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Tag: "signatures" at biology news

New U. of Colorado at Boulder flu chip may help combat future epidemics, pandemics

...Colorado at Boulder that can determine the genetic signatures of specific influenza strains from patient samples within hours may help world health officials combat coming epidemics and pandemics. Tests last month on the new technology by the Centers for Disease Control and Prevention in Atlanta showed the CU-...

UCLA discovery will aid in treatment of patients with a deadly brain cancer

...el's team also is working to uncover the molecular signatures in the tumors of non-responders so they can determine what therapies might be most effective for them. "This is a much more hopeful period now in cancer research," Mischel said. "Genomic and proteomic technologies are helping us begin to understand ...

Harnessing genomic research

...Cambridge are exploring ways to identify molecular signatures resulting from the loss of specific gene function in breast cancers that will correlate with susceptibility to a new anti-cancer drug being developed by KuDOS. The drug involved has the potential to kill tumour cells without affecting normal cells, s...

Microarray technology for tailoring breast cancer therapy

...is. From these samples they identified the genetic signatures shown by 38 patients who had a poor prognosis - defined as relapse or death from any cause within 5 years. The remaining 121 patients were defined as the 'good prognosis' group. The researchers also used gene expression profiling to separate patients...

Key brain regulatory gene shows evolution in humans

...ormation between humans and non-human primates for signatures of evolutionary selection. ...

New vaccine platform may fight infections with causes from influenza to bioterrorism

...ccine, so called because it has only the molecular signatures of these constructs: the molecule used by activated CD4+ T cells to signal production of antibodies, and importantly, the specific fragment of pneumocystis that receptors on these antibodies recognize. The researchers first identified as key CD40L,...

UT Southwestern researchers develop screening test for cells that activate immune system

...nd materials invading the body - and for molecular signatures of tissue damage or infection. "Their primary job is to present antigens to the immune system so that you develop protective immunity for infection and cancer," said Dr. Takashima. The DC biosensor system should help pharmaceutical and biotech comp...

Can our genes tell the story of our divergence?

...ournal PLoS Biology. One way to find such genetic signatures is to search for genes that reveal signs of positive natural selection. The assumption is that genes touched by positive selection will show more functionally significant molecular changes than unaffected regions. In the new study, Rasmus Nielsen, Mi...

A probe, not an echo

...rentiate types of tissue based on their multi-band signatures caused by their varying attenuation patterns. This promises to allow non-invasive detection of lesions in clinical diagnosis, which represents the "holy grail" of medical imaging. The team found it possible to identify various anatomical structures ...

Scripps scientists find potential for catastrophic shifts in Pacific ecosystems

...basic methods for testing for linear and nonlinear signatures were developed by Sugihara over years of studying a variety of complex systems (ecosystems, atmospheric systems, neurobiological systems, cardiac rhythms, market systems) and their dynamics and have been proven in small-scale ecological applications,...

Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia

...sparate response to these drugs. Specific genetic signatures related to ALL treatment failure and chemotherapeutic cross-resistance were more effective at identifying select populations of patients with inferior treatment outcomes than expression patterns associated with resistance to a single drug. "These fin...

Compounds in plastic packaging act as environmental estrogens altering breast genes

...ctive biological compounds could alter the genomic signatures of the mammary gland during critical stages of development." BPA (bisphenol A) is a synthetic resin used in food packaging, dental sealants and polycarbonate plastic products, which range from CDs and eyeglass lenses to tableware and food and beverag...

Bioelectronic ‘signatures?hold key to DNA mutations

...nocrystal tagging of DNA to create electro-diverse signatures and combining them with a fast, portable, low-cost electronic detection,?Wang says. To achieve the desired results, Wang and his researchers custom-made several individual nanocrystals, known as quantum dots, from four heavy metal salts of lead, cad...

Study reveals new technique for fingerprinting environmental samples

...(DOE JGI) demonstrates for the first time that the signatures of the genes alone in terrestrial and aquatic samples can accurately diagnose the health of the sampled environments. This study, published in the April 22nd edition of the journal Science positions large-scale genome sequencing to accelerate advance...

Gene Signatures Predict Interferon Response For Multiple Sclerosis Patients

...ution that the mechanisms connecting these genetic signatures to specific outcomes—and the mechanisms that produce a positive interferon response—have yet to be established. For now, these patterns should be thought of as markers. Still, these results suggest that doctors could one day tailor MS patients' treat...

Unexpressed But Indispensable -- The DNA Sequences That Control Development

...enes are expressed. Unlike coding sequences, whose signatures are easy to spot, the characteristic features of non-coding regulatory elements are largely unknown, making their discovery by simple sequence analysis difficult. In this issue, Greg Elgar and colleagues attack this problem by comparing the non-codin...

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