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Man and mouse share genome structures

...er regions near genes. The researchers think these sites have important regulatory functions, because the methylation patterns are similar in comparable portions of the mouse genome. Until now, they'd been missed by more standard genome analysis tools. Most exciting to Bernstein is the unusual density of ...

UCSB scientists probe sea floor venting to gain understanding of early life on Earth

...cal manifestations of hydrothermal activity at two sites on the sea floor to the west of Central America ar...cal manifestations of hydrothermal activity at two sites on young abyssal hills flanking the East Pacific Rise, a fast-spreading portion of the global mid-oc...

Tiny particles could solve billion-dollar problem

...t is found at 60 percent of the contaminated waste sites on the Superfund National Priorities List, and it ...dered one of the most hazardous chemicals at these sites because of its prevalence and its toxicity. Human exposure to TCE has been linked to liver damage, i...

Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible

...study and providedtechnical assistance to the four sites carrying out the study. ArdaisCorporation, Lexington, Mass., provided the RNA samples used foranalysis....

New Technique for Tracking Gene Regulators

... Cell, where they describe thehuman-genome binding sites of a regulator protein known as CREB.“Though scien...cientists have identified some 6,302genome-binding sites for CREB, including many that are located nearknown genes. Genes identified as being regulated by CR...

Molecular machine may lead to new drugs to combat human diseases

...rystallized introns reveal their structure and the sites at which they bind with various molecules to cause biochemical reactions. Scientists can use this knowledge to manipulate the intron to splice out malfunctioning genes, said Barbara Golden, associate professor of biochemistry. Normal genes then can t...

Solution to Pollution: New Bacteria Eats Toxic Waste

...ion and survive in the environment so contaminated sites around the world can reap the benefits. Collaborations are currently under way in Nizhnekamsk in the Russian Federation to assist with the treatment of industrial residues, in Poland to renew soils for agricultural production and in the Netherlands t...

Vital step in cellular migration described by UCSD medical researchers

...ut of the cell. These protrusions serve as tractor sites for migration as the cell moves toward its intended target. If Rac were active throughout the cell, it would extend protrusions in all directions, in essence keeping the cell in one place. Until now, researchers have had limited understanding of the...

New Study from Affymetrix Laboratories Points to Changing View of How Genome Works

...of the DNA sequence analyzed was transcribed; most sites of transcription were not located in areas associa...rays to map new human transcription factor binding sites ...

Placenta Is A Rich Source Of Blood Stem Cells

...stem when transplanted into an adult. Unlike other sites where blood stem cells are found during embryonic development, such as the liver, the stem cells in the placenta can increase in number without giving rise to mature, specialized cells. ''There must be something unique about the placenta that nurtur...

Nanogen Issued Patent for Electronic Microarray With Memory

...l is controlled at each of the NanoChip's 400 test sites to move and concentrate DNA or RNA, providing accuracy, speed and flexibility for developing molecular diagnostic tests. Storing critical voltage information allows for precise control of the biological molecules during analysis and increases data ma...

NIAID Initiates Trial of Experimental Avian Flu Vaccine

...enroll a total of 450 healthy adults. The clinical sites are part of the NIAID-sponsored Vaccine and Treatment Evaluation Units (VTEU). “While there have been relatively few cases worldwide of H5N1 avian influenza infection in humans, the public health community is concerned that the virus will develop th...

International trial of two microbicides begins

.... The first volunteers were enrolled this week at sites in Durban, South Africa, and at the University of ... in Philadelphia. Enrollment will begin shortly at sites in four additional African countries--Malawi, Tanzania, Zimbabwe and Zambia. Approximately 3,220 wom...

MetaChip provides quick, efficient toxicity screening of potential drugs

.... The first volunteers were enrolled this week at sites in Durban, South Africa, and at the University of ... in Philadelphia. Enrollment will begin shortly at sites in four additional African countries--Malawi, Tanzania, Zimbabwe and Zambia. Approximately 3,220 wom...

Scientists identify new model Of NK cell development

...the lymph nodes, but rather localized near special sites called parafollicular regions, rich in T cells and...t answers," says Caligiuri, "Finding these nursery sites of NK cells is just the first step. We feel this is the first solid evidence supporting a new model ...

In the migratory marathon, parasitized monarchs drop out early

...that do not migrate. Habitat loss at overwintering sites and climate warming trends, combined with an increase of tropical milkweed species in milder climates, could ultimately replace the large migratory populations with smaller remnants that breed year-round and do not migrate. Study results suggest tha...

Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments

...ents will be enrolled in the study at the 20 study sites across the country. The Genetic Angiogenic Stimulation Investigational Study (GENASIS) is funded by Corautus Genetics. More than 11 million people in the United States suffer from coronary artery disease. Many patients receive medications to increa...

Ophthalmologists Use Artificial Silicon Retina Microchip To Treat Vision Loss

...o, who oversees the three participating sites. The sites are Johns Hopkins School of Medicine, Baltimore, Emory University School of Medicine/Atlanta VA Medical Center and Rush. Pollack says the current protocol has been modified to reduce the likelihood of inadvertant scientific bias. "We operated on the...

Children's taste sensitivity and food choices influenced by taste gene

...S2R38 genotype: Type AA had two bitter-insensitive sites (alleles), type PP had two bitter-sensitive alleles, and type AP had one of each. To provide a behavioral measure of sensitivity to bitter taste, children ?who were between 5 and 10 years of age - and mothers categorized three concentrations of a bi...

Ophthalmologists implant five patients with artificial silicon retina microchip

...o, who oversees the three participating sites. The sites are Johns Hopkins School of Medicine, Baltimore, Emory University School of Medicine/Atlanta VA Medical Center and Rush. Pollack says the current protocol has been modified to reduce the likelihood of inadvertant scientific bias. "We operated on the...

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