Cellular message movement captured on video
...cells rigidly attached to microscope slides. Those snapshots of fixed cells can’t reveal paxillin movement. “We can now see the dynamics of how paxillin and other proteins move inside the cell with new fluorescent labels and live-cell video microscopy,” said Chien, director of the Whitaker Institute of Biom...Catching cancer's spread by watching hemoglobin
...he imaging is fast enough, researchers can capture snapshots of blood flow in individual vessels. Moving beyond mere imaging, the technique can detect the difference between oxygen-carrying hemoglobin (oxyhemoglobin) and oxygen-lacking hemoglobin (deoxyhemoglobin). This is important for monitoring tumors, beca...Anthrax paralyzes immune cells with lethal toxin, UF research shows
...thwick said. The team compared before and after snapshots of neutrophils exposed to a purified form of the toxin, as well as images showing how protein expression changed in cells. After scrutinizing the images for hours, During finally identified one protein that seemed to disappear upon exposure to anthra...Decoding protein structures helps illuminate cause of diabetes
...ays. The group now plans to capture series of snapshots during individual folding reactions to identify multiple phases as the proteins convert from an unordered mishmash into flat sheets, then coil into fibers. "No matter how fast they're moving, we can take pictures of them," says Zanni. Without th...Darwin's famous finches and Venter's marine microbes
...ironmental genomics) that seeks to examine genomic snapshots taken directly from the environment. "Metagenomics allows us to sample the 99 percent of all bacteria that won’t grow in the lab," explains Manning. "GOS opens a huge window into biological and genomic diversity and, within this diversity, to bet...Scientists get best look ever at water-life connection
...r of physics, used ultra-fast laser pulses to take snapshots of water molecules moving around a protein taken from a common bacterium, Staphylococcus. The key to getting a good view of the interaction was to precisely locate an optical probe on the protein surface. They inserted a molecule of the amino acid t...Scientists take 'snapshots' of enzyme action
...ate). "These crystal structures give step-by-step snapshots of different stages of the catalytic action," Swaminathan says, "and reveal a mechanism that is different from what had been known about this process." Previously, it had been believed that all the "players" -- the enzyme, cofactor, and substrate --...High resolution 'snapshots' detail dynamics of a cocaine antibody
... a direct impact on public health issues. With the snapshots of the complete cycle of the cocaine antibody catalytic reaction, we have shed new light on the sequence of events in an antibody-mediated reaction and provided a rare glimpse of the structural dynamics involved. With this information, it's possible ...Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool
...Bar-Joseph said. "DNA microarrays only take static snapshots of gene activity over time. In between these snaps...d carries out a similar analysis of the microarray snapshots by "checking" the sum of a set of DNA microarray data points over time (a time series experiment) ag...Image of myosin-actin interaction revealed in cover story of Molecular Cell
...action. Using electron-cryo microscopy to take 3D snapshots of myosin V and actin interacting, researchers wer...n had not been possible. The Hanein group captured snapshots of Myosin V at several points during a hydrolysis cycle. Their use of electron cryo-microscopy made...PET/MRI scans may help unravel mechanisms of prenatal drug damage
... that is picked up by the PET scanner, which takes snapshots of the tracer's location over time to show how much and how quickly the cocaine (and/or the metabolic byproducts that retain the carbon-11) enters and clears the various organs. The radiotracer decays and completely clears from the animal's body in a...... archive of the snail's life. The analyses give us snapshots of what the conditions were like in that lake basin." The geochemical analyses confirmed that the water was a stable standing body for many years. "Strong evaporation of the lake, enough to shrink it substantially in volume and make it more saline w...