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Tag: "silence" at biology news

Scientists identify genetic pathways essential to RNA interference

... could be synthesized quickly and inexpensively to silence a single gene. Promising targets could include viruses like HIV and hepatitis C or cancer-causing oncogenes. An RNAi-based treatment for age-related macular degeneration is already in clinical trials." Ruvkun is a professor of Genetics at Harvard Med...

UCSD-Salk Team Show Protein’s Gene-Silencing Role In Development of Nervous System

...CSD professor of medicine. The ability of SCPs to silence genes was first shown by Gill and his post-doctoral fellow Michele Yeo, Ph.D., in an April 28, 2003 study published in the Journal of Biological Chemistry. Yeo is co-first author of the new study in Science, along with Soo-Kyung Lee, Ph.D., a post-do...

Silence the gene, save the cell: RNA interference as promising therapy for ALS

...d have used RNA interference in transgenic mice to silence a mutated gene that causes inherited cases of amyt...f a disease of the nervous system in which you can silence the gene and at the same time produce another normal form of the protein," notes Patrick Aebischer, ...

Scientists identify genetic pathways essential to RNA interference

... could be synthesized quickly and inexpensively to silence a single gene. Promising targets could include viruses like HIV and hepatitis C or cancer-causing oncogenes. An RNAi-based treatment for age-related macular degeneration is already in clinical trials." Ruvkun is a professor of Genetics at Harvard Med...

Used in a new way, RNA interference permanently silences key breast cancer gene

...r Research (AACR), used a modified form of RNAi to silence STAT3 in a permanent way. Typically, only a transi...ble to use RNAi in more than just experiments that silence genes temporarily," says the study's principal investigator, Ralph Arlinghaus, Ph.D., a professor an...

Ancient immune defense mechanism is no match for HIV-1

...rocess is known as RNA interference (RNAi) and can silence the ability of a virus to successfully reproduce itself. Although this mechanism has been artificially manipulated to selectively inhibit specific genes in mammalian cells, it was not known whether mammalian viruses naturally elicit this type of immu...

U. Iowa researchers improve Huntington's disease symptoms in mice

...Ai molecule used in Davidson's current study would silence both the mutant and the normal gene. So, an important question that still needs to be addressed is whether adult neurons can tolerate and benefit from a partial reduction of both the toxic and the normal protein. If the normal protein is critical, th...

Speak up: Louder neurons form more connections

...ce through another molecular twist. She managed to silence some neurons near the green, quietly-firing cells. When she did that, the green cells were able to compete successfully and formed longer, more complex arbors. Although this work specifically examined the brains of fish, Smith said the same rules li...

Confirmation of human protein interaction data by human expression data

...ce through another molecular twist. She managed to silence some neurons near the green, quietly-firing cells. When she did that, the green cells were able to compete successfully and formed longer, more complex arbors. Although this work specifically examined the brains of fish, Smith said the same rules li...

Researchers feed tiny pills of RNA to planarians to identify genes essential for regeneration

...irst large-scale use of RNA interference (RNAi) to silence planarian genes to identify their role in the worm's biology, according to Alejandro Sánchez Alvarado, Ph.D., principal investigator and U medical school associate professor of neurobiology and anatomy. The U team's work shows that planarian genes ca...

Missing Receptor Molecule Causes Tumor Growth

... Methylation is indeed a common way in which cells silence genes, but in the affected tumor cells, it obviously happens at the wrong time. To conclude their research, Prof. Krainer and his colleagues retested their findings: Their results were confirmed by testing 36 different tumor tissues taken directly f...

Nanoparticles carry cancer-killing drugs into tumor cells

... Methylation is indeed a common way in which cells silence genes, but in the affected tumor cells, it obviously happens at the wrong time. To conclude their research, Prof. Krainer and his colleagues retested their findings: Their results were confirmed by testing 36 different tumor tissues taken directly f...

Hunt for human genes involved in cell division under way

...itutes throughout Europe, the EMBL scientists will silence all human genes, one-by-one, to find those involve...y synthesized RNA molecules are used to target and silence each human gene. About 22,000 genes will be suppressed and their impact on cell division monitored b...

Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models

... their study, the researchers used gene therapy to silence a normally functioning gene. Exploiting a mechanism called RNA interference, they were able to turn down the gene that helps produce the characteristic amyloid plaques that are one of the hallmarks of Alzheimer's disease. "Within a month of treatmen...

Virus uses tiny RNA to evade the immune system

...nts, and worms, hundreds of tiny RNA molecules can silence specific genes by interfering with larger messenger RNAs (mRNAs). That interference prevents mRNAs from making proteins. Scientists do not know which genes are hushed by the microRNAs in people, but the new study bolsters growing evidence that the li...

Micro RNAs play role in egg making

...is, the process by which females make eggs. MiRNAs silence genes by binding to genetic elements called messenger RNA and preventing them from making new proteins -- the molecules primarily responsible for cell activities. While previous research has identified some miRNA targets, investigators haven't yet s...

HIV accessory protein disables host immunity via receptor-protein intermediary

...ers used an siRNA, a short sequence of RNA used to silence gene expression, to completely destroy expression of the glucocorticoid receptor protein. When the researchers kept the glucocorticoid receptor protein from being made, Vpr did not kill host cells. "This indicated that glucocorticoid receptor funct...

Researchers unlock how cells determine their functions

...rs, researchers have focused on how noncoding RNAs silence genes," said Anthony Carter, of the National Institute of General Medical Sciences, which partially funded the research. "Dr. Sauer's work has revealed that noncoding RNAs have a broader range of functions than was previously known, and suggests a mo...

New RNAi tools enable systematic studies of gene function

...y of an extensive library of molecular reagents to silence most human and mouse genes. As described in the March 24 issue of Cell, this library consists of small RNA molecules that can switch off genes individually, allowing the user to dissect the genetic underpinnings of normal biology and disease. These ...

Tool developed to silence genes in specific tissues using RNAi

...developed a simple way to use the RNAi approach to silence a selected gene in a specific tissue in a mouse to...cells that ultimately become sperm. Using RNAi to silence WT1, therefore, led to the discovery that WT1 is the first transcription factor shown to regulate th...

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