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Tag: "silencing" at biology news

Novel antiviral technology inhibits RSV infection in mice

...antiviral treatment combiningnanoparticle and gene silencing technologies thwarts attacks ofrespiratory syncytial virus (RSV) -- a virus associated with severebronchitis and asthma, an animal study by University of South Floridaresearchers found. The study was reported in the January 2005 issue ofthe journal N...

Enzyme shown to help protect genomic stability

... Scientists believe one reason for this broad gene silencing is the vital need for genomic stability, for prote... this reason, insights into the mechanisms of gene silencing could provide important guideposts for new approaches to retarding aging or treating cancer. Now, a...

TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

...hey succeed in eliminating p53 activity, in effect silencing the command to commit suicide. This situation occurs when increased TEL2 activity reduces the cell's ability to trigger apoptosis in response to relentless prodding by MYC to keep multiplying. As the process of apoptosis becomes sluggish, the populat...

Variation in women's X chromosomes may explain differences among individuals, between sexes

...that the inactivation process resulted in complete silencing of the genes on the second X chromosome, Willard said, in order to leave both sexes with the same activity level, or dosage, of the genes encoded by the X chromosome. Scientists had also implicitly assumed that the X chromosomes in all women would be...

50-year-old Mystery Solved: Protein Tags Regulate Key Ion Channel

...." The problem was that some hidden mechanism was silencing the channel, plugging the pipeline, but no known method of channel regulation seemed to be involved. Goldstein and colleagues began to suspect sumoylation [SUE-mow-e-LAY-shun]. In this process, an enzyme attaches a small peptide called SUMO (for sma...

UCSD-Salk Team Show Protein’s Gene-Silencing Role In Development of Nervous System

...uired for maintenance of neural stem cells and for silencing expression of neuronal genes in non-nervous system tissues. Published in the January 28, 2005 issue of the journal Science, the study found that the phosphatases, called small carboxyl-terminal domain phosphatases (SCPs) are expressed in almost all ...

Silence the gene, save the cell: RNA interference as promising therapy for ALS

...anced online publication March 13. In addition to silencing the mutated gene that causes ALS, the EPFL researc... delivered and the protein never gets made. "Gene silencing is an example of using "molecular scissors" at its most advanced level," Raoul explains. Raoul and ...

Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma

A novel delivery system that transports gene silencing nanoparticles into tumor cells has been shown to inhibit Ewing's sarcoma in an animal model of the disease. In this classic "Trojan horse" approach, a protein called transferrin that normally delivers iron into cells is modified to also smuggle into...

Protein helps regulate the genes of embryonic stem cells

...mpact on gene expression - either by activating or silencing a gene. "Diversity is determined by different types of chemical modifications and also by the number of modifications," Montgomery said. "And those modifications are the unit of epigenetic information, just as the DNA sequence is the unit of genetic...

Ancient immune defense mechanism is no match for HIV-1

...dy is published in the May issue of Immunity. RNA silencing is a type of natural immune defense in which seque...ces, resulting in the production of an RNA-induced silencing complex (RISC). RISC can specifically identify and degrade complementary target RNA. This process is...

Newly discovered protein an important tool for sleeping sickness research

...thyluracil) may play an important role in the gene silencing process behind antigenic variation. With the goal ...on. If base J does indeed play a role in the gene silencing that enables the trypanosome to change its antigen coating, the discovery of JBP2 may one day enable...

U. Iowa researchers improve Huntington's disease symptoms in mice

...r regarding whether the normal gene is critical by silencing the normal gene in adult brain cells of HD models. Despite the remaining hurdles, Davidson is optimistic about the potential of RNAi to treat HD and similar neurodegenerative diseases. "If the benefit is confirmed in other mouse models of Huntingto...

Breakthrough System for Understanding Ocean Plant Life Announced

...thyluracil) may play an important role in the gene silencing process behind antigenic variation. With the goal ...on. If base J does indeed play a role in the gene silencing that enables the trypanosome to change its antigen coating, the discovery of JBP2 may one day enable...

Gene silencing technique offers new strategy for treating, curing disease

...tly, the researchers also employed RNA itself as a silencing agent. Previous work by other scientists had shown that RNA might be able to target chromosomal DNA, so once Dr. Corey and his team saw that PNAs were working, they decided to try RNA as well. "The RNA is more important because it may reflect the bo...

Molecular steps involved in the creation of gene-silencing microRNAs identified

... directly through to the molecules responsible for silencing genes," says Ramin Shiekhattar, Ph.D., an associate professor at Wistar and senior author on both Nature studies. "The miRNAs provide specificity for those molecules, which do the actual work of gene silencing." Intriguingly, the research also links...

Montreal researchers probe the genetic basis of memory

... molecules that facilitate memory storage, and the silencing of proteins such as GCN2 that inhibit memory storage." Although research on humans is still a distant possibility, the scientists believe their discovery may hold promise in the treatment of a variety of illnesses linked to memory. "The discovery of...

Scientists find microRNAs regulate plant development

...city to a protein complex known as the RNA-induced silencing complex. Within the complex, microRNAs are thought...AUTE1 (AGO1), a major component of the RNA-induced silencing complex in Arabidopsis. There are many AGO1-like proteins in animals and other eukaryotes as well, i...

Researchers feed tiny pills of RNA to planarians to identify genes essential for regeneration

...s makes it easier to identify a gene's function by silencing it and will help how researchers target their efforts on equivalent genes in mice or zebrafish, for example. * It is inexpensive to study. Now that Sánchez Alvarado and his colleagues have opened the door to understanding regeneration by identif...

How cell suicide protects plants from infection

...ess. Dinesh-Kumar first developed a technique for silencing or inactivating plant genes -- a technique that is now used by several research groups. His group studies the interaction between plants and viruses using tobacco as a model system. They identified and silenced a "pro-survival" gene, BECLIN-1, that ...

Virus uses tiny RNA to evade the immune system

...rs to cloak itself with a recently discovered gene silencing device to evade detection and destruction by immun...may be the first to show how a virus uses the gene silencing machinery for its own infectious purposes. In people, plants, and worms, hundreds of tiny RNA molec...

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