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Tag: "silent" at biology news

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...Unlike most genes, the copy of IGF2 that should be silent depends only on which parent it came from, a situation called genomic imprinting. For IGF2, the copy inherited from the mother is always supposed to be turned off. In the mice and in some people, however, cells lack the epigenetic "marks" that sit o...

Researchers trace evolution to relatively simple genetic changes

...n fish remain well-armored. "But they do have this silent gene that allows this alternative form to emerge if the fish colonize a new freshwater location." Also, comparing what happens to the ectodysplasin signaling molecule when its gene is mutated in humans, and in fish, shows a major difference. The hum...

Octopuses occasionally stroll around on two arms, UC Berkeley biologists report

...n fish remain well-armored. "But they do have this silent gene that allows this alternative form to emerge if the fish colonize a new freshwater location." Also, comparing what happens to the ectodysplasin signaling molecule when its gene is mutated in humans, and in fish, shows a major difference. The hum...

New RNA polymerase discovered in plants

...the Arabidopsis genome, principally in keeping the silent DNA silent," Pikaard said. "Plants can get by without Pol IV, whereas they can't do without the other three. We don't see anything obviously like Pol IV in any other genome, but it's possible it might have been overlooked." While Pikaard and his col...

50-year-old Mystery Solved: Protein Tags Regulate Key Ion Channel

...ave yet to reveal their function because they were silent like K2P1." Other membrane proteins key to biology, like transporters and hormone receptors, may also be controlled by SUMO since the binding site is present in those proteins although not yet proven to operate. "Cells are fastidious in the way the...

Brain May Be Less Plastic Than Hoped

...the motor and visual cortex after these areas fell silent from lack of sensory input due to injury. This led...blind spot would have shrunk.?Instead, though, the silent region remained the same size each time. The neurons surrounding it did not reach out to fill it in....

Most common lung cancers may begin in newly discovered cells

...l and experimental therapies. The mouse carries a silent genetic mutation of an oncogene known as K-ras, which is found in about one-third of all tested non-small cell lung cancers in people. A specially designed virus can activate the mutation in only a few cells. The mouse is known as a conditional mutan...

Research casts doubt on circulating stem cells

... the defective muscle, we suspect that they remain silent and cannot set off the hoped-for 'muscle programme'." In other words, the bone marrow-derived cells are not converted into functioning muscle fibre. The myth of a circulating jack of all trades The reason is probably that in nearly all cells releas...

Studies on human genome variation provide insight into disease

.... The real disease-causing culprits can have many silent partners. We need to know the relationships of all these partners to focus on real disease mutations and to minimize attention on the innocent gene variants that colour the humanity of life." Contact: Lon R. Cardon, Ph.D. Professor of Bio...

Housecat-sized Siberian tiger cubs get collared

.... The real disease-causing culprits can have many silent partners. We need to know the relationships of all these partners to focus on real disease mutations and to minimize attention on the innocent gene variants that colour the humanity of life." Contact: Lon R. Cardon, Ph.D. Professor of Bio...

There's something fishy about human brain evolution

...The genetic possibility was there, but it remained silent until it was catalyzed by this shore-based diet." Dr. Cunnane acknowledges that for the past 20 years he's been swimming upstream when it comes to convincing anthropologists of his position, especially that initial hominid brain expansion happened b...

Cloned stem cells prove identical to fertilized stem cells

...nk measured which genes were active and which were silent in both kinds of cells. To ensure the accuracy of his results, he compared five lines of cloned stem cells with five fertilization-derived stem cell lines. "The results are very clear," says Brambrink. "If a gene is active in fertilized stem cells,...

UC Riverside psychologist explores human perception, finds 'wow factor'

... understanding of how human hearing is affected by silent objects. His projects are all motivated by theoretical questions rather than a quest for a particular application, Rosenblum said, but real-world considerations are important. "We discuss practical applications in papers so engineers can use them in...

What's shaped like a pear and has 2 genomes? Check the pond

...ed for sex and reproduction, remaining genetically silent during growth. Inside the second, working nucleus is the "macronuclear" genome, which expresses genes that govern behavior. The current study sequenced the macronuclear genome, an impressively packaged bunch of coding genes, free of so-called junk...

Bird flu study highlights need to vaccinate flocks effectively

... than 95 per cent would be needed to guard against silent spread. The study, funded by the Department of E..., suggests that the most effective way of tackling silent spread of the disease would be to place unvaccinated 'sentinel' birds in poultry flocks. By monitor...

Loosen up, DNA: Leukemia gene changes genetic packaging

...based on where the gene was inserted ?the gene was silent when expected, producing flies with white eyes, an...s that JAK/STAT was able to open up the previously silent part of the genome, somehow turning on the red-eye gene by changing the gene's packaging. Genes that...

Researcher studies, treats military with 'silent disease'

...eely through the liver. The disease has earned its silent reputation because 80 percent of the people who have it have no symptoms. While working at her clinic at the military hospital, Sjogren noted that at least half of her patients tested positive for the hepatitis C virus. She then started wondering ab...

Prion find points way to test for human 'mad cow' disease

...t time we have detected prions in what we call the silent phase of infection, which in humans can last up to 40 years," said Soto, senior author of the Science paper. "The concern is that if many people are incubating the disease silently, then secondary transmission from human to human by blood transfusio...

Orange, grapefruit juice for breakfast builds bones in rats

...ter at Texas A&M in College Station. "It's a silent disease of aging. But if we can maintain our bone strength, maybe we'll be able to prevent it," Patil noted. For the study, 36 males rats were included for two months in the lab of Dr. Farzad Deyhim, professor of human and animal nutrition at Texas ...

Researchers find protein that silences genes

...and colleagues found that they could switch on the silent genes using chemicals that inhibit either DNA meth...inated nucleolar dominance, such that the normally silent genes were now turned on. To find out where HDA6 is located in the cell, the group then geneticall...

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