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Tag: "silenced" at biology news

Researchers discover inherited mutation for leukemia

... might contribute to cancer even when they are not silenced entirely. "This inherited change is remarkably...e new field of epigenetics, which identifies genes silenced by faulty DNA methylation, says Christoph Plass, professor of molecular virology, immunology and med...

Research team identifies new Alzheimer's gene

...ain cells containing tangles. When the researchers silenced GAB2 in preliminary studies it increased a molecular process thought to play an important role in the development of tangles. Based on these findings, the researchers hypothesize that GAB2 might function under normal conditions to compensate for the ...

Turn-ons and turn-offs for neurons

...during early mouse development become functionally silenced in the adult brain. Intriguingly, Hasan and collea...tors which facilitate “un-silencing” of previously silenced genes. These findings have important implications in experimental research that makes use of reversi...

'Insulator' helps silence genes in dormant herpes virus

... of the genome contain modifications indicative of silenced chromatin. The patterns found resemble well-studied regions where insulators are found in both yeast and chicken, namely the yeast mating loci and chicken globin locus. To see if insulators play a role in silencing viral genes during the latent ph...

Newly identified mechanism for silencing genes points to possible anti-cancer strategies

...cell at a given time. The remaining 90 percent are silenced by a various mechanisms that act to interfere with gene transcription into messenger RNA or translation of messenger RNA into protein. In a new study published online May 16 in the journal Nature, a team of scientists at The Wistar Institute and t...

Leukemia drug turns mini-molecules up, cancer genes down

..., and through them regulates genes that need to be silenced for the cell to differentiate." ...

NIAID expands capability for influenza research and surveillance

... researchers will examine how human genes might be silenced to decrease or eliminate flu infections; identify new targets for antiviral medicines; and evaluate flu transmission between patients and physicians in the hospital emergency room setting. Emory will also offer a training program for postdoctoral fel...

A genetic 'gang of 4' drives spread of breast cancer

...n, the lung." To test this idea, the researchers silenced various combinations of the four genes in human breast cancer cells that had metastasized to the lung, and then tested these cells in mice. To silence the four genes, the scientists used a technique called RNA interference, in which RNA molecules are...

Trusting your instincts leads you to the right answer

... conflict and in this case our instincts are often silenced by our reasoning conscious mind. Participants would have improved their performance if they had been able to switch off their higher-level cognition by, for example, acting quickly." Tracking participants' eye movements, the team controlled the tim...

Regulating the nuclear architecture of the cell

...disabled by RNA interference. Transposons are also silenced by accumulating in the transcriptionally-silent heterochromatin, which Karpen calls "a graveyard of transposons." While the gene for the Dicer-2 enzyme, dcr-2, is a key player in the RNAi pathway, the RNAi process also targets H3K9 methylation. S...

Key to acute lung injury lies in Ang2 protein

... which the Ang2 gene was genetically eliminated or silenced lived longer and had evidence of decreased lung injury compared to mice in which the gene and protein were intact. Levels of the Ang2 protein were then measured in the blood and lung fluid of adult patients and babies with acute lung damage and pu...

Newly discovered behavior in cancer cells signals dangerous metastasis

...ia-Blanco said. "A particular exon, FGFR2 IIIc, is silenced in mesenchymal cells but is active in epithelial cells. "We can visualize the genes as they are dynamically changing," he said. "We can define the cell types by observing their splicing patterns." According to Garcia-Blanco, the cellular switch tha...

A simple feedback resistor switch keeps latent HIV from awakening

...ctly regulated and viral gene expression perfectly silenced during latency, this system would be foolproof. But this is almost never the case--there is always noise and always the potential for some low level of erroneous transcription. This poses a problem for the virus--how does it prevent stray transcripti...

Parental genes do what's best for baby

...nt’s copy; the spare copy from the other parent is silenced by a chemical stamp.? The concept of imprinting has long puzzled scientists as it appears to undermine the natural benefits organisms gain from inheriting two sets of genes. If one copy of a gene is damaged, for instance, then the second copy ca...

Researchers find protein that silences genes

... that understanding how some genes are selectively silenced and how silenced alleles can be turned on again may someday have practical benefits. For instance, tumor suppressor ...

Activation of microRNA inhibits cancer gene in human cancer cells

...gs, can reactivate genes that have been abnormally silenced in cancer cells. It is conceivable that these processes may also regulate expression of some RNAs. MicroRNA (miRNA) is small and noncoding RNA that can regulate gene expression by inhibiting protein translation. Recent research has implicated miRNA...

Loosen up, DNA: Leukemia gene changes genetic packaging

...ackaging. Genes that were previously turned off or silenced were turned on once JAK/STAT changed the genetic p...he ability to turn on sets of genes that have been silenced in this way. Scientists have thought that JAK/STAT works by directly turning on genes that make tu...

Pathway toward gene silencing described in plants

...cause understanding how some genes are selectively silenced and how silenced alleles can be turned on again may someday have practical benefits. For instance, tumor suppressor ...

Genetic snooze button governs timing of spring flowers

...old triggered a molecular process that effectively silenced the genes that repress flowering. Another processes known as bud dormancy, which is similar to vernalization, occurs in many plants that grow in temperate climates. "Bud dormancy is not broken until the plant has 'counted' a sufficient number of da...

Silence of the amoebae

...e scientists now plan to test the ability of these silenced amoebae to serve as a live vaccine by evoking an intestinal immune response. If successful, it may put an end to amoebic diseases that claim the lives of thousands yearly and afflict millions more....

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