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Tag: "single" at biology news

Inflammation may play role in metastasis of prostate cancer

... IkB kinasea (IKKa) turns down the expression of a single gene called Maspin, which has well-established anti-metastatic activity in breast and prostate cancers. They found that the production of Maspin is repressed by a series of events triggered by tumor inflammatory cells, with the result that prostate ...

Gene expression test reveals ER and HER-2 status of breast tumors

...est in an effort by the research team to develop a single test to quickly and efficiently determine the char... "This moves us closer to developing an integrated single genomic test that could estimate the risk of cancer relapse after surgery, determine the ER and HER2...

Scientists map key landmarks in human genome

...used gene microarrays to which DNA associated with single nucleosomes was added. The nucleosomal DNA was derived from several cancer cell lines including melanoma and breast cancer, as well as several normal human cell types. A critical component of the analysis involved processing the data using computatio...

No-scalpel vasectomies by skilled surgeons may speed recovery

...aller trial included 100 participants treated at a single site in Denmark. None of the eight doctors had substantial experience in the no-scalpel technique. Training was limited to an instructional video and one supervised procedure. Only one surgeon performed more than 10 no-scalpel vasectomies in the tria...

Scientists discover a new risk factor for Alzheimer's

...of Israeli Arabs. They tracked the SORL1 genes via single nucleotide polymorphisms, or SNPs, which are single-letter changes in a gene's sequence. They found that the Caucasians with Alzheimer's displayed a certain SNP signature at one end of the gene, while the African Americans, Hispanics, and Israeli Ara...

Birth rate, competition are major players in hominid extinctions

... modern humans suffered from the primate curses of single births widely spaced. For Neandertal, cultural adaptation was not sufficient to overcome and compete with modern humans, just as Paranthropus boisei could not compete with the likes of bush pigs and hyenas. " Can we, today, control our cultural beh...

Penn researchers replace organ in adult mice using 'single-parent' stem cells

... uniparental embryonic stem cells - created from a single donor's eggs or two sperm - and, for the first time, successfully used them to repopulate a damaged organ with healthy cells in adult mice. Their findings demonstrate that single-parent stem cells can proliferate normally in an adult organ and coul...

Susceptibility to Crohn's disease -- an important new clue

...nome-wide association study with more than 300,000 single nucleotide polymorphisms (SNPs) ?DNA sequence variations occurring when a single nucleotide in the genome differs between members of a species ?Cécile Libioulle et al. identified a ...

New sensor detects gaseous chemical weapon surrogates in 45 seconds

...ning forks, allowing simultaneous examination of a single sample at many infrared wavelengths. Nearly every molecule has unique optical properties at infrared wavelengths between three and 12 micrometers, and QCLs provide access to any wavelength in this region. "Because of this access and the fact that ...

Scientists uncover new target in cancer mutation puzzle

...eral mutations must arise and collaborate within a single cell. Ras and p53 mutations are particularly dangerous, implicated in colon, pancreas, lung and other cancers. Ras is part of a family that transmits signals controlling the way cells behave. Hyperactive Ras can lead to the uncontrolled growth of tum...

Largest genomic search finds genes that may contribute to autism

...oration to make progress. It is doubtful that any single laboratory could have come up with this kind of finding. This is just the beginning of the fruits from this collaboration." The Autism Genome Project used two techniques to examine the DNA of the nearly 1,200 families with a history of autism. Re...

Will the plague pathogen become resistant to antibiotics?

...sed against plague has been found so far in only a single case of the disease in Madagascar. But because the same ability is present in other kinds of bacteria from a broad range of livestock, antibiotic resistance could potentially spread to other Y. pestis and also other bacterial pathogens. In a paper pu...

Scientists discover new virus caused deaths of transplant recipients from single donor

...e transplant recipients who received organs from a single donor in Victoria, Australia. The previously unknown virus, which is related to lymphocytic choreomeningitis virus (LCMV), was found using rapid sequencing technology established by 454 Life Sciences and bioinformatics algorithms developed in the G...

Tiny clue reveals new path toward heart disease

...earchers focused on specific gene variants, called single nucleotide polymorphisms (SNPs), that occur when a single nucleotide building block in the long strand of DNA is altered. The researchers sought SNPs that occ...

Gene hunters close in on Lou Gehrig’s disease

...276 unrelated subjects with ALS. The 34 so-called single nucleotide polymorphisms, or SNPs, represent good candidate genes predisposing people to the non-inherited form of the fatal neurodegenerative disease. “Although we haven’t located the exact gene responsible for sporadic ALS, our results seriously...

Walking molecule now carries packages

...tels explained that using machines at the scale of single molecules will ultimate be the most efficient way to build objects or to deliver material. "It resembles the way nature does it: the molecule carrier transports carbon dioxide across a surface," he said. "In the human body, the molecule hemoglobin ...

MIT biologists solve vitamin puzzle

...enigma-until now. The researchers report that a single enzyme synthesizes the fragment, and they outline a novel reaction mechanism that requires cannibalization of another vitamin. The work, which has roots in an MIT undergraduate teaching laboratory, "completes a piece of our understanding of a proc...

Boosting brain power -- with chocolate

...eas of the brain in individuals who had consumed a single drink of flavanol-rich cocoa. The effect is linked to dilation of cerebral blood vessels, allowing more blood ?and therefore more oxygen ?to reach key areas of the brain. Flavanols are not only found in chocolate with a high cocoa content ?they ar...

'Ancestral eve' was mother of all tooth decay

...hosts in a clear line that can be traced back to a single common ancestor who lived in Africa between 100,00...e also employed to trace human evolution back to a single common African ancestor, known as "ancestral Eve." "As humans migrated around the world and evo...

Scientists map air pollution using corn grown in US fields

... annual plant, all of its carbon is derived from a single growing season. The scientists avoided pollution point sources such as highways and power plants to allow for mapping of regional patterns across different states. Back in the laboratory, the scientists dried samples of corn leaves and husks, then co...

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