-term threat
...ons have to deal with," Schert said. One possible solution is to require linings, Schert said. However, that might put many of the landfills out of business. "This would probably lead to much more illegal dumping of construction-and-demolition waste in remote, rural and agricultural locations," he said. "Il...Did feathered dinosaurs exist?
...wever, mounting evidence suggests that "a possible solution to the disparate data is that Aves plus birdlike maniraptoran theropods (e.g., microraptors and others) may be a separate clade, distinctive from the main lineage of Theropoda, a remnant of early avian radiation, exhibiting all stages of flight and f...Free-energy theory borne out in large-scale protein folding
...m to unfold. The team then injected water into the solution very fast, diluting the mixture and causing the proteins to fold. Using spectroscopy, they captured fluorescence and ultraviolet polarization patterns given off by the proteins as they folded. "The novelty of this work is the direct and quantitative......d Interfaces in Potsdam have now provided a simple solution to this puzzle. If the cargo is pulled by several motors as shown in Fig.1, any motor that unbinds from the filament will stay close to that filament as long as the cargo and filament are still cross-linked by at least one bound motor. In such a situ...Switching to new anti-bacterial targets: Riboswitches
...hey suggest that a longer term and more attractive solution is to create entirely new drugs that target bacteria in completely new ways. This approach lengthens the useful clinical lifetime of a drug and makes it possible to tackle resistant 'superbugs' with combinations of drugs. The analog, pyrithiamine, ...Asleep in the deep: Model helps assess ocean-injection strategy for combating greenhouse effect
...rature and pressure, liquid CO2 becomes a gas. One solution is to make the droplets smaller. "Droplets injected to a depth of 800 meters will rise, but if they are small enough they should dissolve completely before reaching the liquid-gas transition depth---assuming everything works perfectly," said Zhang, ...ASU researchers 'wire' DNA to identify mutations
... are attached to the ends of DNA. A drop of a DNA solution is then placed between the two electrodes. The DNA sticks to the surface of the electrodes spontaneously. As the tip is pulled away and the two electrodes teased apart, the molecules of DNA are eventually dispersed to the point of measuring the curr...Study finds that nutritionally enhanced rice reduces iron deficiency
...Nutritional experts correctly advise that the best solution is a balanced diet of fruit, vegetables and meat, but, for the very poor, such choices are simply not possible and so they depend predominantly on staple foods to stave off day-to-day hunger. This is especially true in isolated rural areas where und...Engineers discover why toucan beaks are models of lightweight strength
...fibers that looks as if it was dipped into a soapy solution and dried, generating drum-like membranes that interconnect the fibers. The result is a solid "foam" of air-tight cells that gives the beak additional rigidity. "The beak is mostly air," said Meyers. "While the inner part of human bone also contains...Diabetes researchers pioneer islet cell xenotransplantation in primate studies
...esearchers say represents a promising intermediate solution to the critical supply problem in clinical islet cell transplantation. "Our work at the U of A and Emory, along with recent work at the University of Minnesota, is very exciting and shows that xenotransplantation in humans may soon be possible, thus...Frog’s ear canal may provide insights for understanding human hearing loss
...ve. "Our research points out an elegant and novel solution to the problem of communication in high levels of background noise," said Peter Narins, UCLA professor of physiological science and ecology and evolutionary biology, and co-author of the study. "In addition, we now add amphibians to the small group o...Plants give pests sock in the gut
...f the matrix using blue dextran, a fermented sugar solution commonly used as a molecular size marker. Results showed that Mir1-CP created holes in the matrix. To replicate the test in vivo, the researchers fed caterpillars with plants susceptible to the insects and those resistant to them. Results indicate ...Simple idea to dramatically improve dengue vaccinations
...nown Dengue viruses, and it suggests a very simple solution ?injecting the four vaccines simultaneously at different locations on the body. A mosquito-born disease, Dengue kills tens of thousands of people per year and sickens 100 million more. Known as "bone-break disease," Dengue is characterized by excruc...Genetic and environmental influences on alcohol consumption among rhesus monkeys
... both aspartame-sweetened (8.4% v/v) alcohol-water solution as well as water for one hour each day during early afternoon for a period of five to seven weeks. "This study demonstrates that additive genetic factors contribute to the observed inter-individual variation in the consumption of alcohol in rhesus,...Powerful technique for multiplying adult stem cells may aid therapies
...IGF-2. When Zhang purified IGF-2 and added it in a solution to hematopoietic stem cells that he had isolated, the stem cells increased eight-fold in number. Zhang then discovered that two more growth factor proteins, Angiopoietin-like 2 and ?, abbreviated as angpt12 and angpt13, were also abundantly express...Nanotechnology may find disease before it starts
... Medicine and Biology. The researchers injected a solution of silica nanoparticles into the tail vein of each mouse. They then anesthetized the animals and placed them on their backs on a warm imaging table. Rosol said that Liu and her team are working on creating biodegradable nanoparticles. For the purpos...UCI researchers discover key factor for survival of human embryonic stem cells
... The work by Donovan and Lock provides a potential solution to the problem. By treating stem cells in culture with chemicals that block the action of neurotrophins on hES cells, Donovan said, scientists can kill the undifferentiated stem cells before they are implanted into the body. According to Donovan, t...UW-Madison engineers squeeze secrets from proteins
...t research in this area looked at proteins in free solution when in fact, most proteins are confined in some way," says Juan de Pablo, a chemical and biological engineer at the University of Wisconsin-Madison. "What we demonstrate for the first time is that the stability of proteins under severe confinement, ...Newly discovered protein kills anthrax bacteria by exploding their cell walls
...workers rely on to sterilize contaminated areas, a solution based on the protein would be a powerful tool for ...them, usually in a matter of minutes. The combined solution could be used in buildings, on transportation equipment, on clothing, even on skin, providing a safe...