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Tag: "simplex" at biology news

Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model

...d (neurturin) into a genetically engineered herpes simplex virus (HSV). They then injected either of the recombinant viruses into the damaged cavernous nerve of rats. GDNF is an important nerve growth promoter and has been shown in other studies to contribute to survival and regeneration of penile nerves. Ne...

New vaccine prevents CMV infection and disease in mice

...other herpes viruses such as chicken pox or herpes simplex – have the same or very similar sequence, structure and function whether in human or mouse viruses, and present a novel target for the host’s T-cells to muster forces and attack the virus. Secondly, the vaccine also contains a “boost” from an inactiv...

'Insulator' helps silence genes in dormant herpes virus

...out of painful cold sores brought on by the Herpes simplex virus 1, also known as HSV-1. After the initial infection, the virus usually remains in the body, hiding out in nearby nerve cells where the victim's immune defenses cannot reach it, causing no symptoms at all. In order to escape detection by the bo...

Researchers wake up viruses inside tumors to image and then destroy cancers

...ts "sister" kinase, the one produced by the herpes simplex virus, can be imaged by an injected radiolabeled c...have always had to infect cells with active herpes simplex virus so that they can replicate, express TK, and only then could we use the FIAU tracer to make the...

Cold sore virus might play role in Alzheimer's disease

...zheimer's disease, with the form of herpes ?herpes simplex 1 or HSV ?that infects more than 80 percent of Ame...different phases of the virus's life cycle. Herpes simplex is a chronic infection that lives in a person for a lifetime, periodically flaring up in a "lytic" p...

New drug blocks influenza, including bird flu virus

... found by Brandt and his colleagues to stop herpes simplex virus infection. ...

Research holds promise for herpes vaccine

...genital herpes and other diseases caused by herpes simplex viruses. In a study published earlier this year ...accinated with a live, genetically-modified herpes simplex virus type 1 (HSV-1) showed no signs of disease 30 days after being exposed to a particularly lethal...

Inheriting a tendency to brain infection

...single gene that predisposes individuals to herpes simplex encephalitis, an infectious disease that tends to ... eight out of 10 adults are infected by the herpes simplex virus. For most, the worst symptom is a cold sore, but in some individuals, the virus causes inflamm...

Innovative method for creating a human cytomegalovirus vaccine outlined

...the herpes virus family, which includes the herpes simplex viruses, the viruses that cause chicken pox (varicella-zoster virus), and infectious mononucleosis (Epstein-Barr virus.) Infectious transmission is via body fluids. ...

Infected for life

..., Professor of Microbiology, has found that herpes simplex virus-1 (HSV-1), the virus that causes cold sores and ocular keratitis, produces an miRNA molecule. This miRNA is encoded by the Latency-Associated Transcript gene (LAT) in the viral genome and works through a process called RNA interference to preve...

Researchers find 'secret weapon' used by SARS virus

...virus is known to break down messenger RNA: herpes simplex virus (HSV). Makino credits lead author Wataru Kamitani, a UTMB postdoctoral research fellow, with noticing that the nsp1 protein had an unexpected effect while he was investigating a different set of SARS coronavirus proteins. "He found this supp...

Mice lacking key immune component still control chronic viral infections

...ect humans include the alpha herpes viruses herpes simplex virus 1 and 2, which cause cold sores and genital herpes, and varicella zoster virus, which causes chickenpox. Infection with gamma herpes viruses such as EBV and KSHV increases the risk of some cancers, especially in persons with weakened immune sys...

Knowledge of infection may prevent spread of herpes virus

...ion would lead to decreased transmission of herpes simplex virus (HSV) to others. But Anna Wald, MD, MPH, and colleagues at the University of Washington and the Fred Hutchison Cancer Research Center in Seattle studied 199 patients with newly acquired genital HSV-2 infection and found that patients were abou...

Unraveling the viral mechanism

...ucturally similar although smaller than the herpes simplex virus, which causes cold sores and related infections. That means it should be possible to use these tools to understand better how this and similar viruses infect nerve cells and, some day, interrupt that disease process. The advance occurred becau...

Cyclosporine inhibits hepatitis C virus in vitro

...wn to have anti-viral activity against HIV, herpes simplex and vaccinia virus, leading researchers to speculate it might also inhibit hepatitis C virus. To examine this hypothesis, they analyzed the impact of the drug in a liver transplant population. They also studied its effect on hepatitis C in vitro. Fo...

Scientists use gene transfer technology and common virus to block neuropathic pain

...to their success is based on a virus called herpes simplex or HSV ?the same virus that causes cold sores and ...emoving genes that make it possible for the herpes simplex virus to infect a human host, VA/U-M scientists use it as a carrier to deliver GAD to the nucleus of...

Scientists use gene transfer technology and common virus to block neuropathic pain in animals

...to their success is based on a virus called herpes simplex or HSV ?the same virus that causes cold sores and ...emoving genes that make it possible for the herpes simplex virus to infect a human host, VA/U-M scientists use it as a carrier to deliver GAD to the nucleus of...

High rates of sexually transmitted infections found in young drug users

... and other institutions found high rates of herpes simplex virus 2 and syphilis among young drug users in Bal...of Public Health. The researchers examined herpes simplex virus 2 and syphilis test results in 543 heroin, cocaine and crack users from Baltimore, Md., aged 1...

Achilles heel of the herpes virus possibly found

...scientists haven't fully understood how the herpes simplex virus (HSV) manages to do all of this. And that ha...eam's reports about a possible 'key' on the herpes simplex virus surface that may match the 'lock' found by the U-M team. The Italian team has identified a reg...

Turning viruses into allies against cancer

... virus that causes measles and another, the herpes simplex virus, responsible for those lip blisters known as...ariety of Tumors: Abstract 5292 A modified herpes simplex virus, built with a potent immune stimulant to thwart the spread of cancer cells, is being tested in...

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