Sickle cell disease corrected in human models using stem cell-based gene therapy
...lobin. "This proved our hypothesis that you can simultaneously add one function and delete another in the same cell and obtain synergistic genetic modifications within a single cell," said Selda Samakoglu, PhD, a member of Dr. Sadelain's laboratory and the study's first author. "In this case, we used the techniq...Magnetic probe successfully tracks implanted cells in cancer patients
...ctive tracking method and provided anatomic detail simultaneously -- structural detail not possible by tracking radioactivity. "On the MR images, we can see the lymph nodes, and we can see the magnetically labeled dendritic cells, and we can tell very clearly whether they are in the same place," says the study's ...DNA self-assembly used to mass-produce patterned nanostructures
...A building blocks that assemble themselves, we can simultaneously make trillions of copies of a desired structure." To create the tiny DNA grids, LaBean, Dwyer and their colleagues began with tiny building blocks they called "tiles." Each tile was made up of strands of DNA bent like pipe cleaners into the shape of...Double trouble: Cells with duplicate genomes can trigger tumors
...ancer setting." A companion paper being published simultaneously in Nature by Randy King and colleagues at Harvard Medical School reports that tetraploid cells may arise more frequently than had been thought. According to Pellman, the instability of tetraploid cells may have played a role in evolution, because ma...New possibilities for flu antiviral and vaccine research emerge from 'Spanish flu' virus
...uence, whose final three genes are being published simultaneously this week in Nature, Tumpey's group created a live virus with all eight of the Spanish flu viral genes. The genome sequence information was recovered in fragments from lung autopsy materials and lung tissues from a flu victim who was buried in the Al...Older female fish prefer imperfect male mates, study finds
...nequal number of bars on each side. The animations simultaneously were projected on opposite sides of a tank, and researchers measured the time the female spent with each animation. While younger and smaller females still showed a preference for the symmetrical male, older and larger females increasingly preferred ...A New Era of Hope for the World's Most Neglected Diseases
...rmectin—in a single delivery mechanism in order to simultaneously target lymphatic filariasis, onchocerciasis, soil-transmitted helminthiases, schistosomiasis, and trachoma (Lancet 365: 1029?030). Thirdly, and perhaps most importantly, the neglected diseases have at long last caught the attention of the internatio...Sea slug mixes chemical defense before firing at predators
...cuous precursors separately and then releases them simultaneously into its mantle cavity at the precise time when they are needed," explained Derby. "This mechanism insures the secretion's potency against attacking predators to enable sea slugs to escape." Aplysia employs a variety of mechanisms to defend against ...Bees solve complex colour puzzles
...ility to find the same flowers in scenes that were simultaneously illuminated by four differently coloured lights - UV-yellow, blue, yellow and green. To solve this puzzle, the bees had to effectively segment the scene into its different regions of illumination, and then find the correct flowers within each region....New maps reveal true extent of human footprint on Earth
... unprecedented Internet-based data bank that would simultaneously draw on the knowledge of global scientists, local environmentalists and everyday citizens. Adds Foley: "[The Collaboratory] will truly be a brave new experiment that effectively bridges science, decision-making and real-world environmental practice -...UCSD study finds anthrax toxins also harmful to fruit flies
... have multiple host target proteins may be used to simultaneously reduce or eliminate the activities of several related proteins that perform overlapping functions in other diseases or biological processes. Such experimental tools could accelerate progress in various areas of biomedical research. Guichard first c...3D ultrasound device poised to advance minimally invasive surgery
...ssue in three perpendicular cross-sectional slices simultaneously or in the same way a camera would see it ? except that a camera can't see through blood and tissue." The technology has yet to be tested in human patients, but its success in dogs makes it ready for clinical trials, according to the researchers. E...Rare Tibetan antelope listed as endangered
...ssue in three perpendicular cross-sectional slices simultaneously or in the same way a camera would see it ? except that a camera can't see through blood and tissue." The technology has yet to be tested in human patients, but its success in dogs makes it ready for clinical trials, according to the researchers. E...'Virus chip' detects new virus in prostate tumors
... power of the virus chip resides in its ability to simultaneously screen for all viruses, without preconceptions or bias," said Joe DeRisi, PhD, a Howard Hughes Medical Institute (HHMI) investigator at UCSF who developed the chip with colleagues in his lab. "In the case of these prostate tissues, no one would have ...Simple idea to dramatically improve dengue vaccinations
... very simple solution ?injecting the four vaccines simultaneously at different locations on the body. A mosquito-bo...d polytopic vaccination ?giving different vaccines simultaneously at different locations on the body ?could help overcome immunodominance by taking advantage of the r...Horse antibodies against the bird flu virus H5N1 are effective as treatment in mice
...dney cells in vitro with a lethal dose of H5N1 and simultaneously exposed the cells to horse antibodies against H5N1...1 protected cells against H5N1 in vitro ?the cells simultaneously infected with H5N1 and exposed to horse antibodies did not die. Lu et al. then injected horse anti...Tastier tomatoes in the future?
... biological samples. It can be used to quickly and simultaneously look into a fruit's amino acids, organic acids, sugar and vitamins. Dr. Alisdair Fernie, head of the Institute's "Central Metabolism" research group, discovered that there were 880 variations in the content composition of descendants produced by cro...Flesh-eating bacteria escape body's safety net
...oduced by certain strains of Strep bacteria, while simultaneously confirming just how important neutrophil DNA nets are to our normal immune defense," said Buchanan. Recognizing the critical role played by the DNA-degrading enzyme in progression of Strep disease, the UCSD researchers examined whether it could repr...Red Tide causes sea turtle die-off in El Salvador
...t-mortem examinations on one of the turtles, while simultaneously training Salvadorian colleagues in tissue collection techniques. Samples were then sent to Florida's Fish and Wildlife Research Institute, where technicians then found high levels of saxitoxin, which affects the nervous systems of humans and animals ...Study suggests that publicly available genome data may contain small but significant errors
...array technique that involves testing many samples simultaneously and which can be used to assemble physical maps and validate genomic sequence assemblies. The findings appear in the latest issue of the Journal of Computational Biology. The research was conducted by Joseph West, John Healy, and Michael Wigler ...