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Tag: "silences" at biology news

Salk scientists hammer out a pathway that promotes muscle cell survival in mice

...scle cells grown in the lab using a technique that silences gene expression. Less SIK1 activity resulted in less phosphorylated HDAC. With the unphosphorylated HDAC brake now firmly in place, expression of muscle-specific target genes was also reduced. Conversely, when the researchers boosted SIK1 levels or i...

Detailed 3-D image catches a key regulator of neural stem cell differentiation in action

...ar and Molecular Medicine at UCSD, found that Scp1 silences neuron-specific genes in non-neuronal cells last year. "Having a specific inhibitor would give us a lot of insight into the development of the fetal nervous system and would allow us to chemically push embryonic stem cells to acquire a neuronal fate ...

Interfering RNA silences genes in 'slippery' immune cells

...nes by studying what happens when RNAi temporarily silences them--a process calling "knocking down" the gene. The research by Dr. Finkel's team aims to extend RNAi to a wider pool of researchers by making the technique less expensive and more widely available, as well as adapting it to T cells, a cell type p...

In a technical tour de force, Salk scientists take a global view of the epigenome

...d. The investigators also found that methylation silences transposons, so-called "jumping genes," which can wreak genomic havoc by hopping about the chromosomes. In the words of Ecker, undermethylated transposons "just go wild," suggesting that mother nature keeps transposons in time-out by covering them wi...

MicroRNA may have fail-safe role in limb development

...ty in chicken embryos and in mice, finding miR-196 silences a chemical important for transferring information from DNA to RNA within a cell - a transcription factor. "It's turning off a transcription factor in the hindlimb that is important for forelimb development," Harfe said. "But it still doesn't explain...

Researchers feed tiny pills of RNA to planarians to identify genes essential for regeneration

...ed bacteria to synthesize double-stranded RNA that silences planarian genes. The bacteria effectively become tiny pills-five to 10 microns across-that now can be mixed into planarian food. When Sánchez Alvarado and his associates fed the worms dinner, the RNA diffused throughout their bodies. Sánchez Alvarad...

Used in a new way, RNA interference permanently silences key breast cancer gene

...east cancer development. The technique permanently silences activated STAT3, a crucial gene found in some human breast tumors, thus reducing the cancer's ability to become invasive. The study, presented at the annual meeting of the American Association for Cancer Research (AACR), used a modified form of RNAi...

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